DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bace1 and cathD

DIOPT Version :9

Sequence 1:	NP_035922.4	Gene:	Bace1 / 23821	MGIID:	1346542	Length:	501	Species:	Mus musculus
Sequence 2:	NP_001334713.1	Gene:	cathD / 45268	FlyBaseID:	FBgn0029093	Length:	392	Species:	Drosophila melanogaster

Alignment Length:	409	Identity:	109/409 - (26%)
Similarity:	168/409 - (41%)	Gaps:	86/409 - (21%)

- Green bases have known domain annotations that are detailed below.

Mouse    52 EEPG-----------RRGSFVEM---VDNLRGKSGQG-------------YYVEMTVGSPPQTLN 89
            |:||           .|..|.::   :..||.:.|.|             ||..:.:|||||...
  Fly    23 EKPGLLRVPLHKFQSARRHFADVGTELQQLRIRYGGGDVPEPLSNYMDAQYYGPIAIGSPPQNFR 87

Mouse    90 ILVDTGSSNFAVGAAP-H-----PFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSI 148
            ::.||||||..|.:.. |     ..:|..|....|.||........:.|..|...|.|.||.|||
  Fly    88 VVFDTGSSNLWVPSKKCHLTNIACLMHNKYDASKSKTYTKNGTEFAIQYGSGSLSGYLSTDTVSI 152

Mouse   149 PHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHI-PNIFS 212
            . |.::..:....|::|....|: .:.::|||||.|..|:  .|.::|.|.::.:|..| ..:||
  Fly   153 A-GLDIKDQTFAEALSEPGLVFV-AAKFDGILGLGYNSIS--VDKVKPPFYAMYEQGLISAPVFS 213

Mouse   213 LQLCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMD 277
                   |.||:..| :..||.:|.||.|.:.|||...|.|:.|:.|:::.:....|.  ||::
  Fly   214 -------FYLNRDPA-SPEGGEIIFGGSDPNHYTGEFTYLPVTRKAYWQIKMDAASIG--DLQL- 267

Mouse   278 CKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFP 342
            ||  ...:.|.|:||:.:..|.:         :|.|..:|......:|.|.|. .....|.  .|
  Fly   268 CK--GGCQVIADTGTSLIAAPLE---------EATSINQKIGGTPIIGGQYVV-SCDLIPQ--LP 318

Mouse   343 VISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGT----------VMGAV 397
            ||...|.|    ::|.:.  .:.|:..|..:.       |........|.          ::|.|
  Fly   319 VIKFVLGG----KTFELE--GKDYILRVAQMG-------KTICLSGFMGLDIPPPNGPLWILGDV 370

Mouse   398 IMEGFYVVFDRARKRIGFA 416
            .:..:|..||....|:|||
  Fly   371 FIGKYYTEFDMGNDRVGFA 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bace1	NP_035922.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..58		3/16 (19%)
		beta_secretase_like	72..437	CDD:133140	102/375 (27%)
		Asp	75..416	CDD:278455	98/357 (27%)
		Interaction with RTN3. /evidence=ECO:0000250	479..501
		DXXLL. /evidence=ECO:0000250\|UniProtKB:P56817	496..500
cathD	NP_001334713.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810