DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bace1 and Bace

DIOPT Version :9

Sequence 1:	NP_035922.4	Gene:	Bace1 / 23821	MGIID:	1346542	Length:	501	Species:	Mus musculus
Sequence 2:	NP_001285756.1	Gene:	Bace / 34182	FlyBaseID:	FBgn0032049	Length:	372	Species:	Drosophila melanogaster

Alignment Length:	389	Identity:	100/389 - (25%)
Similarity:	156/389 - (40%)	Gaps:	82/389 - (21%)

- Green bases have known domain annotations that are detailed below.

Mouse    42 RLP--RETDEESEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGA- 103
            :||  |..|||               .|.......||..:::|:|.|:..:|.|:||||..|.:
  Fly    49 QLPSLRSVDEE---------------QLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSN 98

Mouse   104 ---APHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITE 165
               :.....|..|....||||....:...:.|..|...|.|.||.|.: :|.::..:....:..|
  Fly    99 TCKSDACLTHNQYDSSASSTYVANGESFSIQYGTGSLTGYLSTDTVDV-NGLSIQSQTFAESTNE 162

Mouse   166 SDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPN-IFSLQLCGAGFPLNQTEALA 229
            ....| |.:|::||||:||..:|  .|.:.|.|.::|.|..:.| :||..|...|        .:
  Fly   163 PGTNF-NDANFDGILGMAYESLA--VDGVAPPFYNMVSQGLVDNSVFSFYLARDG--------TS 216

Mouse   230 SVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTN 294
            ::||.:|.||.|.|||:|:|.|.||..:.|::..:....|:|..|..||      ::|.|:||:.
  Fly   217 TMGGELIFGGSDASLYSGALTYVPISEQGYWQFTMAGSSIDGYSLCDDC------QAIADTGTSL 275

Mouse   295 LRLP-------KKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEV 352
            :..|       .::...........||....||        |.:..|.|.:
  Fly   276 IVAPYNAYITLSEILNVGEDGYLDCSSVSSLPD--------VTFNIGGTNF-------------- 318

Mouse   353 TNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 416
                         .|:|...:..|..:|........:...::|.|.:..:|..||....|||||
  Fly   319 -------------VLKPSAYIIQSDGNCMSAFEYMGTDFWILGDVFIGQYYTEFDLGNNRIGFA 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bace1	NP_035922.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..58		6/17 (35%)
		beta_secretase_like	72..437	CDD:133140	93/357 (26%)
		Asp	75..416	CDD:278455	91/352 (26%)
		Interaction with RTN3. /evidence=ECO:0000250	479..501
		DXXLL. /evidence=ECO:0000250\|UniProtKB:P56817	496..500
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	93/377 (25%)
Bace	NP_001285756.1	Asp	68..371	CDD:278455	93/355 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841589
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740