DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ash2l and ash2

DIOPT Version :9

Sequence 1:	NP_001345941.1	Gene:	Ash2l / 23808	MGIID:	1344416	Length:	629	Species:	Mus musculus
Sequence 2:	NP_788735.1	Gene:	ash2 / 42936	FlyBaseID:	FBgn0000139	Length:	556	Species:	Drosophila melanogaster

Alignment Length:	566	Identity:	270/566 - (47%)
Similarity:	349/566 - (61%)	Gaps:	45/566 - (7%)

- Green bases have known domain annotations that are detailed below.

Mouse    78 DTLEGTGDTSEVMDTQAGSVDEE-----------NGRQLGEVELQCGICTKWF--TADTFGIDTS 129
            ||...|..:|||..|......:|           ..|.|..|||.|..|::|.  |..::.:...
  Fly     7 DTSSPTESSSEVNFTAEEDKSQETRSAAGVCYCGKERNLNIVELLCATCSRWVHETCVSYQLGKG 71

Mouse   130 SCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIP 194
            ..|||:|||.|.|..|..||...|.:.||.:.:||..|:||:. |:.::|...:..|||||:|||
  Fly    72 KLLPFITNYVFVCKNCSASGLESFRKSQATISQMCHCAIANMQ-QAASRDGRRQIQFSKDKEIIP 135

Mouse   195 FIDKYWECMTTRQRPGKMTWPNNIVKTMSKE-RDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSN 258
            :|::|||.|||..|....:|.:.:.:::.|: :.:|..:||.:.|:        .:||..|||..
  Fly   136 YIEQYWEAMTTMPRRLTQSWYSTVQRSLVKDVQTLFTYEEHAEHGA--------MYGLFHQDLRI 192

Mouse   259 IGPAYDNQKQSSAVSASGNLNGGATLGGGIAAGSSGKGRGAKRK--QQDGGTTGTTKKAR-SDPL 320
            |.|.|::..:|.|:..:.:         |....|..|....|||  ..|.|.||  ||.| |..:
  Fly   193 IKPNYESMSKSGALRLTDD---------GYTQASLSKNNRQKRKFPGTDSGPTG--KKGRPSSDI 246

Mouse   321 FSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKL-ELDCWAGKPIPGDLYRACLYERVLL 384
            .:..:|||||||||||||||||||||||||||||..::. |...||||||||.|||..:...|||
  Fly   247 TANVKLPPHGYPLEHPFNKDGYRYILAEPDPHAPFRQEFDESSDWAGKPIPGWLYRILVPHSVLL 311

Mouse   385 ALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQ 449
            ||||||||||||:|||.|.||:||.||||:|.|.:|.||||:|::|||...|.||||.:..||||
  Fly   312 ALHDRAPQLKISEDRLAVTGERGYCMVRATHSVNRGCWYFEVTIEEMPDGAATRLGWGREYGNLQ 376

Mouse   450 APLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIK 514
            ||||||||.|||||:|||||.:|.|||||..|.:||.|||.|.|||:. :...||:|:||:.|:|
  Fly   377 APLGYDKFGYSWRSRKGTKFTESHGKHYSDAYVEGDTLGFLIELPEEA-SLDYLPNTFKDRPLVK 440

Mouse   515 FKSYLYFEEKDFVDKAEKSLKQTPHSEIIFYKNGVNQGVAYRDIFEGVYFPAISLYKSCTVSINF 579
            |||:||:|:||.:.:..|:|.....|.|.|:|||.:||||:.||:.|.||||||::||.|||:||
  Fly   441 FKSHLYYEDKDKITETLKNLHILQGSRIEFFKNGQSQGVAFEDIYAGSYFPAISIHKSATVSVNF 505

Mouse   580 GPSFKYPPKDLTYHP---MSDMGWGAVVEHTLADVLYHVETEVDGR 622
            ||:||| |:.|..|.   |.|.....:.|..|||.||  .||.|||
  Fly   506 GPAFKY-PEVLVEHKAKGMHDRVEELITEQCLADTLY--LTEHDGR 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ash2l	NP_001345941.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..99		7/20 (35%)
		DNA-binding. /evidence=ECO:0000250	63..172		36/106 (34%)
		PHD_ash2p_like	96..145	CDD:277058	18/61 (30%)
		Interaction with RBBP5. /evidence=ECO:0000250\|UniProtKB:Q9UBL3	317..629		187/310 (60%)
		SPRY_Ash2	393..584	CDD:293932	115/190 (61%)
ash2	NP_788735.1	PHD_ash2p_like	36..87	CDD:277058	17/50 (34%)
ash2	NP_788735.1	SPRY_Ash2	320..510	CDD:293932	115/190 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831913
Domainoid	1	1.000	262	1.000	Domainoid score	I1940
eggNOG	1	0.900	-	-		E1_KOG2626
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3436
Inparanoid	1	1.050	484	1.000	Inparanoid score	I1430
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S981
OMA	1	1.010	-	-		QHG53232
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004969
OrthoInspector	1	1.000	-	-		oto91990
orthoMCL	1	0.900	-	-		OOG6_102272
Panther	1	1.100	-	-	LDO	PTHR10598
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R95
SonicParanoid	1	1.000	-	-		X4622
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740