DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arih2 and ari-1

DIOPT Version :9

Sequence 1:	NP_001344212.1	Gene:	Arih2 / 23807	MGIID:	1344361	Length:	492	Species:	Mus musculus
Sequence 2:	NP_001245736.1	Gene:	ari-1 / 32796	FlyBaseID:	FBgn0017418	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	495	Identity:	163/495 - (32%)
Similarity:	270/495 - (54%)	Gaps:	23/495 - (4%)

- Green bases have known domain annotations that are detailed below.

Mouse    13 NEEDYDPNCEEEEEEEEDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALHEHMT 77
            |:.|:..|.:.......|.|| :|:  |:..|:........|.::||:..||..|......|.:.
  Fly     5 NDNDFCDNVDSGNVSSGDDGD-DDF--GMEVDLPSSADRQMDQDDYQYKVLTTDEIVQHQREIID 66

Mouse    78 SLASVLKVSHSVAKLILVNFHWQVSEILDRYRSNSAQLLVEARVQPNP------SKHVPTAHPPH 136
            ....:||:.....:::|.:|.|...::|::|..::.....:.....||      .|...:.....
  Fly    67 EANLLLKLPTPTTRILLNHFKWDKEKLLEKYFDDNTDEFFKCAHVINPFNATEAIKQKTSRSQCE 131

Mouse   137 HCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSV-LVKDGVGVGISCMAQDCPLRTPEDFVFPLL 200
            .|.:|...:..:::..|.|.|:||..||.::.|. :|.:|:|..|||.|..|.:...:..|..|:
  Fly   132 ECEICFSQLPPDSMAGLECGHRFCMPCWHEYLSTKIVAEGLGQTISCAAHGCDILVDDVTVANLV 196

Mouse   201 PNEELRDKYRRYLFRDYVESHFQLQLCPGADCPMVIRVQEPRARRVQCNRCSEVFCFKCRQMYHA 265
            .:..:|.||::.:...:||.:..|:.||..||...::|.....|||.| :|..||||.|.:.:|.
  Fly   197 TDARVRVKYQQLITNSFVECNQLLRWCPSVDCTYAVKVPYAEPRRVHC-KCGHVFCFACGENWHD 260

Mouse   266 PTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQC--SKCKHDFCWMCLGD 328
            |..|..::||:.||.|||||:|:|:|:||:||:|::.|||:||||||.|  ..||::|||:|||.
  Fly   261 PVKCRWLKKWIKKCDDDSETSNWIAANTKECPRCSVTIEKDGGCNHMVCKNQNCKNEFCWVCLGS 325

Mouse   329 WKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYERIHEKIQ 393
            |:.|||.:|.|:||.|:.....:..|.:.|.:|.:||.|:.|:.||.:|::.|.:.|..:.:|::
  Fly   326 WEPHGSSWYNCNRYDEDEAKTARDAQEKLRSSLARYLHYYNRYMNHMQSMKFENKLYASVKQKME 390

Mouse   394 ERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSW 458
            |...:|: :||:.|:|:.|..:|.:||.||.|||.:|||::...:..:||..|..||:..|.||.
  Fly   391 EMQQHNM-SWIEVQFLKKAVDILCQCRQTLMYTYVFAYYLKKNNQSMIFEDNQKDLESATEMLSE 454

Mouse   459 KVER-------ADSYDRGDLENQMHIAEQRRRTLLKDFHD 491
            .:||       ||...:  ::::....|:|...|||..|:
  Fly   455 YLERDITSENLADIKQK--VQDKYRYCEKRCSVLLKHVHE 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arih2	NP_001344212.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		6/23 (26%)
		UBA-like. /evidence=ECO:0000250\|UniProtKB:Q9Y4X5	64..111		10/46 (22%)
		TRIAD supradomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01221	134..343		86/211 (41%)
		RING-HC_RBR_TRIAD1	136..189	CDD:319687	18/53 (34%)
		RING-HC finger (C3HC4-type)	138..187	CDD:319687	17/49 (35%)
		IBR	207..269	CDD:214763	22/61 (36%)
		IBR	<297..329	CDD:366672	20/33 (61%)
		Ariadne domain. /evidence=ECO:0000250\|UniProtKB:Q9Y4X5	358..492		48/141 (34%)
ari-1	NP_001245736.1	IBR	204..264	CDD:214763	22/60 (37%)
ari-1	NP_001245736.1	IBR	<286..326	CDD:279784	24/39 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54219
OrthoDB	1	1.010	-	-		D429758at33208
OrthoFinder	1	1.000	-	-		FOG0000379
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X447
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930