DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Apc2 and Apc

DIOPT Version :9

Sequence 1:NP_001359169.1 Gene:Apc2 / 23805 MGIID:1346052 Length:2317 Species:Mus musculus
Sequence 2:NP_001263046.1 Gene:Apc / 44642 FlyBaseID:FBgn0015589 Length:2417 Species:Drosophila melanogaster


Alignment Length:2555 Identity:662/2555 - (25%)
Similarity:954/2555 - (37%) Gaps:783/2555 - (30%)


- Green bases have known domain annotations that are detailed below.


Mouse   228 AQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLEAQDRVQQTEPQALLAVKPVAVEEEQEA 292
            ||.:|.:.|.|  :.|...:|...:..:|:::               |.......|.:......:
  Fly   127 AQELREMREHR--SLDRNFERQSAQQQQLDEL---------------PPRNGGGSPASAGRPSRS 174

Mouse   293 EVPTHP-----EDGTPQPG--------------------------NSKVEVVFWLLSMLATRDQE 326
            :.|::.     :...|.|.                          .||||.|:.|||||.:.|..
  Fly   175 KEPSYTLSRFLDGDAPAPAPRLPKGAAWTTSFDERYTSSAVEATLGSKVECVYSLLSMLGSNDPL 239

Mouse   327 DTARTLLAMSSSPESCVAMRRSGCLPLLLQILHGTEAGSVGRAGIPGAPGAKDARMRANAALHNI 391
            :.|:..|.:|.:.:||..:|||||:|||:|::|..:             ..::.|..|..||||:
  Fly   240 EMAKKFLELSGNAQSCATLRRSGCMPLLVQMMHAPD-------------NDQEVRKCAGQALHNV 291

Mouse   392 VFSQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDSGTESGTGDTPVPIEPQICQATCAVMK 456
            |.|.||:...|:|.:||.:|:||..||......||   ||.|:...|:    :.....|..::||
  Fly   292 VHSHPDEKAGRREAKVLRLLDQIVDYCSFLKTLLQ---SGGEAIADDS----DRHPLAAISSLMK 349

Mouse   457 LSFDEEYRRAMNELGGLQAVAELLQVDYEMH-KMTRDPLNLALRRYAGMTLTNLTFGDVANKATL 520
            :|||||:|.||.|||.|.|:..|:.:|:.:| ....|....:|||||.|.||||||||..|||.|
  Fly   350 VSFDEEHRHAMCELGALHAIPNLVHLDHAVHGPKPEDQCCNSLRRYALMALTNLTFGDENNKALL 414

Mouse   521 CARRGCMEAIVAQLGSESEELHQVVSSILRNLSWRADINSKKVLREVGSMTALMECVLRASKEST 585
            |.::..|||:||||.|..::|.||.:|:|||||||||.|.|.||.|:|::|||....:|...|:|
  Fly   415 CGQKQFMEALVAQLDSAPDDLLQVTASVLRNLSWRADSNMKAVLNEIGTVTALALAAMRNRSENT 479

Mouse   586 LKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYRCQGNSLAVIESGGGILRNVSSLIATR 650
            ||::||||||||||.:.|||..|.|||||.|||..|:|.....:|.:||:.|||||||||.||..
  Fly   480 LKAILSALWNLSAHCSTNKAEFCAVDGALAFLVGMLSYEGPSKTLKIIENAGGILRNVSSHIAVC 544

Mouse   651 EDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSPRDQELLWDLGAVGMLRNLVHSK 715
            |.|||:||.||||..|||.|.|.|||:|||:|||||||||||..||:.|||.|||.|||:|:|||
  Fly   545 EPYRQILRQHNCLAILLQQLKSESLTVVSNSCGTLWNLSARSAEDQKFLWDNGAVPMLRSLIHSK 609

Mouse   716 HKMIAMGSAAALRNLLAHRPA---KYQAAAMAVSPG-TCVPSLYVRKQRALEAELDTRHLVHALG 776
            |.||:.||::||:|||..|||   .:|...:|.|.| ..:|:|..||.:||:.||..||......
  Fly   610 HAMISEGSSSALKNLLNFRPAVQNHHQLDPIARSMGLKALPTLEARKAKALQQELGERHTAETCD 674

Mouse   777 HLE---KQSLPEAETTSKK-PLPPLRHLDGLVQD------YASDSGCFDDDDAPSLAAAATTAEP 831
            :|:   |.....|.::|:: |.|.|.....|.:.      |::.|.|..|....| |:|:.....
  Fly   675 NLDTGGKLDKERASSSSRRHPAPRLTRSAMLTKSESRDSVYSAKSDCAYDHLIRS-ASASDAHRK 738

Mouse   832 ASPAVMSMFLGGPFLQGQALARTPPARQGGLEAEKEAGGEAAVAAKAKAKLALAVARIDRLVEDI 896
            ..|.:....|                   .:|.:.||..|..:....|..        :...:..
  Fly   739 VKPKITDFDL-------------------EMEQDTEATEEQPIDYSVKYS--------ENATKTS 776

Mouse   897 SALHTSSDD--SFSLSSGDPGQEAPREGRAQSCSPCRGTEGGRR-----------EAGSRAHPLL 948
            :...|..|.  .|||...        |.:.:|.....|..||::           |.......||
  Fly   777 TYQETDLDQPTDFSLRYA--------ENQIESDLDISGPAGGQKSTITPPAETVPEKSEGQEILL 833

Mouse   949 RLKAAHTSLSNDSLNSGSTSDGYCTREHMTPCPLAALAEHRDDPVRGQTRPSRLDLDLPSRAELP 1013
            .|        :||:....|.|        ||..::..|             |..||.:.::|:  
  Fly   834 IL--------DDSVKCYQTED--------TPYVISNAA-------------SVTDLRVAAKAD-- 867

Mouse  1014 ARDTAATDARVRTIKLSPTYQHVPLLDGAAGAGVRPLVGPGTS-PGARKQAWIP----ADSLSKV 1073
                                         |.|.|:|.|...|| .||.|:  :|    ..|.|..
  Fly   868 -----------------------------AEAEVKPEVREVTSKEGAPKK--LPKLSQCGSGSYT 901

Mouse  1074 PEKLVASPLPIASKVLQKLVAQDG-PMSLSRCSSLSSLSSTGHAVPSQA---ENLDSDSSLEGLE 1134
            |||      ||.       ..::| |...||..|||||..:|.|  :||   .:.|....||..|
  Fly   902 PEK------PIN-------YCEEGTPGYFSRYDSLSSLDESGKA--NQAIVGTDADIKPKLEKQE 951

Mouse  1135 --EAGPGEAELGRAWRASGSTSLPVSIPAPQRGRSRGLGVEDATPSSSSENCVQETPLVLSRCSS 1197
              |:.|.|..|                                |...:..|...||||:.||.||
  Fly   952 EQESQPAEQVL--------------------------------TKPPTQANSALETPLMFSRRSS 984

Mouse  1198 VSSLGSFESRSIA-----SSIPSDPCSGLGSGTVSPSELPDSPGQTMPPSRSKTPPAPPGQ---- 1253
            :.||.......:|     ||:.|| .|.|.||.:||||:||||.|:||.|..:...|..||    
  Fly   985 MDSLVHDPDVDVANCDDKSSVVSD-FSRLASGVISPSEIPDSPTQSMPQSPRRNSVAGSGQNVDS 1048

Mouse  1254 -PETSQFSLQWESYVKRFLDIADCRERCQPPSELDAGSVRFTVEKPDENFSCASSLSALALHE-- 1315
             |.....|||                ..:...|.|..|  |.||.....||.|:|||.|::.:  
  Fly  1049 PPVVIPASLQ----------------PLRSVFEDDLSS--FNVEHTPAQFSTATSLSNLSIVDDE 1095

Mouse  1316 ----LYVQQDVELRLRPPACPERAVGGGGHRRRDEAASRL-------------------DGPA-- 1355
                ...::|.|..|....|    :..|..|:..||....                   |.||  
  Fly  1096 KAPASVAEEDNEDELLLANC----INMGMQRKPTEAVKSTVVNSEVDVAEETIRSYCTEDTPALL 1156

Mouse  1356 ---PAGSR----ARSATD-KELEA----------------------------LRECLGAAMPARL 1384
               |:.:.    :.|:|| |:..|                            |::|:...|...|
  Fly  1157 SKVPSNTNLSVISMSSTDPKDATAGQAQMYAHQLSDDVSSNASDCGGASGHLLQQCIRDGMKKPL 1221

Mouse  1385 RKVAS----ALVPGRRSLP--VPVYMLVPAPARGDDSGTDSAEGTPVNFSSAASLSDET----LQ 1439
            .:..|    .|..|...||  :|         ..|:......|.:|.|||..:.||:.|    |.
  Fly  1222 GEATSDPIAMLRRGGNELPGYLP---------SADEMNKFLVEDSPCNFSVVSGLSNLTVGSSLV 1277

Mouse  1440 GPS---RDKPAGPGDRQKPTGRAAPARQTRSHRPK-------------------------AAGAG 1476
            ||:   ::......| |.|..:|.|.:|.:..||.                         |||..
  Fly  1278 GPAVQLKETEPSSAD-QNPEMKAKPGKQEQVRRPPHWQDDSLSSLSIDSEDDTNLLSQAIAAGCN 1341

Mouse  1477 KSTEHTRGPCRNRAGLELPLSRP-----------------------QSARSNRDSSCQTRTRGDG 1518
            :...:.......:....|..|:|                       |.:.|:.||| .:......
  Fly  1342 RPKSNLGFSSNGKRSSSLSSSQPIAINAATSASSLNSAMTVRKSQQQESYSSVDSS-DSNDNQSK 1405

Mouse  1519 ALQSLCLTTPTEEAVYCFYDSDEEPPATA-----------------PPPRRASAIPRAL------ 1560
            :|..||:.    :.:|    ..:||.|.|                 |..::..::|..|      
  Fly  1406 SLFELCIL----KGMY----KTKEPGARAQQMQEQPIVGSSSVQSNPSLKQFDSLPVQLPSSGQV 1462

Mouse  1561 -----------KREKPAGRKETPSRAAQPA-----TLPVRAQPRLIVDET----PPCYSL--TSS 1603
                       .||:...||:  .:..|..     :..:.|.|:.::..:    .||:.:  |:|
  Fly  1463 KRQRHHHHHHHHRERERERKD--EKLLQECINTGISKKINAVPKNVLATSAAALEPCHPMAATTS 1525

Mouse  1604 ASSLSEPEAP--EQPANHARGPEQGSKQDSS----PSP-RAEEELLQRCISLAMPRRRT------ 1655
            ||:|| ..||  ||.|:....|:|.|....|    |:| .|...:.....|.|.|.:..      
  Fly  1526 ASALS-TAAPDVEQKAHATSNPQQQSSTHPSSHILPNPIDAIATVTDTVRSPAAPNQGNGNASQN 1589

Mouse  1656 ---QVPGSR------RRKPRALRSDIRPT------EITQKCQEEVAGS-----DPASDLDSVEWQ 1700
               ...||:      |....:.:|.|..|      .:.:.|   ::|:     ||...|.|||..
  Fly  1590 GLETATGSKDLDSEDRSSDESNQSFIMETMVRLDSALNETC---ISGASEKHKDPDLMLKSVERL 1651

Mouse  1701 AIQ---------------------EGANSIVTW-------------LHQAA---AKASL-EASSE 1727
            .::                     :..:|..||             :.|.|   |..|| |.::|
  Fly  1652 TMEFVTSAEQLRSSSHNHSSSNSHKNNSSNNTWNESTCPNDVSFPSVSQTAPVLASLSLDEDATE 1716

Mouse  1728 SDSLLSLVSGVSAGSTLQPSKLRKGRKPAAEAGGAWRPEKRGTTSTKINGSPRLPNGPEKAKGTQ 1792
            :.||..|:. ::..:..||..|                  .|.|.|.:||.....:|  .:.|..
  Fly  1717 ARSLHELIE-ITPTNEQQPESL------------------EGETDTLVNGHADSYSG--SSGGLN 1760

Mouse  1793 KMMAGE----STMLRGRTVIYSAGPAS------------RTQSKGISGPCTTPKKT--------- 1832
            ..:.|:    ...|..:.::::...||            |..::.:..|..|...|         
  Fly  1761 FQLGGQVQNAGVRLEPQRLLFNGTSASIMTNSTMIAFEARALAENLLQPAATDDDTTEMTFSLNS 1825

Mouse  1833 -------GTSGT----------TQPETVTKA-PSPEQQRSRSLHRPGKISELAALRHPPRSA--- 1876
                   ..||.          :||.::.:| ||...:.:|.:. |..:....||.|...||   
  Fly  1826 LDLDNIRPPSGMESLNSCYQDHSQPSSLRQAMPSKSPRFARKMF-PANLVARRALGHLAGSAESV 1889

Mouse  1877 ----------TPPA--------------------------RLAKTPSSSSSQTSPASQPL----- 1900
                      .||:                          .:|.|.|.|:.:|:......     
  Fly  1890 NSSCNLLDNIKPPSLMDELLDSMISVDSIQSEVADGEQDCSMATTISVSNYETAACDDQTMTVLQ 1954

Mouse  1901 ------------PRRSPLATPTGGPLPGPG-GSLVPKSPARALLAKQHKT--------QKSPVRI 1944
                        ...|..:||..|..|.|. .||.||. .|.|...:.||        .::|...
  Fly  1955 SCFDEDEDATMNDYSSAESTPKHGSTPSPNRRSLTPKD-KRRLTKDRFKTYTIATSCEMEAPEAN 2018

Mouse  1945 PFMQRPARRVPPPLARPSPEPGSRGRAGAE-------GTPGARGSRLGLVRMASARSSGSESSDR 2002
            ..:|........|:|.|||....|.|..||       ..|      |.|::.........:.|..
  Fly  2019 ETLQIEIVEAAVPVATPSPRANGRRRGSAERYKTQLIECP------LALIQPQPDDCPSEQLSSI 2077

Mouse  2003 SGFRRQLTFIKESPGLLRRRRSELSSADSTASTSQAASPRRGRPALPAVFLCSSRCDELRVSPRQ 2067
            ....:|.|||.:    :....|: .:.:||.....|..              |..||:  .|..:
  Fly  2078 RAMMQQFTFITD----INIGHSQ-ETCESTDHPEDAGE--------------SPECDQ--NSETE 2121

Mouse  2068 PLAAQRSPQAKPGLAPRAPRRTSSESPSRLPVRASPGRPETVKRYASLPHISVSRRSDSAVSVPT 2132
            ....|...|..|             .||.:.:|.|..:|.|::. |:...:...|:..:.||..:
  Fly  2122 SCDGQEPDQLPP-------------PPSIVDLRTSVVKPTTLEP-ATAVKLVRGRKKPAYVSPYS 2172

Mouse  2133 TQANATRRGSDGEARPLPRVAPPGTTWRRIKDEDVPHILRSTLPATALPLRVSSPEDSPAGTPQR 2197
            .|   ::|.|:..|....:...|....|.:    ||......|||...|  ...||.:||...::
  Fly  2173 MQ---SQRNSNNAAPSKKKTLSPTIAKRSL----VPGGSGVRLPAKKKP--TPPPEPAPARLERQ 2228

Mouse  2198 KT-----------SDAVVQTEDVATSKTN------------SSTSPSLESRDP---PQAPASGPV 2236
            .|           ...||:|:...||.|:            |..||| ::..|   |.|||. .:
  Fly  2229 GTFVKDEPTNSNVQVPVVETKPAQTSPTHRASKLPTKKGTASGGSPS-KAGSPKRIPLAPAR-RM 2291

Mouse  2237 APQGSDVDGPVLTKPPASAPFPHEGLSAVIAG-----FPTSR-----HGSPSRAARVPPFNYVPS 2291
            .||.::      |....:|...| ..|.|::|     .|.||     :||.:.||.....|:..|
  Fly  2292 TPQRAN------TSLRLAAGKSH-AASRVVSGRVSSTTPPSRSNSNLNGSSAAAAAAAKINHAQS 2349

Mouse  2292 PMAAATMASDSAVEKAPVSS 2311
            .:|......|.|..|...|:
  Fly  2350 RIANIWKRVDEAKTKQSSSN 2369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Apc2NP_001359169.1 APC_N_CC 43..94 CDD:374728
Suppressor_APC 161..242 CDD:371516 5/13 (38%)
APC_rep 394..467 CDD:376216 27/72 (38%)
armadillo repeat 466..509 CDD:293788 19/43 (44%)
armadillo repeat 517..554 CDD:293788 20/36 (56%)
armadillo repeat 563..596 CDD:293788 17/32 (53%)
armadillo repeat 604..645 CDD:293788 23/40 (58%)
ARM 650..690 CDD:214547 28/39 (72%)
armadillo repeat 654..688 CDD:293788 24/33 (73%)
armadillo repeat 696..732 CDD:293788 23/35 (66%)
Arm_APC_u3 733..979 CDD:374686 57/272 (21%)
APC_r 1178..1201 CDD:368672 9/22 (41%)
APC_r 1290..1311 CDD:368672 10/20 (50%)
PHA03247 <1328..1665 CDD:223021 99/521 (19%)
APC_r 1413..1435 CDD:368672 7/21 (33%)
PHA03247 <1548..1987 CDD:223021 126/652 (19%)
APC_basic 1800..2125 CDD:368684 80/435 (18%)
PTZ00449 <2042..2239 CDD:185628 49/222 (22%)
ApcNP_001263046.1 ARM 222..316 CDD:237987 42/106 (40%)
armadillo repeat 258..332 CDD:293788 34/89 (38%)
ARM 332..448 CDD:237987 56/119 (47%)
armadillo repeat 369..403 CDD:293788 12/33 (36%)
armadillo repeat 411..448 CDD:293788 20/36 (56%)
armadillo repeat 498..539 CDD:293788 23/40 (58%)
ARM 506..624 CDD:237987 76/117 (65%)
armadillo repeat 548..582 CDD:293788 24/33 (73%)
armadillo repeat 590..624 CDD:293788 21/33 (64%)
APC_crr 837..860 CDD:283553 8/43 (19%)
APC_crr 903..927 CDD:283553 12/36 (33%)
APC_crr 1066..1090 CDD:283553 11/25 (44%)
APC_crr 1247..1271 CDD:283553 8/23 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837314
Domainoid 1 1.000 190 1.000 Domainoid score I3266
eggNOG 1 0.900 - - E1_KOG2122
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 548 1.000 Inparanoid score I1140
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002986
OrthoInspector 1 1.000 - - mtm8887
orthoMCL 1 0.900 - - OOG6_105450
Panther 1 1.100 - - LDO PTHR12607
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2812
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.750

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