Protein Alignment Amfr and HRD1

DIOPT Version :9

• Sequence 1: NP_035917.2
• Gene: Amfr / 23802
• MGIID: 1345634
• Length: 639
• Species: Mus musculus
• Sequence 2: NP_014630.1
• Gene: HRD1 / 854149
• SGDID: S000005373
• Length: 551
• Species: Saccharomyces cerevisiae
• Alignment Length: 556
• Identity: 111/556 - (19%)
• Similarity: 196/556 - (35%)
• Gaps: 209/556 - (37%)

Mouse    78 LFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKDK----FWNFIFYKFIFIFGVLNVQTV 138
            |.:::|:|:.     |:.:|:..::||.||:.|.:|:.::    ..|.:|...:|
Yeast    51 LSIFILLNST-----LLWQLLTKLLFGELRLIEHEHIFERLPFTIINTLFMSSLF---------- 100

Mouse   139 EEVVMWCLWFAGLVFLHLMV--QLCKDRFEYL--SFSPTTPMSS--HGRVLSLLIAMLLSCCGLA 197
            .|...:.:.|.||:.|:|.|  .:.|||.|.|  |.:.:|.|.:  ..|....|:.:.:....:.
Yeast   101 HERYFFTVAFFGLLLLYLKVFHWILKDRLEALLQSINDSTTMKTLIFSRFSFNLVLLAVVDYQII 165

Mouse   198 VVCCVTGYTH--------GMHTLAFMAAESLLVTVRTAHVILRYVIHLWDL-----------NH- 242
            ..|..:.||:        .::.:..|....||:.:  .::.|:..::.|:.           ||
Yeast   166 TRCISSIYTNQKSDIESTSLYLIQVMEFTMLLIDL--LNLFLQTCLNFWEFYRSQQSLSNENNHI 228

Mouse   243 -------EGTWEG-----------------------KGTYVY------YTDFVMELALLSLDLMH 271
                   |.|.|.                       :|.::|      :|.|:.....||:.:..
Yeast   229 VHGDPTDENTVESDQSQPVLNDDDDDDDDDRQFTGLEGKFMYEKAIDVFTRFLKTALHLSMLIPF 293

Mouse   272 HIHMLLFGN-IWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEEL--AVN 333
            .:.|:|..: :|   ..|.::.....|:     :|.|:...|      :......|.|:|  :.|
Yeast   294 RMPMMLLKDVVW---DILALYQSGTSLW-----KIWRNNKQL------DDTLVTVTVEQLQNSAN 344

Mouse   334 NDD-CAICWDSM-------------QAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNIADGS 384
            :|: |.||.|.:             :..::|||||:.|.|||::|:|:..:||.||:
Yeast   345 DDNICIICMDELIHSPNQQTWKNKNKKPKRLPCGHILHLSCLKNWMERSQTCPICRL-------- 401

Mouse   385 RAREDHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGITQAS 449
                            ||...:|                                 |::..|..|
Yeast   402 ----------------PVFDEKG---------------------------------NVVQTTFTS 417

Mouse   450 NSQLNAMAHQIQEMFPQVPYHLVLQDLQMTRSVEITTD--------NILEGRIQVP----FPTQR 502
            ||.:....                   .:|.|..|.||        ::|..|...|    .|||.
Yeast   418 NSDITTQT-------------------TVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQN 463

Mouse   503 SDSLRPALNSPVERPSPDL------EEGEASVQTER 532
            .|:|.....| ...|||..      :.|:.||.:.|
Yeast   464 IDTLAMRTRS-TSTPSPTWYTFPLHKTGDNSVGSSR 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Amfr	NP_035917.2	HRD1	82..>378	CDD:227568	81/378 (21%)
		zf-RING_2	335..375	CDD:290367	18/53 (34%)
		CUE_AMFR	454..494	CDD:270604	6/47 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..531		11/36 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	594..620
		VCP/p97-interacting motif (VIM). /evidence=ECO:0000250|UniProtKB:Q9UKV5	618..636
HRD1	NP_014630.1	HRD1	5..551	CDD:227568	111/556 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810