DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Amfr and sip3

DIOPT Version :9

Sequence 1:	NP_035917.2	Gene:	Amfr / 23802	MGIID:	1345634	Length:	639	Species:	Mus musculus
Sequence 2:	NP_001263152.1	Gene:	sip3 / 43747	FlyBaseID:	FBgn0039875	Length:	626	Species:	Drosophila melanogaster

Alignment Length:	674	Identity:	150/674 - (22%)
Similarity:	262/674 - (38%)	Gaps:	188/674 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse    72 YLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFW--------NFIFY---- 124
            |:...:..:.|:......::.:..||:..|..|.||.:|.:||.::||        .|..:
  Fly    33 YITKSNASMGVIYIQFFVIVFMFGKLLSKIFLGTLRAAEFEHLLERFWYALTETCLAFTVFRDDF 97

Mouse   125 --KFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGRVLSLLI 187
              :|:.:|.|                  |:||.....|.::|.:::..||......|.||.|||.
  Fly    98 NPRFVALFTV------------------LLFLKSFHWLAEERVDFMERSPVLGWLFHIRVGSLLT 144

Mouse   188 AMLLSCCGLAVVCCVTGYTHGM-----HTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWE 247
            .:.:    |..|..:..|...:     ..|.|....::|:|| .|...::||:|..::..:..||
  Fly   145 VLGI----LDYVLLIHAYNSTLVRGPTVQLVFGFEYAILLTV-IASTAIKYVLHAAEMRTDTPWE 204

Mouse   248 GKGTYVYYTDFVMELALLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYL 312
            .|..::.||:.|:.|..:.|       .:||..|...:.:|.:|: .|.:|..: |..|:..|.:
  Fly   205 NKAVFLLYTELVIGLIKVVL-------YILFVVIMAKIYALPMFV-FRPMFFTI-RNFRKALNDV 260

Mouse   313 ----RVVGNMEARFAVATPEELAVNNDDCAICWDSM-QAARKLPCGHLFHNSCLRSWLEQDTSCP 372
                |.:.||...:..||||||..:::.|.||.:.| ..::||||||:||.:|||||.::..:||
  Fly   261 IMSRRAIRNMNTLYPDATPEELRQSDNICIICREDMVNHSKKLPCGHIFHTTCLRSWFQRQQTCP 325

Mouse   373 TCRMSL---------------------------------------------NIADGSRAREDHQG 392
            |||:::                                             .:.||::||.|
  Fly   326 TCRLNILRTPTVNSTAMPRQGDEAVAAAAGNPIPAAAGVQPAGGVPPPAPTAVVDGNQARAD--- 387

Mouse   393 ENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFS--------VEVMHTTNIL------ 443
                   |.||..:..|. |..:.|  .|.|.:.:.||:.:        |..|.:..::
  Fly   388 -------VNVAGGQALPP-NFADLF--GDASGLPNGLPNLAGLQIPPPPVMPMISPFMIPPHFGY 442

Mouse   444 -----------GITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQMTRSVEITTDNI-------- 489
                       .:|..::.:|.||....::       |:| |.|::.:::.:..|:.
  Fly   443 LTPLPPPPIPQDLTNFTDEELRAMEGLQRD-------HIV-QRLKLLQNINLMLDSAGIMMSQYQ 499

Mouse   490 -LEGRIQVPFPTQRSDSLRPALNSPVERPSPDLEEGEASVQTERVPLDLSPRLEETLDFSEVELE 553
             |..|:|:...|..:     |:|...:....|:....|:...:.....::|....:.....:..|
  Fly   500 SLSARLQLTAVTPAT-----AVNGSADSSVYDMPSTSATAMAQLETHQVTPTAAASSASPTMPAE 559

Mouse   554 PIEVEDFEARGSRFSKSADERQRMLVQRKDDLLQQARKRFLNKSSEDDGASERLLPSEGTSSDPV 618
            .:.:||..|       .|||         ||:...|.:.....:|:.|        .|..||:..
  Fly   560 KVTIEDLGA-------DADE---------DDIPSTATEAVSIPNSDAD--------FEENSSELG 600

Mouse   619 TLRRRMLAAAAERR---LQRQRTT 639
            .||:|.|....||.   ...:|||
  Fly   601 ELRKRRLKFLEERNKSAATNERTT 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amfr	NP_035917.2	HRD1	82..>378	CDD:227568	90/319 (28%)
		zf-RING_2	335..375	CDD:290367	20/40 (50%)
		CUE_AMFR	454..494	CDD:270604	8/48 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..531		5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	594..620		5/25 (20%)
		VCP/p97-interacting motif (VIM). /evidence=ECO:0000250\|UniProtKB:Q9UKV5	618..636		6/20 (30%)
sip3	NP_001263152.1	HRD1	20..>365	CDD:227568	91/363 (25%)
sip3	NP_001263152.1	zf-RING_2	287..328	CDD:290367	20/40 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810