Protein Alignment ALK and alk

DIOPT Version :10

• Sequence 1: NP_004295.2
• Gene: ALK / 238
• HGNCID: 427
• Length: 1620
• Species: Homo sapiens
• Sequence 2: NP_001410894.1
• Gene: alk / 563509
• ZFINID: ZDB-GENE-031027-1
• Length: 1705
• Species: Danio rerio
• Alignment Length: 1674
• Identity: 784/1674 - (46%)
• Similarity: 1021/1674 - (60%)
• Gaps: 188/1674 - (11%)

Human    45 SYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKA--GRPEARGSLALDCAPLLRLLG---- 103
            |.||::||:|:|||.||||.|.|....:..|.:.:..:  |....|.:|.:.|.||.:.:.
Zfish    51 STSRIKRKTLSVDFAVPSLLRYYLALFIKRPLNGDCLSFNGCYTVRANLLMRCVPLQKTIAGLLD 115

Human   104 ---PAPGVSWTAGSPAP-AEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVG--PPGEAA 162
               .|..|:.::....| .:.|.:.:||..|.....|::.|:|:|:|||.:..||.|  ...:|.
Zfish   116 AKLAAMNVNRSSTGQLPYRQKRPVPKVLNLGLTSASRKSNQVVVEVGEEMVKTGCGGLHVYEDAP 180

Human   163 VGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSL 227
            |..|:.:|:.:..||:....||||:|||||:|....|:|.:.|||||||..||..||     :|.
Zfish   181 VVFLEMDLTRILEWWLGAEGGRLRVRLMPERKVQVPGKEDKYSAAIRASDARLFIQI-----ASS 240

Human   228 ESPTNM----PSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELE---YSPPLHDLRN 285
            |.|::.    |:.:|.|  ||.:||.:|...|...........|....|:..   |.|
Zfish   241 ERPSSTISRNPTVAPKY--WNFSWIAEDELTFPEDPVSTSDCTSKAKSCDRRPDGYYP------- 296

Human   286 QSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVS 350
             .::|....:|::..:|.........|:....|.||.:|:||.:...:||||.|::...|.|.::
Zfish   297 -EFAWSLTSAEDSWAIDQTMVKTKASSQGWEEGRFLTVNSSALTGPWVLSPWFRAAHRPCGLDIT 360

Human   351 VHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLS 415
            |..|.:.||||...|:..::....:|....|...||.|:...:.....|||::..|...|....:
Zfish   361 VFLHPRQSGRYTVWLIERDKPPLALLTTEHPHVIGWAVVHLSLAARSKPFRISSSYSQPGEIETA 425

Human   416 AVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYC 480
            ..|.....||:  |.....:.|:..:.|..|..:.:.|.|||..||.||:||.:.||:...|.||
Zfish   426 TYDPRYSTNCT--TRSSQNVTLRGRYHCRGGREINVSQLCDFSIDCPQGDDEGEHCRQFLNGSYC 488

Human   481 NFEDGFCGW--TQGTLSPHTPQWQVR-TLKDARFQDHQDHALLLSTTDVPASE--SATVTSATFP 540
            :|....|||  .||    ..|||:.. ::..:..........||:....|..:  ||.|.|..|.
Zfish   489 SFGREDCGWQPVQG----RGPQWRAHPSIPQSLRSSCPSPGALLAIDSQPKGQRGSAQVRSPLFF 549

Human   541 APIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSL-WQWMVLPLLDVS 604
            .|::::||.::. | :.|...|.:||.:.||.||.|..|.:|:..:...:.. |:.:.|||..:.
Zfish   550 YPLRNAPCMVKF-W-VCGSSNGALSLWITENSTGPEGQRSLWNSTSEANMGKGWKLITLPLFGLV 612

Human   605 DRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELK---- 665
            |.|:||..|.....|....|.||.::|::|:|..:||...:...:| ::.||.:: |:.:|
Zfish   613 DLFYLQFSADISSSSGIAFAVDNFTLSMECFLETNGEFPPVAPISP-TQALFTQS-NENIKTTTT 675

Human   666 ----PGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIW 726
                ||.::        .:|.|:|.||||:|..|||..||:|:|:|:|::|.||::||.||||:|
Zfish   676 LYGGPGAST--------ESVKWIFHTCGATGQDGPTPTQCSNSYRNTNVNVTVGTKGPFKGIQMW 732

Human   727 KVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQ 791
            :||.|..|.|:.||||||: ....:.:||||.:.|.|.|:||::|||||||:||||||:....:.
Zfish   733 QVPETRKYRITAYGAAGGR-SVLAVHKSHGVYMTGDFLLQKDELLYILVGQEGEDACPNMVPTMD 796

Human   792 KVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTF 856
            ::|..:...     .:|::  :..||||||||.|||||:.:||.:||:||||||||.|.::::|
Zfish   797 RICREQQGP-----SINKT--QLKGGGGGGGGGTYVFKVVNGVHIPLLIAAGGGGRGYSSQSET- 853

Human   857 HPER-LENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGG 920
             ||. ::.:.|:.|.||.||.|||||||||:..:...|:.|..|..||..| |||   ||:||||
Zfish   854 -PEEVMDRDPSIPGRNGKSGTAGGGGGWNDSAPVPQGGRPLILGGQGGEPC-QAM---GWKTRGG 913

Human   921 FGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYL 985
            ||||||.|::|||||||.||:|..:|||..||:||.|:|||.|.:|...||.|||:|||.|....
Zfish   914 FGGGGGACTAGGGGGGYRGGSAWHDNDPRKDGDDGTSYISPDGEMYLEPLKGMEGNGEVIINPVQ 978

Human   986 NCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLP-------LSLILSVVTSA 1043
            ||||||..:||...|.  ::|:||....||.||||||.| |..|.||       |:|.|||.|||
Zfish   979 NCSHCESGDCHETSEG--MVCYCDEELTLAPDGVSCINS-TELPLLPAQPSLSHLALGLSVGTSA 1040

Human  1044 LVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDL 1108
            |:|||:||.||:||:|||||.|||::|:|||||:.||||||.|||||||||||||.|||:|::||
Zfish  1041 LIAALLLAVSGVMIMYRRKHTELQSIQLELQSPDCKLSKLRASTIMTDYNPNYCFGGKTASVNDL 1105

Human  1109 KEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISK 1173
            |||||:||:|.||||||||||||||...|:|.:|||:||||||||||||||||||||||||||||
Zfish  1106 KEVPRRNISLTRGLGHGAFGEVYEGLAVGIPGEPSPMQVAVKTLPEVCSEQDELDFLMEALIISK 1170

Human  1174 FNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQ 1238
            |:|||||||||||||:||.||||||||||||||||||||||...||||.|:|||::|||||.|||
Zfish  1171 FSHQNIVRCIGVSLQALPHFILLELMAGGDLKSFLRETRPRLEHPSSLTMVDLLNIARDIARGCQ 1235

Human  1239 YLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFME 1303
            |||||.|||||||||||||||.|||||||||||||||||||||||||||.|||||||||||||||
Zfish  1236 YLEENQFIHRDIAARNCLLTCKGPGRVAKIGDFGMARDIYRASYYRKGGRAMLPVKWMPPEAFME 1300

Human  1304 GIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQH 1368
            |||||||||||||||||||||||||||||:||||||||||:||||||||||||||||||||.|||
Zfish  1301 GIFTSKTDTWSFGVLLWEIFSLGYMPYPSRSNQEVLEFVTNGGRMDPPKNCPGPVYRIMTQSWQH 1365

Human  1369 QPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDP------------EGV 1421
            ||||||||:.|||||:||.|||||:|..||:||||:.||||:||:||:||            |.|
Zfish  1366 QPEDRPNFSTILERIDYCLQDPDVVNVPLPVEYGPIPEEEERVPMRPEDPSAPSLLVSPQGTEDV 1430

Human  1422 PPLLVSQQAKREEE-----------RSPAAPP---------PLPTTSSGKAAKKPTAAEISVRVP 1466
            |....|.|:|::.|           :.|..||         ..|..::...|.||::...:
Zfish  1431 PSATHSAQSKKDGEAIHMANLSTDSKLPPVPPSQPHPHHHLQTPVVTAPVPASKPSSTTSN---- 1491

Human  1467 RGPAVEGGHVNMAFSQSNPPSELHKVHGSRN-KPTSLWNPTYGSWFTEKPTKKNNPIAKKE---P 1527
               |.:|||||:.|.|::...:     .||| |||:||||||||||.::..|:....|:::   |
Zfish  1492 ---AQDGGHVNLGFMQAHSSEK-----ESRNRKPTNLWNPTYGSWFLQQQQKRQQVQAQRQTSGP 1548

Human  1528 HDRGN--------------LGL--------------------------EGSC--TVPPNVATGRL 1550
            ...|.              |||                          :|.|  .:||.......
Zfish  1549 RIPGEGQEQVGRTVTVAEALGLQQQHKQQQYQQQLQRQQQQQQQQQQQQGLCRPLLPPPPPPAPT 1613

Human  1551 PGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAP 1599
            |   |||:    :|.:..|||:|||.|||||:.||||:||||:|....|
Zfish  1614 P---LLLD----SATLAPVPLYRLRRFPCGNIGYGYQEQGLPMEPMQGP 1655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALK	NP_004295.2	Heparin-binding region. /evidence=ECO:0000269|PubMed:34646012	48..70		13/21 (62%)
		MAM	266..424	CDD:99706	39/160 (24%)
		LDLa	441..467	CDD:197566	10/25 (40%)
		MAM	480..635	CDD:459878	47/160 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	650..674		7/31 (23%)
		EGF-like. /evidence=ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673	987..1025		19/37 (51%)
		FXa_inhibition	987..1021	CDD:464251	16/33 (48%)
		PTKc_ALK_LTK	1109..1385	CDD:270632	246/275 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1408..1463		22/86 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1514..1540		9/70 (13%)
alk	NP_001410894.1	Heparin-binding region. /evidence=ECO:0000250|UniProtKB:Q9UM73	54..76		13/21 (62%)
		LDLa	449..475	CDD:197566	10/25 (40%)
		MAM	488..639	CDD:99706	46/156 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	842..892		24/51 (47%)
		EGF-like. /evidence=ECO:0000250|UniProtKB:Q9UM73	980..1016		20/38 (53%)
		FXa_inhibition	980..1012	CDD:464251	16/33 (48%)
		PTKc_ALK_LTK	1106..1382	CDD:270632	246/275 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1395..1499		33/110 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1505..1524		9/23 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1532..1557		4/24 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1588..1613		4/24 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1646..1681		5/10 (50%)