Protein Alignment ALK and Alk

DIOPT Version :10

• Sequence 1: NP_004295.2
• Gene: ALK / 238
• HGNCID: 427
• Length: 1620
• Species: Homo sapiens
• Sequence 2: NP_652600.1
• Gene: Alk / 53425
• FlyBaseID: FBgn0040505
• Length: 1701
• Species: Drosophila melanogaster
• Alignment Length: 1657
• Identity: 525/1657 - (31%)
• Similarity: 740/1657 - (44%)
• Gaps: 297/1657 - (17%)

Human   103 GPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRA-------KQLVLELGEEAILEGCVGPPGE 160
            ||..|:| ..||..|:.:.|.|.....|..:.|..|       .||....|..|:..|.:|.|..
  Fly   128 GPGGGIS-GGGSGYPSYSATSSIGRIDGLGQGLGSADRYGALYDQLRQPSGMAAMTAGPLGGPYS 191

Human   161 AAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEK--KASEVGREGRLSAAI-RASQPRLLFQIFGT 222
            .....|...:.:                 .|::  :.:.:....:|..|: :|.:|     ..|.
  Fly   192 TRFPPLYAGVDD-----------------QPKRSNRKNSISELYKLKKALNQADEP-----AGGV 234

Human   223 GHSSLESPTNMPSP----------------SPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFP 271
            .|.:.|..   |.|                ||:..|:.   ...|:.|...:....|::|:|:.|
  Fly   235 THGNFEGD---PQPSSADPLQEIKDRIRDTSPNANTYA---PHTDATPSSEYEYELGVKCNFETP 293

Human   272 CELEYSPPLHDLRNQSWSW-------RRIPSEEASQMD---LLDGPGAERSKEMPRGSFLLLNTS 326
            |              ||:|       :.|...|.|:.:   ||.||.|: |.:...|.||....:
  Fly   294 C--------------SWTWGNYSDGFQVITGTELSKRNLTGLLPGPAAD-SIDDANGHFLYARVN 343

Human   327 ADSKH-TILSPWMRSSSEHCTLAVSVHRHLQPSG--RYIAQLLPHNEAA---REILLMPTPGKHG 385
            ..|:. .:.||...::.|.|.|.|.:|:.....|  |.:.:||...|::   .|||   ......
  Fly   344 PSSRPLNLTSPEFSTTMEKCFLEVYMHQSDMSHGLSRVVVELLHTAESSWVPAEIL---GDNVRQ 405

Human   386 WTVLQGRIGRPDNPFRVALEYISS---GNRSLSAVDFFALKNC-SEGTSPGSKMALQSSFTCWNG 446
            ||....|:||....||:..|.:..   |.:...|:|...:.|| .|||.  |:....|...|.:.
  Fly   406 WTRKVYRLGRVSRDFRIVFEVVPDLRVGQKGHVALDNLRMVNCFPEGTK--SEKCSTSQVKCTSS 468

Human   447 TV---LQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGW-----TQGTLSPHT---PQ 500
            .|   :.|.:.||..:||.:.|||.|.|.|:|.|..|:||:.:|||     |..|.|.||   |.
  Fly   469 KVPVCIHLPRICDITRDCDEAEDEQQSCDKIPYGGRCDFEEDWCGWRDSGKTTLTWSRHTGSSPT 533

Human   501 WQVRTLKDARFQDHQDHA----LLLSTTD----------VPASESATVTSATF--PAPIKSSP-C 548
            .......|...|..|::.    :|::...          :..:.:|.:.|.||  |..:..:| .
  Fly   534 HDTGPDGDHTMQHLQNNTSGYYMLVNMNQHMNNSEKNSIIGFASNAIMVSKTFNPPPSVHGNPDS 598

Human   549 ELRMSWLIR------GVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWM----VLPLLDV 603
            ..|.|.::|      |...|:::|.:||.|..:.....:|.....:|.   .||    |||  ::
  Fly   599 PYRNSCVVRFFIHQFGKNPGSINLSVVEMKEKENITTTLWWSTKNQGS---DWMRAEYVLP--NI 658

Human   604 SDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGE 668
            :.:::||..|..|....:.||.|:.|:|.:|:.....||.:      ...|.::...|  ||
  Fly   659 TSKYYLQFEARMGMRIYSDVAVDDFSLSPECFGLNIPEDHL------GGYNYWDVRQN--LK--- 712

Human   669 NSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLS--------VEVGSEGPLKGIQI 725
             ||.... |:.|.:...|||...|..||:||||..||:..|.:        ||  .:...||:|.
  Fly   713 -SPTYKD-FEYTNYLELTTCDTRGMIGPSQAQCEAAYREQNKTHVLREVHVVE--DQSSYKGMQK 773

Human   726 WKVPATDTYSISGYGAAG--GKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQ 788
            ||||....|:|...||:|  |.||..:   |.|...:.|..|.|::.||.|||||||:||..:..
  Fly   774 WKVPHEGHYTIIAKGASGGLGSGGVGS---SRGSVAVAILELHKNEELYFLVGQQGENACIKSMG 835

Human   789 LIQKVCIGENNVIEEEIRVNRSVHEWA------GGGGGGGGATYVFKMKD--GVPVPLIIAAGGG 845
            ::::...|.::.::......||..:..      .|.|||||.:|||.:..  ...|||::|.|||
  Fly   836 VLKEAGCGTDHDLDLAQYSFRSKQDMVKNIYIENGAGGGGGGSYVFLLNQAKNEAVPLLVAGGGG 900

Human   846 GRAYGAKTD-------TFHPERLENNSSVLGLNGNSGAAGGGGGW---NDNTSLLWAGKSLQEGA 900
            |...|...|       ...|.:...:..:.|...|...||.||||   .|.......|.:|.:|.
  Fly   901 GLGIGQYIDEDFQHGQKAKPLQAPESGQINGEPLNKKTAGPGGGWRAKEDQALSPTYGAALLQGG 965

Human   901 TGGHSCPQAMKKWGWET----RGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISP 961
            .|||||...:...|...    :||||||||||::|||||||.||:....   |.:||.|.|:|||
  Fly   966 RGGHSCYVELADNGTSVHRHGQGGFGGGGGGCNTGGGGGGYAGGDVYLT---ESNGEGGSSYISP 1027

Human   962 L------------------GILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFC 1008
            .                  .|:..||:   ||.|            |:.....:|....||.|.|
  Fly  1028 SRSLREISEIHAGASSGPGAIIIIPAI---EGCG------------CDYRCVALDEFRSKVRCIC 1077

Human  1009 DHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIV----YRRKHQELQAM 1069
            ..|..|..|..:...............::|::..:| |.|.:..:.::.:    |:||.|..:..
  Fly  1078 PDGWSLKRDNHTACEIREEAGKSSFQYLVSILMISL-AVLFICIAALIFMLYNRYQRKKQSKKRH 1141

Human  1070 QMELQSPEYKLSKLRTS---TIMTDYNPNYCFAGKTS---SISDLKEVPRKNITLIRGLGHGAFG 1128
            :| |...:.:|::||.:   :.:.::||||...|..:   .::.|.:|.|.::.|:..||.||||
  Fly  1142 KM-LVEQDLQLTRLRNNIDDSNLNNFNPNYGCDGILNGHIDVNSLPQVARDSLQLVNALGKGAFG 1205

Human  1129 EVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRF 1193
            |||.........|...:.||||||.|....:.|.|||.||.|::||||.|:|..|||.....|.:
  Fly  1206 EVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYY 1270

Human  1194 ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLT 1258
            |:|||:|||||:.||||.|..|.:||.|.|.|||..|.|:|.||:|:|...|||||||||||||:
  Fly  1271 IVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLS 1335

Human  1259 CPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIF 1323
            ..|||||.||.||||:|||||:.||||||.||||:||||||||::||||||||.||||:||||:|
  Fly  1336 SKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVF 1400

Human  1324 SLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQ 1388
            |||..|||.:.|.:|:|.|..|||:..|..||..:|::|..||...|||||.|..:||.:..|||
  Fly  1401 SLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTACTQ 1465

Human  1389 DPDVINTALPIEYGPLVEEEEKVPVRPKDPE----GVPPLLVSQQAKREEERSPAAPPPLPTTSS 1449
            |..::|..||...||...|.:...:||.:.|    .||..||                |||...|
  Fly  1466 DASIMNAPLPNILGPTASERDDTVIRPPNGEEFCLAVPDYLV----------------PLPPGGS 1514

Human  1450 GKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGS-WFTE 1513
                ..|:.|..|..||.       ......|...||: :........:|.....||.|. |.|.
  Fly  1515 ----NNPSMASGSGYVPE-------LQRQQMSSCTPPA-VTSPAAPHPRPVENIAPTSGDCWETS 1567

Human  1514 --KPTKKNNPIAKKEPHDRGNLGLEGSCTV-------------PPNVATGRLPGASLLLEPSSLT 1563
              .|..|..|......||....|.|.:..:             ||.....:|.|  :.|:||:||
  Fly  1568 FILPNSKVEPPVVGSGHDVPLAGGEEAKLISLDTPQPTPTTIQPPLSFASQLDG--ITLDPSALT 1630

Human  1564 ANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEA 1595
            .::           |.||....|....:..||
  Fly  1631 KSL-----------PNGNAKQSYANVQVKNEA 1651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALK	NP_004295.2	Heparin-binding region. /evidence=ECO:0000269|PubMed:34646012	48..70
		MAM	266..424	CDD:99706	46/176 (26%)
		LDLa	441..467	CDD:197566	8/28 (29%)
		MAM	480..635	CDD:459878	47/189 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	650..674		6/23 (26%)
		EGF-like. /evidence=ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673	987..1025		9/37 (24%)
		FXa_inhibition	987..1021	CDD:464251	9/33 (27%)
		PTKc_ALK_LTK	1109..1385	CDD:270632	158/275 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1408..1463		13/58 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1514..1540		7/25 (28%)
Alk	NP_652600.1	MAM	288..447	CDD:99706	46/176 (26%)
		MAM	505..689	CDD:99706	47/188 (25%)
		PTKc_ALK_LTK	1186..1462	CDD:270632	158/275 (57%)