DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ALK and Tak1

DIOPT Version :9

Sequence 1:NP_004295.2 Gene:ALK / 238 HGNCID:427 Length:1620 Species:Homo sapiens
Sequence 2:NP_524080.1 Gene:Tak1 / 39659 FlyBaseID:FBgn0026323 Length:678 Species:Drosophila melanogaster


Alignment Length:464 Identity:119/464 - (25%)
Similarity:192/464 - (41%) Gaps:91/464 - (19%)


- Green bases have known domain annotations that are detailed below.


Human  1102 TSSISDLKE--VPRKNITLIRGLGHGAFG----EVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQD 1160
            |:|:..|:.  |....|||...:|||::|    .|:..::           ||||   |..:..:
  Fly     3 TASLDALQAAYVDFSEITLREKVGHGSYGVVCKAVWRDKL-----------VAVK---EFFASAE 53

Human  1161 ELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLR-ETRPRPSQPSSLAML 1224
            :.|...|...:|:..|.||:...|:|......::::|...||.|.:||. :.:|..|...:::. 
  Fly    54 QKDIEKEVKQLSRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSW- 117

Human  1225 DLLHVARDIACGCQYLE---ENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKG 1286
                 ||..|.|..||.   ....||||:...|.|||  ..||..||.|||...|........:|
  Fly   118 -----ARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLT--NKGRNLKICDFGTVADKSTMMTNNRG 175

Human  1287 GCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEF-VTSGGRMDP 1350
            ..|     ||.||.|....:|.|.|.:|:.::|||:.| ...|:....|...::: :..|.|  |
  Fly   176 SAA-----WMAPEVFEGSKYTEKCDIFSWAIVLWEVLS-RKQPFKGIDNAYTIQWKIYKGER--P 232

Human  1351 P--KNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPV 1413
            |  ..||..:..:||.||:..|||||:...|:..:....:|....:.||  || ..|.::    :
  Fly   233 PLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVMHEIVKDYTGADKAL--EY-TFVNQQ----I 290

Human  1414 RPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGK-----AAKKPTAAEISVRVPRGPAVEG 1473
            ..|:.:|.........:.:|.|.||::....|||::..     |..|.|.:              
  Fly   291 VTKESDGTVAAQPDSLSSQEGELSPSSTQLTPTTAANANVNAIAISKTTTS-------------- 341

Human  1474 GHVNMAFSQSNPPSELHKVHGSR--NKP-----TSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRG 1531
               :|..:.|:..|::...:..:  |.|     |:.|:..        |.:::|    :..:|..
  Fly   342 ---SMTENTSSTSSDITPTNSGQLDNNPLFYMVTNRWDAI--------PEEESN----ESRNDSF 391

Human  1532 NLGLEGSCT 1540
            ||......|
  Fly   392 NLTSSAEAT 400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ALKNP_004295.2 MAM 266..427 CDD:279023
MAM 266..424 CDD:99706
LDLa 441..467 CDD:197566
MAM 480..636 CDD:279023
MAM 480..631 CDD:99706
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 650..674
FXa_inhibition 987..1021 CDD:291342
PTKc_ALK_LTK 1109..1385 CDD:270632 85/288 (30%)
Pkinase_Tyr 1116..1383 CDD:285015 84/277 (30%)
Inhibitor binding 1197..1199 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1408..1463 12/59 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1514..1540 5/25 (20%)
Tak1NP_524080.1 TyrKc 19..264 CDD:197581 83/274 (30%)
STKc_TAK1 25..275 CDD:270960 82/279 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.