DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ALK and btl

DIOPT Version :10

Sequence 1:NP_004295.2 Gene:ALK / 238 HGNCID:427 Length:1620 Species:Homo sapiens
Sequence 2:NP_729956.1 Gene:btl / 39564 FlyBaseID:FBgn0285896 Length:1052 Species:Drosophila melanogaster


Alignment Length:479 Identity:145/479 - (30%)
Similarity:224/479 - (46%) Gaps:79/479 - (16%)


- Green bases have known domain annotations that are detailed below.


Human  1005 ICFCDHG--TVLAEDGVS--------CIVSPTPEPHL-------PLSLILSVVTSALVAALVLAF 1052
            :.|...|  |.||..|:.        .:|||.|...:       ||...|:.:|  :||..:|..
  Fly   556 VTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAIT--IVALFLLGS 618

Human  1053 SGIMIVYRR-KHQELQAMQME--------------------------LQSPEYKLSKLRTSTIMT 1090
            :.|..:.|| :.::|..:::|                          ||.|..::.|.||:...|
  Fly   619 AFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTT 683

Human  1091 ---DYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQ--VAVK 1150
               ..:|...|......:....|:||:.::|...||.||||.|...:..|:|..|...:  ||||
  Fly   684 GTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVK 748

Human  1151 TLPEVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPR 1214
            .:.|..::.|....:.|..::... .|.||:..:|...|..|.::::|....|:||.||::.||.
  Fly   749 MVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPG 813

Human  1215 PSQPSS----------------LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG 1263
            ..|..|                |...:|...|..||.|.:||.....||||:||||.|::   .|
  Fly   814 APQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVS---DG 875

Human  1264 RVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYM 1328
            .|.||.|||:||||....||||.....||:|||.||:..|..:.|::|.||:|||||||.:.|..
  Fly   876 YVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQ 940

Human  1329 PYPS-KSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILER----IEYCTQ 1388
            |||. .|.:|:..::.:|.||:.|..|...:|.:|.|||..:...||.||.::|.    ::..:.
  Fly   941 PYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASS 1005

Human  1389 DPD--VINTALP-IEYGPLVEEEE 1409
            :|:  .::.::| :|..|...:|:
  Fly  1006 NPNDAYLDLSMPMLETPPSSGDED 1029

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ALKNP_004295.2 Heparin-binding region. /evidence=ECO:0000269|PubMed:34646012 48..70
MAM 266..424 CDD:99706
LDLa 441..467 CDD:197566
MAM 480..635 CDD:459878
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 650..674
EGF-like. /evidence=ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673 987..1025 7/29 (24%)
FXa_inhibition 987..1021 CDD:464251 6/25 (24%)
PTKc_ALK_LTK 1109..1385 CDD:270632 109/299 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1408..1463 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1514..1540
btlNP_729956.1 Ig 143..215 CDD:472250
Ig strand B 160..164 CDD:409570
Ig strand C 175..179 CDD:409570
Ig strand E 197..201 CDD:409570
Ig strand F 211..215 CDD:409570
Ig_3 247..333 CDD:464046
Ig 398..479 CDD:472250
Ig strand B 412..416 CDD:409393
Ig strand C 423..427 CDD:409393
Ig strand E 445..449 CDD:409393
Ig strand F 459..464 CDD:409393
Ig strand G 472..475 CDD:409393
IG_like 492..583 CDD:214653 6/26 (23%)
Ig strand B 503..507 CDD:409444
Ig strand C 516..520 CDD:409444
Ig strand E 549..553 CDD:409444
Ig strand F 563..568 CDD:409444 1/4 (25%)
Ig strand G 576..579 CDD:409444 0/2 (0%)
Protein Kinases, catalytic domain 700..1000 CDD:473864 109/302 (36%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.