DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ALK and Tie

DIOPT Version :10

Sequence 1:NP_004295.2 Gene:ALK / 238 HGNCID:427 Length:1620 Species:Homo sapiens
Sequence 2:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster


Alignment Length:390 Identity:124/390 - (31%)
Similarity:175/390 - (44%) Gaps:90/390 - (23%)


- Green bases have known domain annotations that are detailed below.


Human  1061 RKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHG 1125
            :.||..|||.|. |:.:...:..|       |..|   ..|||..|:..:..|.||.|...||.|
  Fly   810 QNHQHHQAMPMS-QASQRDANHNR-------YGNN---DDKTSLASEFHDFERSNIRLKSLLGEG 863

Human  1126 AFGEVYEGQVSGMPNDPSPLQ-VAVKTLPEVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQ 1188
            .||:|::.:...:.......: |||||: ..||.|..|.  .||.|:.|. :|||:|..:|..::
  Fly   864 NFGQVWKAEADDLSGHFGATRIVAVKTI-RACSAQVSLK--DEANIMRKLGSHQNVVTLLGACVE 925

Human  1189 SLPRFILLELMAGGDLKSFLRETRPR-----PSQPS--SLAMLD---LLHVARDIACGCQYLEEN 1243
            |.|..:::|....|.|.|.||..|..     .|.|.  |||.|.   |...|.|||||.:|:...
  Fly   926 SEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGR 990

Human  1244 HFIHRDIAARNCLLTCPGPGRVAKIGDFGM-----------------ARDIYRASYYR------- 1284
            ..:|||:||||.||...|   :.||.||||                 |.|:.|.:.::       
  Fly   991 RIVHRDLAARNVLLDHNG---MCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGS 1052

Human  1285 ----------------KGGCA---------------------MLPVKWMPPEAFMEGIFTSKTDT 1312
                            :|.|:                     .||::||.||:....:||::||.
  Fly  1053 RYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDI 1117

Human  1313 WSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFA 1377
            |:||::||||.:||..||...:.:||:..|..|.|.|.||......|.:|::||..:|..||:||
  Fly  1118 WAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFA 1182

Human  1378  1377
              Fly  1183  1182

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ALKNP_004295.2 Heparin-binding region. /evidence=ECO:0000269|PubMed:34646012 48..70
MAM 266..424 CDD:99706
LDLa 441..467 CDD:197566
MAM 480..635 CDD:459878
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 650..674
EGF-like. /evidence=ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673 987..1025
FXa_inhibition 987..1021 CDD:464251
PTKc_ALK_LTK 1109..1385 CDD:270632 110/342 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1408..1463
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1514..1540
TieNP_523928.1 TyrKc 854..1183 CDD:197581 108/335 (32%)
Blue background indicates that the domain is not in the aligned region.

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