Protein Alignment ALK and Egfr

DIOPT Version :10

• Sequence 1: NP_004295.2
• Gene: ALK / 238
• HGNCID: 427
• Length: 1620
• Species: Homo sapiens
• Sequence 2: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Alignment Length: 665
• Identity: 164/665 - (24%)
• Similarity: 273/665 - (41%)
• Gaps: 145/665 - (21%)

Human   986 NC-SHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSL---ILSVVTSALVA 1046
            || |.|.::..|::.:...:             |..|..||.....:..:|   ::.::|.|::.
  Fly   828 NCTSKCPLEMRHVNYQYTAI-------------GPYCAASPPRSSKITANLDVNMIFIITGAVLV 879

Human  1047 ALVLAFSGIMIVYRRKH---QELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDL 1108
            ..:.....:..:.|:|.   :|...|.|.|...| ....||.|.|    ..|.|         .|
  Fly   880 PTICILCVVTYICRQKQKAKKETVKMTMALSGCE-DSEPLRPSNI----GANLC---------KL 930

Human  1109 KEVPRKNITLIRG--LGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALII 1171
            :.|  |:..|.:|  ||.||||.||:| |.....:...:.||:|.|.:....:...:||.||.|:
  Fly   931 RIV--KDAELRKGGVLGMGAFGRVYKG-VWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIM 992

Human  1172 SKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACG 1236
            :...|.|:::.:.|.:.| ...::.:||..|.|..::|..|.:      :....||:.:..||.|
  Fly   993 ASVEHVNLLKLLAVCMSS-QMMLITQLMPLGCLLDYVRNNRDK------IGSKALLNWSTQIAKG 1050

Human  1237 CQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAF 1301
            ..||||...:|||:||||.|:..|.   :.||.|||:|:.:...|...|.....:|:||:..|..
  Fly  1051 MSYLEEKRLVHRDLAARNVLVQTPS---LVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECI 1112

Human  1302 MEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCW 1366
            ...:||||:|.|:|||.:||:.:.|..|:.:...:::.:.:..|.:::.|:.|...:|..:..||
  Fly  1113 RNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCW 1177

Human  1367 QHQPEDRPNFAIILERIEYCTQDP--------DVINTALPIEYGPLVEEEEKVPVRPKDP--EGV 1421
            ......||.|..:........:||        |.. |.||    ....::||..:|...|  :|.
  Fly  1178 HLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKF-TRLP----AYTSQDEKDLIRKLAPTTDGS 1237

Human  1422 PPLLVSQQAKREEERSP-AAPPP---------LP------------TTSSGKAAKKPTAAEISVR 1464
            ..:     |:.::...| |||.|         :|            .:|:|......:|.|:.|.
  Fly  1238 EAI-----AEPDDYLQPKAAPGPSHRTDCTDEIPKLNRYCKDPSNKNSSTGDDETDSSAREVGVG 1297

Human  1465 VPR--GPAVEGGHVNMAFSQSNPPSELHKVHGSRNK----------------PTSLWNPTY---- 1507
            ..|  .|..|..:: |...|..|.:..:..:.::|.                |.|:.||.|
  Fly  1298 NLRLDLPVDEDDYL-MPTCQPGPNNNNNINNPNQNNMAAVGVAAGYMDLIGVPVSVDNPEYLLNA 1361

Human  1508 ---GSWFTEKPTKK-NNPIAKKEPHDRGNLGLEGSCTVP-PNVATGRLPGASLLLEPSS-----L 1562
               |...:..||:. ..|:          :|:.|:..|. |      :||:    ||:|     .
  Fly  1362 QTLGVGESPIPTQTIGIPV----------MGVPGTMEVKVP------MPGS----EPTSSDHEYY 1406

Human  1563 TANMKEV-PLFRLRH 1576
            ....:|: ||.|.|:
  Fly  1407 NDTQRELQPLHRNRN 1421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALK	NP_004295.2	Heparin-binding region. /evidence=ECO:0000269|PubMed:34646012	48..70
		MAM	266..424	CDD:99706
		LDLa	441..467	CDD:197566
		MAM	480..635	CDD:459878
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	650..674
		EGF-like. /evidence=ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673	987..1025		6/38 (16%)
		FXa_inhibition	987..1021	CDD:464251	5/34 (15%)
		PTKc_ALK_LTK	1109..1385	CDD:270632	85/277 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1408..1463		16/78 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1514..1540		5/26 (19%)
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614
		Recep_L_domain	419..547	CDD:460032
		GF_recep_IV	572..684	CDD:464344
		FU	662..716	CDD:214589
		GF_recep_IV	740..>834	CDD:464344	3/5 (60%)
		PTKc_EGFR_like	930..1208	CDD:270648	88/290 (30%)