DRSC/TRiP Functional Genomics Resources

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Protein Alignment ALK and Ddr

DIOPT Version :10

Sequence 1:NP_004295.2 Gene:ALK / 238 HGNCID:427 Length:1620 Species:Homo sapiens
Sequence 2:NP_001014474.3 Gene:Ddr / 3346209 FlyBaseID:FBgn0053531 Length:1054 Species:Drosophila melanogaster


Alignment Length:471 Identity:119/471 - (25%)
Similarity:195/471 - (41%) Gaps:89/471 - (18%)


- Green bases have known domain annotations that are detailed below.


Human   925 GGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSH 989
            |.||.:|.|.|   .|..:|                       |...|..|....:.::.||.:.
  Fly   631 GSGCGTGTGTG---PGRGSS-----------------------PEFVVATGKVTASARNSLNAAT 669

Human   990 CEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSG 1054
            ..:....:.|...|..             .:..||..|.|..|.....|...|:...|.....||
  Fly   670 LPLPSPPVPPPLEKYY-------------AATPVSSKPMPVAPPGSQSSGSLSSSTTAATTPTSG 721

Human  1055 IMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLI 1119
            ::.|.:..|..|                        |.:.|:....:..:...::|.||:::.::
  Fly   722 VVGVGKPHHYNL------------------------DMSANFADINEERANCQVQEFPRQSLVIV 762

Human  1120 RGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIG 1184
            ..||.|.|||::..:.    |..:...|||.||....::....:|..:|..:::.:..|:.|.:|
  Fly   763 EKLGSGVFGELHLCET----NVLNATLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVG 823

Human  1185 VSLQSLPRFILLELM-AGGDLKSFLRETRPRPS---QPSSLAMLDLLHVARDIACGCQYLEENHF 1245
            ..|:..|..|:.:.. ..|||..||:|.....|   ...||:...|:::|..||.|.::||:.:|
  Fly   824 ACLRDEPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKSLSFGCLVYIATQIASGMKHLEQMNF 888

Human  1246 IHRDIAARNCLLTCPGPGRVAKIGDFG--MARDIYRASYYRKGG-----CAMLPVKWMPPEAFME 1303
            :|||:|.|:|::   ||....|:...|  :.|..|.:.|.:..|     ...:|::||..|:.:.
  Fly   889 VHRDLATRSCII---GPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVLL 950

Human  1304 GIFTSKTDTWSFGVLLWEIFSLG-YMPYPSKSNQEVLEFVTSGGR-------MDPPKNCPGPVYR 1360
            |.||:|:|.|||.|.||||.:.. ..||...|::.|:|.:....|       :..|.|||..:|.
  Fly   951 GKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYD 1015

Human  1361 IMTQCWQHQPEDRPNF 1376
            :|.:|||.....||:|
  Fly  1016 LMCECWQRDESSRPSF 1031

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ALKNP_004295.2 Heparin-binding region. /evidence=ECO:0000269|PubMed:34646012 48..70
MAM 266..424 CDD:99706
LDLa 441..467 CDD:197566
MAM 480..635 CDD:459878
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 650..674
EGF-like. /evidence=ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673 987..1025 3/37 (8%)
FXa_inhibition 987..1021 CDD:464251 2/33 (6%)
PTKc_ALK_LTK 1109..1385 CDD:270632 89/287 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1408..1463
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1514..1540
DdrNP_001014474.3 FA58C 109..261 CDD:238014
PTKc_DDR 753..1040 CDD:270644 89/286 (31%)
Blue background indicates that the domain is not in the aligned region.

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