DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ALK and sev

DIOPT Version :9

Sequence 1:	NP_004295.2	Gene:	ALK / 238	HGNCID:	427	Length:	1620	Species:	Homo sapiens
Sequence 2:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster

Alignment Length:	1608	Identity:	376/1608 - (23%)
Similarity:	568/1608 - (35%)	Gaps:	557/1608 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    48 RLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTA 112
            |||...|:..|         ||...||.:..:||                    :...|..:|.:
  Fly  1242 RLQTLDLSTPF---------ARLTQLPQAQLQLK--------------------ISITPRTAWRS 1277

Human   113 GSP----------APAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPG-EAAVGLL 166
            |..          ||::.|.| ||.    |.:|..|.|   |....|:|.......| ||.:..|
  Fly  1278 GDTTRVQLTTPPVAPSQPRRL-RVF----VERLATALQ---EANVSAVLRWDAPEQGQEAPMQAL 1334

Human   167 QFNLSELFSWWI--------RQGEGRLRIR---LMPE---------KKASEVGREGRLSAAIRAS 211
            ::::    |.|:        |..:..|..|   |.|:         :.|:.....|..|.|:..:
  Fly  1335 EYHI----SCWVGSELHEELRLNQSALEARVEHLQPDQTYHFQVEARVAATGAAAGAASHALHVA 1395

Human   212 Q-----PRLLF---QIFG-------------------------TGHSSL-------ESPTNMPSP 236
            .     ||:|:   :..|                         .|...|       |..|::|..
  Fly  1396 PEVQAVPRVLYANAEFIGELDLDTRNRRRLVHTASPVEHLVGIEGEQRLLWVNEHVELLTHVPGS 1460

Human   237 SP--------DYFTWNLTWIMKDSF--------PFLSHRSRYGLECSFD---FPCELEYSPP--- 279
            :|        :.....:.||.:..:        |..:...|..| |:|:   ...|..:|.|
  Fly  1461 APAKLARMRAEVLALAVDWIQRIVYWAELDATAPQAAIIYRLDL-CNFEGKILQGERVWSTPRGR 1524

Human   280 -LHDL----RNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFL-------LLNTSADSKHT 332
             |.||    :.||..|  :..|:.|..:     |:.|.:.:..||.|       |:...|.|
  Fly  1525 LLKDLVALPQAQSLIW--LEYEQGSPRN-----GSLRGRNLTDGSELEWATVQPLIRLHAGS--- 1579

Human   333 ILSPWMRSSSEHCTL--------AVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPG----KHG 385
             |.|    .||...|        ...|.|.|..:....|||....|.:....|....|    ...
  Fly  1580 -LEP----GSETLNLVDNQGKLCVYDVARQLCTASALRAQLNLLGEDSIAGQLAQDSGYLYAVKN 1639

Human   386 WTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFAL--KNCSEGTSPGSKMALQSSFTCWNGTV 448
            |::  ...||........:|......|.|.|.::.|.  |||         :.|.||    .|::
  Fly  1640 WSI--RAYGRRRQQLEYTVELEPEEVRLLQAHNYQAYPPKNC---------LLLPSS----GGSL 1689

Human   449 LQL----GQACDFH-------QDC-----------------AQGEDESQMCRKLPVGFYCNFEDG 485
            |:.    .|.|..|       :||                 ..|.:|.....: |:|
  Fly  1690 LKATDCEEQRCLLHLPMITASEDCPLPIPGVRYQLNLTLAKEPGSEEHDHGME-PLG-------- 1745

Human   486 FCGWTQGT--------LSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAP 542
              .|..|.        |.|.| :::|..:..:.:|    ..|.|.|..:...|..| .||| |:|
  Fly  1746 --QWLLGAGESLNLTDLLPFT-RYRVSGILSSFYQ----KKLALPTLVLAPLELLT-ASAT-PSP 1801

Human   543 IKS------SPCELRMSWLIRGVLRGN---VSLVLVENKTGKE-QGRMVWHVAAYE--------- 588
            .::      ||.||.:|||....||..   .:|...:...|:. |.|..|.  |:|
  Fly  1802 PRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWE--AHERRLETAGTH 1864

Human   589 ---------GLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKI 644
                     |.|||                                                  :
  Fly  1865 RLTGIKPGSGYSLW--------------------------------------------------V 1879

Human   645 LQNTAPKSRNLFERNPNK------ELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQC-- 701
            ..:..|...|..||...:      ||:..|..|     :..::.|    .|...|.|..|.:|
  Fly  1880 QAHATPTKSNSSERLHVRSFAELPELQLLELGP-----YSLSLTW----AGTPDPLGSLQLECRS 1935

Human   702 -------NNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYS---ISGYGAAGGKGGKNTMMRSHG 756
                   |.|..::.:.||     ||:       |.| .|.   :.||.|..|      ....||
  Fly  1936 SAEQLRRNVAGNHTKMVVE-----PLQ-------PRT-RYQCRLLLGYAATPG------APLYHG 1981

Human   757 VSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGG 821
            .:           .:|..:|.....  |...||        .::.||..||.     |....|
  Fly  1982 TA-----------EVYETLGDAPSQ--PGKPQL--------EHIAEEVFRVT-----WTAARG-- 2018

Human   822 GGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDN 886
                      :|.|:.|.     ...|..|::|.....|....:|             ||...
  Fly  2019 ----------NGAPIALY-----NLEALQARSDIRRRRRRRRRNS-------------GGSLE-- 2053

Human   887 TSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMD 951
             .|.||                                                     .:|.:.
  Fly  2054 -QLPWA-----------------------------------------------------EEPVVV 2064

Human   952 GEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICF------CDH 1010
            .:..:.|.:      |..|.                  |.|...|    |.:::.|      .:|
  Fly  2065 EDQWLDFCN------TTELS------------------CIVKSLH----SSRLLLFRVRARSLEH 2101

Human  1011 GTVLAEDGVSCIVSPTPEPHLPLSLILSVVT-SALVAALVLAFSGIMIVYRRKHQELQAMQMELQ 1074
            |.....:....:..|...|....||:|:::. :|:|::.|||...:..|.:|:.:..:.:|....
  Fly  2102 GWGPYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRP 2166

Human  1075 SPEYKLSKLRT-STIMTDYNPNYCFAGKTSSISDLKEVPRKN---ITLIRGLGHGAFGEVYEGQV 1135
            |....||.|:| ..:|...|..:   ..|.|.:|:..:|:.|   :.|:|.||.||||||||||:
  Fly  2167 SIWSNLSTLQTQQQLMAVRNRAF---STTLSDADIALLPQINWSQLKLLRFLGSGAFGEVYEGQL 2228

Human  1136 SGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMA 1200
            . ..:...|.:||:|:|.:..||..||  |.||.::|.|.|:|||..:|:...:....:::|.|.
  Fly  2229 K-TEDSEEPQRVAIKSLRKGASEFAEL--LQEAQLMSNFKHENIVCLVGICFDTESISLIMEHME 2290

Human  1201 GGDLKSFLRETR------PRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTC 1259
            .|||.|:||..|      |:|:  :.|::.:||.:..|:|.||.|||:.||:|||:|.||||:|
  Fly  2291 AGDLLSYLRAARATSTQEPQPT--AGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVT- 2352

Human  1260 PGPG-----RVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLL 1319
            ...|     |..||||||:|||||::.||||.|..:|||:||.||:.::|:||:::|.|:||||.
  Fly  2353 ESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLC 2417

Human  1320 WEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNF-------- 1376
            |||.:||..||.:::|.|||..|..|||:..|..|...:|.::..||:..|.:||:|
  Fly  2418 WEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLH 2482

Human  1377 --AIILERIEYCTQDPDVINTALPIEY-----GPLVEEEEKVPVRPKD 1417
              :..|.|.:..:...|.:.:....|:     |..:||..:...||:|
  Fly  2483 AISTDLRRTQMASATADTVVSCSRPEFKVRFDGQPLEEHREHNERPED 2530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ALK	NP_004295.2	MAM	266..427	CDD:279023	46/192 (24%)
		MAM	266..424	CDD:99706	43/189 (23%)
		LDLa	441..467	CDD:197566	8/53 (15%)
		MAM	480..636	CDD:279023	37/191 (19%)
		MAM	480..631	CDD:99706	37/186 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	650..674		8/29 (28%)
		FXa_inhibition	987..1021	CDD:291342	7/39 (18%)
		PTKc_ALK_LTK	1109..1385	CDD:270632	127/299 (42%)
		Pkinase_Tyr	1116..1383	CDD:285015	124/287 (43%)
		Inhibitor binding	1197..1199		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1408..1463		3/10 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1514..1540
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495	23/93 (25%)
		FN3	1799..1897	CDD:238020	26/149 (17%)
		FN3	1993..2111	CDD:238020	33/246 (13%)
		Pkinase_Tyr	2209..2481	CDD:285015	123/277 (44%)
		PTKc_c-ros	2213..2483	CDD:270640	122/275 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1095
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D27151at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820