Protein Alignment ALK and Alk

DIOPT Version :10

• Sequence 1: NP_004295.2
• Gene: ALK / 238
• HGNCID: 427
• Length: 1620
• Species: Homo sapiens
• Sequence 2: NP_031465.2
• Gene: Alk / 11682
• MGIID: 103305
• Length: 1621
• Species: Mus musculus
• Alignment Length: 110
• Identity: 25/110 - (22%)
• Similarity: 43/110 - (39%)
• Gaps: 28/110 - (25%)

Human   191 EAMLEQMVATNV--AVDAS--QRTMELLD-KNKASELPGSQVVFEDPSVQKQEDEETKNMYK--- 247
            :|:|.|.....:  |:|.|  :||....| |.||.|           :|:::.|...|.:::
Mouse   150 DAVLYQEAVQKITTALDESHQKRTAAFEDFKTKAFE-----------AVEEERDSSGKELWEEVT 203

Human   248 ---AMNLCVCYAASIGGTATLTGTGPNVVLLGQMQELFPDSKDVM 289
               ...:|.......|..|.|     .:.|:|.:....| .::||
Mouse   204 ARLGQEVCTFSLEVQGKVAAL-----KIALIGHLASAQP-PREVM 242

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALK	NP_004295.2	Heparin-binding region. /evidence=ECO:0000269|PubMed:34646012	48..70
		MAM	266..424	CDD:99706	5/24 (21%)
		LDLa	441..467	CDD:197566
		MAM	480..635	CDD:459878
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	650..674
		EGF-like. /evidence=ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673	987..1025
		FXa_inhibition	987..1021	CDD:464251
		PTKc_ALK_LTK	1109..1385	CDD:270632
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1408..1463
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1514..1540
Alk	NP_031465.2	Heparin-binding region. /evidence=ECO:0000250|UniProtKB:Q9UM73	48..70
		MAM	270..428	CDD:99706
		LDLa	445..471	CDD:197566
		MAM	484..639	CDD:459878
		EGF-like. /evidence=ECO:0000250|UniProtKB:Q9UM73	991..1029
		FXa_inhibition	991..1025	CDD:464251
		PTKc_ALK_LTK	1113..1389	CDD:270632
		PHA03247	<1374..1580	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1412..1556