DRSC/TRiP Functional Genomics Resources

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Protein Alignment POTEH and ACT1

DIOPT Version :9

Sequence 1:NP_001129685.1 Gene:POTEH / 23784 HGNCID:133 Length:545 Species:Homo sapiens
Sequence 2:NP_116614.1 Gene:ACT1 / 850504 SGDID:S000001855 Length:375 Species:Saccharomyces cerevisiae


Alignment Length:331 Identity:67/331 - (20%)
Similarity:124/331 - (37%) Gaps:89/331 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   222 NSEVVKLLLDR---RCQLNIL-DNKKRTALTKAV---------------------QCQEDECALM 261
            :|||..|::|.   .|:.... |:..|......|                     :.|.....|.
Yeast     2 DSEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGIMVGMGQKDSYVGDEAQSKRGILT 66

Human   262 L---LEHGTDPNIPDEYGNTALHYAIYNEDKLMAK--ALLLYGADIESK-NKHGLTPLLLGVHEQ 320
            |   :|||...|..|.  ....|:..|||.::..:  .:||..|.:..| |:..:|.::.    :
Yeast    67 LRYPIEHGIVTNWDDM--EKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMTQIMF----E 125

Human   321 KQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSL---------LLEQNIDVSSQDLSGQ 376
            ...|..|.:..:|.|:.......|.::|....|...:|.:         :|  .||::.:||:..
Yeast   126 TFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAIL--RIDLAGRDLTDY 188

Human   377 -----TAREYAVSSRHNVICQLLSDYKEK---------QILKVSSENSNPEQDLKLTSEEESQRL 427
                 :.|.|:.|:  ....:::.|.|||         |.::.::::|:.|:..:|   .:.|.:
Yeast   189 LMKILSERGYSFST--TAEREIVRDIKEKLCYVALDFEQEMQTAAQSSSIEKSYEL---PDGQVI 248

Human   428 K-GSENSQPEEMSQEPEI----NKGGDR-------KVEEEMKKH--------GSTHM--GFPENL 470
            . |:|..:..|....|.:    :.|.|:       |.:.:::|.        |.|.|  |..|.:
Yeast   249 TIGNERFRAPEALFHPSVLGLESAGIDQTTYNSIMKCDVDVRKELYGNIVMSGGTTMFPGIAERM 313

Human   471 TNGATA 476
            ....||
Yeast   314 QKEITA 319

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
POTEHNP_001129685.1 Ank_4 180..230 CDD:290365 4/7 (57%)
ANK 1 180..208
ANK 204..329 CDD:238125 29/137 (21%)
ANK 2 209..238 6/18 (33%)
ANK repeat 211..240 CDD:293786 6/21 (29%)
Ank_2 214..306 CDD:289560 25/114 (22%)
ANK repeat 242..273 CDD:293786 9/54 (17%)
ANK 3 242..271 8/52 (15%)
ANK 270..394 CDD:238125 28/140 (20%)
ANK repeat 275..306 CDD:293786 8/33 (24%)
ANK 4 275..304 7/30 (23%)
Ank_2 280..372 CDD:289560 21/103 (20%)
ANK repeat 308..339 CDD:293786 5/30 (17%)
ANK 5 308..337 5/28 (18%)
ANK repeat 341..372 CDD:293786 7/39 (18%)
ANK 6 341..370 7/37 (19%)
ANK 7 374..404 8/43 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 406..524 19/93 (20%)
ACT1NP_116614.1 NBD_sugar-kinase_HSP70_actin 1..375 CDD:418402 67/331 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5277
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100127
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.710

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