DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FLRT1 and Lrt

DIOPT Version :9

Sequence 1:	NP_001371395.1	Gene:	FLRT1 / 23769	HGNCID:	3760	Length:	674	Species:	Homo sapiens
Sequence 2:	NP_001286640.1	Gene:	Lrt / 37342	FlyBaseID:	FBgn0034540	Length:	830	Species:	Drosophila melanogaster

Alignment Length:	637	Identity:	133/637 - (20%)
Similarity:	232/637 - (36%)	Gaps:	181/637 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    71 GLTSIPADIPDDATTLYLQNNQINNAGIPQDLKTKVN---VQVIYLYENDLDEFPINLPR----- 127
            ||||:        ..|.|.||||::  |.|  :|.||   ::|:.|..|.|.::..:|..
  Fly   269 GLTSL--------VYLELSNNQISS--ISQ--RTFVNLRKLEVLKLGGNRLGDYAQSLRSLSQCL 321

Human   128 SLRELHLQDNNVR-TIARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSS 191
            |||:|.||.||:. .::..:|..:..||.|:|:.|.:.  ||:..|.|:..  :|:.||..|
  Fly   322 SLRQLDLQANNLNGPLSEQTLPGMRNLESLNLNRNLIK--SIQNKALANFS--RLVSLSLRH--- 379

Human   192 IPSGLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLV 256
                            |:|..:..|||.||.:|..|.|..|.:.  .|:..:...|..||.|.|.
  Fly   380 ----------------NQIDVLQDHAFFGLGALDSLDLSYNGIV--AISSASLQHLSRLTVLDLT 426

Human   257 RNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLA 321
            .|.|.|              |..:.|:.:|     .:|||.   |:.|:::.:.|...|....|.
  Fly   427 HNFLRA--------------LTSDLIAPLP-----SLRELR---LAGNDISIVARNAMDGARELE 469

Human   322 QLLLRNNPWFCGCNLMWLRDWVKARAAVVNVRGLMCQGPEKVRGMAIKDITSEMDECFETGPQGG 386
            .|.::.||..|.|::....:|:: .:.:.:.....|..|.::.|..:..:..|...|.....:..
  Fly   470 SLQMQENPLSCDCSIRPFAEWLQ-ESQLHSSLSASCVTPPRLEGAPLLQVPVETLSCDMDNVEKD 533

Human   387 VANAAAKTTASNHASATTPQGSLFTLKAKRPGLRLPDSNIDYPMATGDGAKTLAIHVKALTAD-S 450
            .||...........:.|:|      :|                    |.::.:.:|....:.| .
  Fly   534 NANIMQHLETLAKPNQTSP------IK--------------------DLSEEIILHELHFSTDYG 572

Human   451 IRITWKATLPASSF-----------RLSWLRLGHSPAVGSITETLVQGDKTEYLL----TALEPK 500
            :.:||...|....:           .::.:.:.:||.  .....:|.|..|..::    ::||..
  Fly   573 LILTWLLNLSKKDYMCDAIFVYKEEHINEILIDNSPI--HCESKVVNGQNTVSVIVPDSSSLEIG 635

Human   501 STYIICMVTMETSNAYVADETPVCAKAETADSYGPTTTLNQEQNAGPMASLPLAGIIGGAVALVF 565
            .:|..|:|.::       ::.|                 :.|.|.|......|.....|||.:
  Fly   636 ESYRFCLVMIQ-------EQKP-----------------DSELNIGCSNITRLERSSPGAVPV-- 674

Human   566 LFLVLGAICWYVHQAGELLTRERAYNRGSRKKDDYMESG------TKKDNSILEIRGPGLQMLPI 624
                           .....|...||....|.:...::|      .::.||::     |.|
  Fly   675 ---------------SRQYQRRPYYNANELKPEVVHDAGEDYQVNQRRFNSVV-----GSQ---- 715

Human   625 NPYRAKEEYVVH--TIFPSNGSS---------LCKATHTIGYGTTRGYRDGG 665
             |.:.::..::|  |:..|...|         |..:...:.:|.||..:.||
  Fly   716 -PQQTQQSTLLHSYTVIDSLNKSFLPGLGLGVLVTSVLVLIWGATRIRQTGG 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FLRT1	NP_001371395.1	PRK15370	<58..>329	CDD:185268	74/266 (28%)
		leucine-rich repeat	108..128	CDD:275380	5/24 (21%)
		leucine-rich repeat	129..152	CDD:275380	8/23 (35%)
		leucine-rich repeat	153..178	CDD:275380	9/24 (38%)
		leucine-rich repeat	179..199	CDD:275380	4/19 (21%)
		leucine-rich repeat	200..223	CDD:275380	7/22 (32%)
		leucine-rich repeat	224..249	CDD:275380	6/24 (25%)
		leucine-rich repeat	250..271	CDD:275380	7/20 (35%)
		leucine-rich repeat	272..295	CDD:275380	3/22 (14%)
		leucine-rich repeat	296..319	CDD:275380	5/22 (23%)
		PCC	300..>406	CDD:188093	19/105 (18%)
		FN3	441..505	CDD:214495	13/79 (16%)
Lrt	NP_001286640.1	LRR_RI	<151..334	CDD:238064	28/76 (37%)
		leucine-rich repeat	179..199	CDD:275378
		leucine-rich repeat	200..223	CDD:275380
		leucine-rich repeat	225..248	CDD:275380
		LRR_8	249..307	CDD:290566	18/49 (37%)
		leucine-rich repeat	249..272	CDD:275380	2/2 (100%)
		LRR_RI	<270..479	CDD:238064	75/267 (28%)
		leucine-rich repeat	273..296	CDD:275380	11/34 (32%)
		leucine-rich repeat	297..322	CDD:275380	5/24 (21%)
		LRR_8	322..382	CDD:290566	23/82 (28%)
		leucine-rich repeat	323..347	CDD:275380	8/23 (35%)
		leucine-rich repeat	348..371	CDD:275380	9/26 (35%)
		LRR_8	370..428	CDD:290566	21/80 (26%)
		leucine-rich repeat	372..395	CDD:275380	11/41 (27%)
		leucine-rich repeat	396..419	CDD:275380	6/24 (25%)
		LRR_8	418..478	CDD:290566	20/81 (25%)
		leucine-rich repeat	420..443	CDD:275380	10/41 (24%)
		leucine-rich repeat	444..467	CDD:275380	7/25 (28%)
		LRRCT	476..526	CDD:214507	9/50 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870