DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FLRT3 and Lrt

DIOPT Version :9

Sequence 1:	NP_037413.1	Gene:	FLRT3 / 23767	HGNCID:	3762	Length:	649	Species:	Homo sapiens
Sequence 2:	NP_001286640.1	Gene:	Lrt / 37342	FlyBaseID:	FBgn0034540	Length:	830	Species:	Drosophila melanogaster

Alignment Length:	619	Identity:	132/619 - (21%)
Similarity:	232/619 - (37%)	Gaps:	158/619 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    20 QVAPL------SVMAKSCPSV---------CRCDA-----------GFIYCNDRFLTSIPTGIPE 58
            ||:.|      ::|...||::         |.||.           |.:...||..|| |..|.
  Fly   115 QVSSLPLPVDDALMEWKCPNITGTRNAELECGCDLPHTLRCNIDLHGMMLLADRLRTS-PYSIS- 177

Human    59 DATTLYLQNNQINNAGIPSDLK--------NLL----KVERIY---------------LYHNSLD 96
                  |.:..:.|....||.|        .|:    :::|::               |..|:|.
  Fly   178 ------LLDCSLRNVTFLSDAKIFDNVSLHGLVISSGEIKRVHKSAFLGIRGPLQALGLPGNALM 236

Human    97 EFPTN---LPKYVKELHLQENNIR---TITYDSLSKIPYLEELHLDDNSVSAVS----------- 144
            ..|.|   ....::.|.|..|.|:   |..:..|:.:.|||   |.:|.:|::|
  Fly   237 SVPWNALSTLSALERLDLANNKIKALGTADFVGLTSLVYLE---LSNNQISSISQRTFVNLRKLE 298

Human   145 -IEEGAFRDSNY------------LRLLFLSRNHLS------TIPWGLPRTIEELRLDDNRISTI 190
             ::.|..|..:|            ||.|.|..|:|:      |:| |: |.:|.|.|:.|.|.:|
  Fly   299 VLKLGGNRLGDYAQSLRSLSQCLSLRQLDLQANNLNGPLSEQTLP-GM-RNLESLNLNRNLIKSI 361

Human   191 SSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTA-APVNLPG-TNLRKLY 253
            .:.:|...:.|..|.|..|.::  .|.|..||.|..|..|.|..|.:.| :..:|.. :.|..|.
  Fly   362 QNKALANFSRLVSLSLRHNQID--VLQDHAFFGLGALDSLDLSYNGIVAISSASLQHLSRLTVLD 424

Human   254 LQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRD 318
            |..|.:..:..:..:.|..|..|.::.|::|.:.:...|....:..|.::.||..|.|.::...:
  Fly   425 LTHNFLRALTSDLIAPLPSLRELRLAGNDISIVARNAMDGARELESLQMQENPLSCDCSIRPFAE 489

Human   319 WLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDC------KDSGIVSTIQITTAIPNTVYPA 377
            |||...:..:: ...|..|.::.|..:..:..|...|      ||:..:.....|.|.||...|.
  Fly   490 WLQESQLHSSL-SASCVTPPRLEGAPLLQVPVETLSCDMDNVEKDNANIMQHLETLAKPNQTSPI 553

Human   378 QGQWPAPVTKQPDIKNPKLTKD-HQTT--GSPSRKTITITVKSVTSDTIHISWKLALPMTALRLS 439
            :           |:....:..: |.:|  |......:.::.|....|.|.:       .....::
  Fly   554 K-----------DLSEEIILHELHFSTDYGLILTWLLNLSKKDYMCDAIFV-------YKEEHIN 600

Human   440 WLKLGHSPAFGSITETIVTGERSEYLVTALEPDS-------PYKVCMVPMETSNLYLFDETP--- 494
            .:.:.:||.  .....:|.|:.:   |:.:.|||       .|:.|:|.::       ::.|
  Fly   601 EILIDNSPI--HCESKVVNGQNT---VSVIVPDSSSLEIGESYRFCLVMIQ-------EQKPDSE 653

Human   495 --VCIETETAPLRMYNPTTTLNREQEKEPYKNPN 526
              :.....|...|.......::|:.::.||.|.|
  Fly   654 LNIGCSNITRLERSSPGAVPVSRQYQRRPYYNAN 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FLRT3	NP_037413.1	LRRNT	31..61	CDD:214470	12/49 (24%)
		Interaction with ADGRL3. /evidence=ECO:0000269\|PubMed:26235030	38..67		9/39 (23%)
		LRR 1. /evidence=ECO:0000255	59..80		4/20 (20%)
		leucine-rich repeat	61..84	CDD:275378	6/34 (18%)
		LRR 2. /evidence=ECO:0000255	84..104		6/37 (16%)
		leucine-rich repeat	85..104	CDD:275380	6/36 (17%)
		LRR 3. /evidence=ECO:0000255	105..126		6/23 (26%)
		LRR_8	106..166	CDD:290566	21/86 (24%)
		leucine-rich repeat	106..129	CDD:275380	6/25 (24%)
		LRR_RI	<120..259	CDD:238064	47/170 (28%)
		LRR 4. /evidence=ECO:0000255	129..150		8/32 (25%)
		leucine-rich repeat	130..155	CDD:275380	8/36 (22%)
		LRR 5. /evidence=ECO:0000255	155..175		10/37 (27%)
		leucine-rich repeat	156..176	CDD:275380	9/25 (36%)
		LRR_8	175..237	CDD:290566	21/61 (34%)
		LRR 6. /evidence=ECO:0000255	176..197		7/20 (35%)
		leucine-rich repeat	177..200	CDD:275380	7/22 (32%)
		LRR 7. /evidence=ECO:0000255	200..220		6/19 (32%)
		leucine-rich repeat	201..226	CDD:275380	9/24 (38%)
		LRR 8. /evidence=ECO:0000255	226..247		6/22 (27%)
		leucine-rich repeat	227..248	CDD:275380	6/22 (27%)
		LRR_8	247..306	CDD:290566	11/58 (19%)
		LRR_4	247..287	CDD:289563	9/39 (23%)
		LRR 9. /evidence=ECO:0000255	248..269		4/20 (20%)
		leucine-rich repeat	249..272	CDD:275380	5/22 (23%)
		LRR 10. /evidence=ECO:0000255	272..293		4/20 (20%)
		leucine-rich repeat	273..296	CDD:275380	5/22 (23%)
		LRRCT	305..356	CDD:214507	12/56 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..407		4/22 (18%)
		fn3	413..478	CDD:278470	12/71 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..649
Lrt	NP_001286640.1	LRR_RI	<151..334	CDD:238064	40/193 (21%)
		leucine-rich repeat	179..199	CDD:275378	4/19 (21%)
		leucine-rich repeat	200..223	CDD:275380	2/22 (9%)
		leucine-rich repeat	225..248	CDD:275380	5/22 (23%)
		LRR_8	249..307	CDD:290566	14/60 (23%)
		leucine-rich repeat	249..272	CDD:275380	6/22 (27%)
		LRR_RI	<270..479	CDD:238064	56/215 (26%)
		leucine-rich repeat	273..296	CDD:275380	7/25 (28%)
		leucine-rich repeat	297..322	CDD:275380	3/24 (13%)
		LRR_8	322..382	CDD:290566	21/61 (34%)
		leucine-rich repeat	323..347	CDD:275380	9/25 (36%)
		leucine-rich repeat	348..371	CDD:275380	7/22 (32%)
		LRR_8	370..428	CDD:290566	18/59 (31%)
		leucine-rich repeat	372..395	CDD:275380	9/24 (38%)
		leucine-rich repeat	396..419	CDD:275380	6/22 (27%)
		LRR_8	418..478	CDD:290566	12/59 (20%)
		leucine-rich repeat	420..443	CDD:275380	5/22 (23%)
		leucine-rich repeat	444..467	CDD:275380	5/22 (23%)
		LRRCT	476..526	CDD:214507	11/50 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	1	0.960