DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment OSBP2 and OSH2

DIOPT Version :10

Sequence 1:NP_110385.1 Gene:OSBP2 / 23762 HGNCID:8504 Length:916 Species:Homo sapiens
Sequence 2:NP_010265.1 Gene:OSH2 / 851543 SGDID:S000002177 Length:1283 Species:Saccharomyces cerevisiae


Alignment Length:1140 Identity:284/1140 - (24%)
Similarity:446/1140 - (39%) Gaps:363/1140 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    81 EPVSETTSEPEPGAGQPSELLQG-SRPGSESSSGVGAGPFTKAASEPLSRAVGSATFLRPESGSL 144
            :|.:.||...|....:..|:.|. .:.|:|::...|.|      ..||..........:|.:...
Yeast   203 DPETGTTLLYEYSQKKDIEMCQWLLKHGAEATVKDGKG------RSPLDLVKNIKLPAKPSNNVT 261

Human   145 PALKPLPLLRPGQAKTPLGVPMSGTGTTSSAPLALLPLDSFEGWLLKWTNYLKGYQRRWFVL-GN 208
            |.:|...||.....:..:    ......||.|      .:::|:|.||||:..||:.|||:| |:
Yeast   262 PEIKLKNLLEKNLREQAI----VHEDVASSKP------PTYKGFLKKWTNFAHGYKLRWFILSGD 316

Human   209 GLLSYYRNQGEMAHTCRGTINLSTA--HIDTEDSCGILL---TSGARSYHLKASSEVDRQQWITA 268
            |.||||::|..:... |||:.:||.  |||:.:.....|   .:|...:.||.:..::..:|:.|
Yeast   317 GNLSYYKDQSHVDRP-RGTLKVSTCRLHIDSSEKLNFELLGGITGTTRWRLKGNHPIETTRWVNA 380

Human   269 LE-----------LAKAKAV----------RVMNTHSDDSGDDDEAT------------TPADKS 300
            ::           |.|.|||          ..:.:||...|...||:            .|:..|
Yeast   381 IQSAIRFAKDKEILNKKKAVPPSLALKNKSPALISHSKTQGSLPEASQYYQHTLHKEVIQPSSVS 445

Human   301 ELHHTLKNLSLKLDDLSTCNDLIAKHGAALQRSLTE--LDGLKIP-------------------- 343
            .......|||:...::. .||.:.:.|......:.|  |||.|.|                    
Yeast   446 LYRRPSNNLSVVSSEIQ-LNDNLTESGKRFVSKMIENRLDGSKTPVGVHTGSALQRVRSSNTLKS 509

Human   344 -----SESG-------------------------------------------------------- 347
                 |.||                                                        
Yeast   510 NRSMQSGSGVASPIDKVPNGANLSQSNTTTGSTASLSDNNYIDNFEGDEANSDDEEEDLGINFDR 574

Human   348 -------------EKLKVVNERATLFRITS-------------------NAMINACRDFLELAEI 380
                         |||.:. |:|....::|                   .::||....|.:|.::
Yeast   575 DEEYIKAQYGPYKEKLDMY-EQAISIELSSLIELIEQEEPSPEVWLTIKKSLINTSTIFGKLKDL 638

Human   381 HSRKWQRA--------------LQYEQEQRVHLEETIEQLA---KQHNSLERAFHSAPGRPANPS 428
            ..::.:|.              :|..:|..:.|....|:||   |:...|::..|          
Yeast   639 TYKRDKRLVDMVSKQGDVNNVWVQSVKELEMELSNKTERLASIDKERRGLKKILH---------- 693

Human   429 KSFIEG--------SLLTPKGEDS------------------EEDEDT---EYFDAMEDSTSFIT 464
            |..:|.        ||...|.::|                  ||||.:   |::||.| ....:|
Yeast   694 KKLLESHATAGNKESLENDKEQESDTTASTLGQIAKFISATKEEDEASDADEFYDAAE-LVDEVT 757

Human   465 VITEA----------------------------KEDSRKAEGSTGTSSVDWSSADNVL------- 494
            .:|||                            :::..|.|.:...:|..:...:|::       
Yeast   758 ELTEAHPEISTAAAPKHAPPPVPNETDNDSQYVQDEKSKIESNVEKTSQKFEKQNNLVTEDEPKT 822

Human   495 ----------DGAS--------------------------------LVPKGS-----SKVKRRVR 512
                      |..|                                |:.:||     ..:::|:.
Yeast   823 DQSLKNFKAEDKESQVKEKTKEIASSVIGEKTIVAVTTVQKRKEEYLLKEGSYLGYEDGIRKRLS 887

Human   513 IPNKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVHCTSSVEQM 577
            :.......::||:::|:.:|::::|:.:||.||||.|:|||:.|||||..|||:|.....|..:.
Yeast   888 MDKDDRPKISLWAVLKSMVGKDMTRMTLPVTFNEPTSLLQRVAEDLEYSELLDQAATFEDSTLRT 952

Human   578 CLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWS 642
            ..||||:.|||::|..|:||||||:||||||..| .|...|...||||||||.:|.:..|.. |.
Yeast   953 LYVAAFTASSYASTTKRVAKPFNPLLGETFEYSR-PDKQYRFFTEQVSHHPPISATWTESPR-WD 1015

Human   643 LWQEITISSKFRGKYISIMPLGAIHLEFQASGNH----YVWRKSTSTVHNIIVGKLWIDQSGDIE 703
            .|.|..:.:||.|:..::..||..|::.:.:.|.    |.|:|..:||..|::|...:|..|::.
Yeast  1016 FWGESFVDTKFNGRSFNVKHLGLWHIKLRPNDNEKEELYTWKKPNNTVIGILIGNPQVDNHGEVN 1080

Human   704 IVNHKTNDRCQLKFLPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKVMH------- 761
            :|||.|.|.|:|.|....:.| ..|.::||.|.:.:.:..::|.|.|:|.:...||:.       
Yeast  1081 VVNHTTGDHCKLYFKARGWRS-SGAYEITGEVYNKKKQKVWILGGHWNEAIFAKKVVKDGDLSLE 1144

Human   762 ------SSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMYYFSELALTLNEHE----EGVA 816
                  |:.:.|:.||         :..|:||....||...|:..|   |:|||..:    ..:.
Yeast  1145 KTRTAASAGNGPTDDG---------TKFLIWKANDRPEEPFNLTPF---AITLNAPQPHLLPWLP 1197

Human   817 PTDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRLEACGPGSSCSSEEEKEADAYTPLWF 881
            |||:|||||||.||.||:|||..||.|:|||||.:||:|             ||...: |.|.||
Yeast  1198 PTDTRLRPDQRAMEDGRYDEAGDEKFRVEEKQRAARRKR-------------EENNLE-YHPQWF 1248

Human   882 EKRLDPLTGEMACVYKGGYWEAKEKQDWHMCPNIF 916
            .:...|:|......|.|.||..:...|...|.:||
Yeast  1249 VRDTHPITKAKYWRYTGKYWVKRRDHDLKDCGDIF 1283

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OSBP2NP_110385.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 34..121 10/40 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 139..163 5/23 (22%)
PH_OSBP_ORP4 185..280 CDD:270101 38/121 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..301 6/30 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 417..448 9/56 (16%)
Oxysterol_BP 522..905 CDD:460126 152/403 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 813..842 18/28 (64%)
OSH2NP_010265.1 Ank_4 59..127 CDD:372654
ANK repeat 60..104 CDD:293786
ANKYR <99..>246 CDD:440430 12/48 (25%)
ANK repeat 106..137 CDD:293786
PH_Osh1p_Osh2p_yeast 289..391 CDD:241446 34/108 (31%)
Oxysterol_BP 897..1271 CDD:460126 152/402 (38%)
Blue background indicates that the domain is not in the aligned region.

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