DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment OSBP2 and OSH2

DIOPT Version :9

Sequence 1:	NP_110385.1	Gene:	OSBP2 / 23762	HGNCID:	8504	Length:	916	Species:	Homo sapiens
Sequence 2:	NP_010265.1	Gene:	OSH2 / 851543	SGDID:	S000002177	Length:	1283	Species:	Saccharomyces cerevisiae

Alignment Length:	1140	Identity:	284/1140 - (24%)
Similarity:	446/1140 - (39%)	Gaps:	363/1140 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    81 EPVSETTSEPEPGAGQPSELLQG-SRPGSESSSGVGAGPFTKAASEPLSRAVGSATFLRPESGSL 144
            :|.:.||...|....:..|:.|. .:.|:|::...|.|      ..||..........:|.:...
Yeast   203 DPETGTTLLYEYSQKKDIEMCQWLLKHGAEATVKDGKG------RSPLDLVKNIKLPAKPSNNVT 261

Human   145 PALKPLPLLRPGQAKTPLGVPMSGTGTTSSAPLALLPLDSFEGWLLKWTNYLKGYQRRWFVL-GN 208
            |.:|...||.....:..:    ......||.|      .:::|:|.||||:..||:.|||:| |:
Yeast   262 PEIKLKNLLEKNLREQAI----VHEDVASSKP------PTYKGFLKKWTNFAHGYKLRWFILSGD 316

Human   209 GLLSYYRNQGEMAHTCRGTINLSTA--HIDTEDSCGILL---TSGARSYHLKASSEVDRQQWITA 268
            |.||||::|..:... |||:.:||.  |||:.:.....|   .:|...:.||.:..::..:|:.|
Yeast   317 GNLSYYKDQSHVDRP-RGTLKVSTCRLHIDSSEKLNFELLGGITGTTRWRLKGNHPIETTRWVNA 380

Human   269 LE-----------LAKAKAV----------RVMNTHSDDSGDDDEAT------------TPADKS 300
            ::           |.|.|||          ..:.:||...|...||:            .|:..|
Yeast   381 IQSAIRFAKDKEILNKKKAVPPSLALKNKSPALISHSKTQGSLPEASQYYQHTLHKEVIQPSSVS 445

Human   301 ELHHTLKNLSLKLDDLSTCNDLIAKHGAALQRSLTE--LDGLKIP-------------------- 343
            .......|||:...::. .||.:.:.|......:.|  |||.|.|
Yeast   446 LYRRPSNNLSVVSSEIQ-LNDNLTESGKRFVSKMIENRLDGSKTPVGVHTGSALQRVRSSNTLKS 509

Human   344 -----SESG-------------------------------------------------------- 347
                 |.||
Yeast   510 NRSMQSGSGVASPIDKVPNGANLSQSNTTTGSTASLSDNNYIDNFEGDEANSDDEEEDLGINFDR 574

Human   348 -------------EKLKVVNERATLFRITS-------------------NAMINACRDFLELAEI 380
                         |||.:. |:|....::|                   .::||....|.:|.::
Yeast   575 DEEYIKAQYGPYKEKLDMY-EQAISIELSSLIELIEQEEPSPEVWLTIKKSLINTSTIFGKLKDL 638

Human   381 HSRKWQRA--------------LQYEQEQRVHLEETIEQLA---KQHNSLERAFHSAPGRPANPS 428
            ..::.:|.              :|..:|..:.|....|:||   |:...|::..|
Yeast   639 TYKRDKRLVDMVSKQGDVNNVWVQSVKELEMELSNKTERLASIDKERRGLKKILH---------- 693

Human   429 KSFIEG--------SLLTPKGEDS------------------EEDEDT---EYFDAMEDSTSFIT 464
            |..:|.        ||...|.::|                  ||||.:   |::||.| ....:|
Yeast   694 KKLLESHATAGNKESLENDKEQESDTTASTLGQIAKFISATKEEDEASDADEFYDAAE-LVDEVT 757

Human   465 VITEA----------------------------KEDSRKAEGSTGTSSVDWSSADNVL------- 494
            .:|||                            :::..|.|.:...:|..:...:|::
Yeast   758 ELTEAHPEISTAAAPKHAPPPVPNETDNDSQYVQDEKSKIESNVEKTSQKFEKQNNLVTEDEPKT 822

Human   495 ----------DGAS--------------------------------LVPKGS-----SKVKRRVR 512
                      |..|                                |:.:||     ..:::|:.
Yeast   823 DQSLKNFKAEDKESQVKEKTKEIASSVIGEKTIVAVTTVQKRKEEYLLKEGSYLGYEDGIRKRLS 887

Human   513 IPNKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVHCTSSVEQM 577
            :.......::||:::|:.:|::::|:.:||.||||.|:|||:.|||||..|||:|.....|..:.
Yeast   888 MDKDDRPKISLWAVLKSMVGKDMTRMTLPVTFNEPTSLLQRVAEDLEYSELLDQAATFEDSTLRT 952

Human   578 CLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWS 642
            ..||||:.|||::|..|:||||||:||||||..| .|...|...||||||||.:|.:..|.. |.
Yeast   953 LYVAAFTASSYASTTKRVAKPFNPLLGETFEYSR-PDKQYRFFTEQVSHHPPISATWTESPR-WD 1015

Human   643 LWQEITISSKFRGKYISIMPLGAIHLEFQASGNH----YVWRKSTSTVHNIIVGKLWIDQSGDIE 703
            .|.|..:.:||.|:..::..||..|::.:.:.|.    |.|:|..:||..|::|...:|..|::.
Yeast  1016 FWGESFVDTKFNGRSFNVKHLGLWHIKLRPNDNEKEELYTWKKPNNTVIGILIGNPQVDNHGEVN 1080

Human   704 IVNHKTNDRCQLKFLPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKVMH------- 761
            :|||.|.|.|:|.|....:.| ..|.::||.|.:.:.:..::|.|.|:|.:...||:.
Yeast  1081 VVNHTTGDHCKLYFKARGWRS-SGAYEITGEVYNKKKQKVWILGGHWNEAIFAKKVVKDGDLSLE 1144

Human   762 ------SSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMYYFSELALTLNEHE----EGVA 816
                  |:.:.|:.||         :..|:||....||...|:..|   |:|||..:    ..:.
Yeast  1145 KTRTAASAGNGPTDDG---------TKFLIWKANDRPEEPFNLTPF---AITLNAPQPHLLPWLP 1197

Human   817 PTDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRLEACGPGSSCSSEEEKEADAYTPLWF 881
            |||:|||||||.||.||:|||..||.|:|||||.:||:|             ||...: |.|.||
Yeast  1198 PTDTRLRPDQRAMEDGRYDEAGDEKFRVEEKQRAARRKR-------------EENNLE-YHPQWF 1248

Human   882 EKRLDPLTGEMACVYKGGYWEAKEKQDWHMCPNIF 916
            .:...|:|......|.|.||..:...|...|.:||
Yeast  1249 VRDTHPITKAKYWRYTGKYWVKRRDHDLKDCGDIF 1283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OSBP2	NP_110385.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..121		10/40 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..163		5/23 (22%)
		PH_OSBP_ORP4	185..280	CDD:270101	38/121 (31%)
		PH	186..274	CDD:278594	34/104 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..301		6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	417..448		9/56 (16%)
		Oxysterol_BP	522..896	CDD:279564	148/394 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	813..842		18/28 (64%)
OSH2	NP_010265.1	ANKYR	<47..194	CDD:223738
		ANK repeat	60..104	CDD:293786
		ANK repeat	106..137	CDD:293786
		Ank_5	191..247	CDD:404699	12/49 (24%)
		PH_Osh1p_Osh2p_yeast	289..391	CDD:241446	34/108 (31%)
		Oxysterol_BP	897..1268	CDD:395990	150/399 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	272	1.000	Domainoid score	I313
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	368	1.000	Inparanoid score	I421
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm10107
orthoMCL	1	0.900	-	-		OOG6_101373
Panther	1	1.100	-	-	O	PTHR10972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3013
SonicParanoid	1	1.000	-	-		X203
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.850