DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PITPNB and rdgB

DIOPT Version :9

Sequence 1:	XP_011528354.1	Gene:	PITPNB / 23760	HGNCID:	9002	Length:	274	Species:	Homo sapiens
Sequence 2:	NP_001259535.1	Gene:	rdgB / 32340	FlyBaseID:	FBgn0003218	Length:	1297	Species:	Drosophila melanogaster

Alignment Length:	283	Identity:	106/283 - (37%)
Similarity:	167/283 - (59%)	Gaps:	16/283 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     4 LLMEKCRVVLPCSVQEYQVGQLYSVAEASKNET-GGGEGIEVLKNEPYEKDGE--KGQYTHKIYH 65
            :|:::.|:.||.:|:||::.|||.:|:.|:.|: |.|.|:|::.|||| |||.  .||||.||||
  Fly     1 MLIKEYRIPLPLTVEEYRIAQLYMIAKKSREESHGEGSGVEIIINEPY-KDGPGGNGQYTKKIYH 64

Human    66 LKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGL 130
            :.:.:|.:::.:.|:.:|...|:|||||||.||..|..:: :.|.:.|||::.||.|..:||..|
  Fly    65 VGNHLPGWIKSLLPKSALTVEEEAWNAYPYTRTRYTCPFV-EKFSLDIETYYYPDNGYQDNVFQL 128

Human   131 DPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFQSVKTKRGPLGPNWKKEL-----ANSPDCP 190
            ..:..:...:..|||. :.|:...||..:|||..|.|.||.||||..:|.:|.     ......|
  Fly   129 SGSDLRNRIVDVIDIV-KDQLWGGDYVKEEDPKHFVSDKTGRGPLAEDWLEEYWREVKGKKQPTP 192

Human   191 Q----MCAYKLVTIKFKWWGLQSKVENFIQKQE-KRIFTNFHRQLFCWIDKWIDLTMEDIRRMED 250
            :    |.|||:..::|::||:|:|:|.||.... :::....|||.:.|.|:|..||:||||.:|.
  Fly   193 RNMSLMTAYKICRVEFRYWGMQTKLEKFIHDVALRKMMLRAHRQAWAWQDEWFGLTIEDIRELER 257

Human   251 ETQKELETLRNQGQVRGTSAASD 273
            :||..|......|:.....:.|:
  Fly   258 QTQLALAKKMGGGEECSDDSVSE 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PITPNB	XP_011528354.1	SRPBCC_PITPNA-B_like	10..261	CDD:176897	103/263 (39%)
rdgB	NP_001259535.1	SRPBCC_PITPNM1-2_like	1..268	CDD:176898	104/269 (39%)
		DDHD	746..924	CDD:280937
		LNS2	1072..1203	CDD:197870
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810