Protein Alignment PRKD3 and MPS1

DIOPT Version :9

• Sequence 1: NP_005804.1
• Gene: PRKD3 / 23683
• HGNCID: 9408
• Length: 890
• Species: Homo sapiens
• Sequence 2: NP_010256.2
• Gene: MPS1 / 851533
• SGDID: S000002186
• Length: 764
• Species: Saccharomyces cerevisiae
• Alignment Length: 759
• Identity: 168/759 - (22%)
• Similarity: 277/759 - (36%)
• Gaps: 226/759 - (29%)

Human   179 VRQGLKCEGCGLNYHKRCA--FKIPNNCS--GVRKRRLSNVSLPGPGLSVPR-PLQP----EYVA 234
            :||.:| |.....|.:|.:  |.|.|..:  |..||.::..::...  .||. |.||    |.|.
Yeast   136 LRQNMK-EDITAKYAERRSKRFLISNRTTKLGPAKRAMTLTNIFDE--DVPNSPNQPINARETVE 197

Human   235 LPSEESH-VHQEPSKRIPSWSG------RPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKR-- 290
            ||.|:|| .:.:.:||...:..      .||                           ||.|:
Yeast   198 LPLEDSHQTNFKETKRNTDYDSIDFGDLNPI---------------------------QYIKKHN 235

Human   291 -------LLKGLF--RQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDN 346
                   |:..::  :|..:.:......|   :|:       |:.:....||        ..:.:
Yeast   236 LPTSDLPLISQIYFDKQREENRQAALRKH---SSR-------ELLYKSRSSS--------SSLSS 282

Human   347 NDI--NSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVERD-EEAVKTISPSTSNNIPLMRVVQSIK 408
            |::  |.|:|...::..:|............|.:::.|. :|.:.| |.:::.|.|:.::.:.|.
Yeast   283 NNLLANKDNSITSNNGSQPRRKVSTGSSSSKSSIEIRRALKENIDT-SNNSNFNSPIHKIYKGIS 346

Human   409 HTKRKSSTM--VKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSP 471
            ..|...|..  |.....::....|||.::...||.........||
Yeast   347 RNKDSDSEKREVLRNISINANHADNLLQQENKRLKRSLDDAITNE-------------------- 391

Human   472 RDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTP 536
                ||:.          .:..|::         |.|.                    ...|||.
Yeast   392 ----NINS----------KNLEVFY---------HRPA--------------------PKPPVTK 413

Human   537 QASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTV--YQIFADEVLGSGQFGIVYGGKHRKTG 599
            :..: ..|.:         |.|:||     |.:|.||  .|....|:||.|....||  |.:.:|
Yeast   414 KVEI-VEPAK---------SASLSN-----NRNIITVNDSQYEKIELLGRGGSSRVY--KVKGSG 461

Human   600 RDV-AIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGD-MLEM 662
            ..| |:|.:....|........:.|:.:|:.|            :..:||..:::...|| :|.:
Yeast   462 NRVYALKRVSFDAFDDSSIDGFKGEIELLEKL------------KDQKRVIQLLDYEMGDGLLYL 514

Human   663 ILS----------SEKSRLP--ERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQ 715
            |:.          :::|.:|  ....:|...::|:.::.:|...|||.||||.|.:|...    .
Yeast   515 IMECGDHDLSQILNQRSGMPLDFNFVRFYTKEMLLCIKVVHDAGIVHSDLKPANFVLVKG----I 575

Human   716 VKLCDFGFARIIGEKS---FRRSVVGTPAYLAPEVLRSKGY---------------NRSLDMWSV 762
            :|:.|||.|..:.|.:   :|.:.:|||.|:|||.|.:..|               .|..||||.
Yeast   576 LKIIDFGIANAVPEHTVNIYRETQIGTPNYMAPEALVAMNYTQNSENQHEGNKWKVGRPSDMWSC 640

Human   763 GVIIYVSLSGTFPFNEDEDINDQIQNAAFMYP----PNPWREISGE-----AIDLINNLLQVKMR 818
            |.|||..:.|..|:...:..|..:   |.|.|    |.|....:.|     ||:|:...|.....
Yeast   641 GCIIYQMIYGKPPYGSFQGQNRLL---AIMNPDVKIPFPEHTSNNEKIPKSAIELMKACLYRNPD 702

Human   819 KRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYIT---HESDD 859
            ||::|||.||..:||.:.....:.|...|...||.:   |.|.|
Yeast   703 KRWTVDKVLSSTFLQPFMISGSIMEDLIRNAVRYGSEKPHISQD 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKD3	NP_005804.1	C1_PKD3_rpt1	145..219	CDD:410391	12/43 (28%)
		C1_PKD3_rpt2	267..335	CDD:410394	10/78 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	332..371		7/40 (18%)
		PH_PKD	410..534	CDD:269945	15/125 (12%)
		STKc_PKD	572..831	CDD:270984	83/301 (28%)
MPS1	NP_010256.2	PKc_Mps1	439..716	CDD:271033	81/297 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910