DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKD3 and SSK22

DIOPT Version :9

Sequence 1:	NP_005804.1	Gene:	PRKD3 / 23683	HGNCID:	9408	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_009998.2	Gene:	SSK22 / 850436	SGDID:	S000000669	Length:	1331	Species:	Saccharomyces cerevisiae

Alignment Length:	716	Identity:	154/716 - (21%)
Similarity:	252/716 - (35%)	Gaps:	242/716 - (33%)

- Green bases have known domain annotations that are detailed below.

Human   333 SLGTDTDIPMDIDNN-----------DINSDSSRGLDDTEEP----------------SPPEDKM 370
            |:|.|....:||.||           |:|...|:|.|....|                ...:.|.
Yeast   637 SIGCDLVPKLDIGNNLNVYDITTKETDLNILVSKGEDSKGIPYYRVVANSSSDLDRHAHQSKKKN 701

Human   371 FFLDPSD--LDVERDE--------------------EAV-----------------------KTI 390
            |..||.|  ||.:.:|                    |.|                       |..
Yeast   702 FSTDPFDQHLDEKNNEVFELEVALSSLGALVVLYPGEPVVWDGPVYKLPGNNLFASNEMDLGKIG 766

Human   391 SPST------SNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRK--RHYWRLDSKCLTL 447
            :|:|      .:|..|...:.....|...|.:.:::...:: :...:|:|  :.|::|....|..
Yeast   767 NPNTLILLNQGSNYALTYQIDKFNQTVGDSVSFIEKRCSLN-SIESSLQKINKAYYKLTYTVLNN 830

Human   448 FQNESGSKYYKEIPLSEILR------------------ISSPRD----FTNISQGSN------PH 484
            ::...|| :.|:.|.:|:|.                  .||.|.    |..:..|.|      ..
Yeast   831 YKGILGS-FMKQCPGNELLNSIFMFGRDFGRSFLKYNAFSSKRKYVIIFLMVKLGMNWLKFLVEE 894

Human   485 C-------FEIITDTMVYFVGENNGDS------------------------SHNPVLAATGVGLD 518
            |       |......|.:.:...:|.:                        ||..|:.|.
Yeast   895 CDPTDQRTFRWCVLAMDFAMQMTSGYNILALNVKQFQELKERVSVCMSLLISHFDVMGAR----- 954

Human   519 VAQSWEKAIRQALMPV------------------------TPQASVCTSPGQ-GK--DHKD---- 552
             |...|..::||.:.:                        |.:.::..:|.| ||  |..|
Yeast   955 -ATEAENGMQQARLNIDTEENIDEEATLEINSRLRLEAIKTLEKTMKRNPRQMGKVLDATDQGNK 1018

Human   553 --LSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVID------- 608
              ||.:.|:||        :|..:|  ....:|.|.||.||...:.:.|..:|:|.|.
Yeast  1019 YLLSLASSLSN--------VSMRWQ--KRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTM 1073

Human   609 KMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRL-P 672
            |..||.     ::.|:.:|:.|:||.||....:....::|.:.||...|..|..:|  :..|: .
Yeast  1074 KKIFPL-----IKEEMTVLEMLNHPNIVQYYGVEVHRDKVNIFMEYCEGGSLASLL--DHGRIED 1131

Human   673 ERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQ-VKLCDFGFAR-IIGEKSFRRS 735
            |.:|:....::|..|..||...:||.|:||||:||    .|.. :|..|||.|| ::|.::  |:
Yeast  1132 EMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILL----DFNGIIKYVDFGTARTVVGSRT--RT 1190

Human   736 V------------------VGTPAYLAPEVLRS---KGYNRSLDMWSVGVIIYVSLSGTFPF-NE 778
            |                  :|||.|:|||.:..   ||...:.|:|::|.::....:|..|: |.
Yeast  1191 VRNAAVQDFGVETKSLNEMMGTPMYMAPETISGSAVKGKLGADDVWALGCVVLEMATGRRPWSNL 1255

Human   779 DEDINDQIQNAAFMYPPNPWR-EISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLR 842
            |.:.......||...|..|.| |::......:...|......|.:..:.|..||:      :.:|
Yeast  1256 DNEWAIMYHVAAGRIPQLPNRDEMTAAGRAFLERCLVQDPTMRATAVELLIDPWM------IQIR 1314

Human   843 E 843
            |
Yeast  1315 E 1315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKD3	NP_005804.1	C1_PKD3_rpt1	145..219	CDD:410391
		C1_PKD3_rpt2	267..335	CDD:410394	1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..371		14/64 (22%)
		PH_PKD	410..534	CDD:269945	31/184 (17%)
		STKc_PKD	572..831	CDD:270984	78/291 (27%)
SSK22	NP_009998.2	STKc_MEKK4	1033..1309	CDD:270796	78/290 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910