DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKD3 and Prkd3

DIOPT Version :9

Sequence 1:	NP_005804.1	Gene:	PRKD3 / 23683	HGNCID:	9408	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_001164475.1	Gene:	Prkd3 / 75292	MGIID:	1922542	Length:	890	Species:	Mus musculus

Alignment Length:	890	Identity:	854/890 - (95%)
Similarity:	872/890 - (97%)	Gaps:	0/890 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSANNSPPSAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQ 65
            ||||||||||||||.|..:.|||||.|||||||||||||||||||||||||||||||||||||||
Mouse     1 MSANNSPPSAQKSVFPATVSAVLPAPSPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQ 65

Human    66 IGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADE 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 IGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADE 130

Human   131 IHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKR 195
            |||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||
Mouse   131 IHEGDLVEVVLSALATVEDFQIRPHALYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKR 195

Human   196 CAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWM 260
            ||||||||||||||||||||||||||||||||||||.|.|.|||||.||||||||||||||||||
Mouse   196 CAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPECVPLLSEESHTHQEPSKRIPSWSGRPIWM 260

Human   261 EKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEV 325
            |||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 EKMVMCRVKVPHTFAVHSYGRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEV 325

Human   326 TFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVERDEEAVKTI 390
            ||||||.|:|||.|:|||||::|:|||.||||||:|||||||||||||||:|||||||||.||||
Mouse   326 TFNGEPCSVGTDADMPMDIDSSDVNSDGSRGLDDSEEPSPPEDKMFFLDPTDLDVERDEETVKTI 390

Human   391 SPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSK 455
            ||||||||||||||||||||||:|||:||||||||||||||||||||||||||||||||||||||
Mouse   391 SPSTSNNIPLMRVVQSIKHTKRRSSTVVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSK 455

Human   456 YYKEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVA 520
            ||||||||||||:|||:|||:||||||||||||||||:|||||||||.|||||||||||||||||
Mouse   456 YYKEIPLSEILRVSSPQDFTSISQGSNPHCFEIITDTVVYFVGENNGSSSHNPVLAATGVGLDVA 520

Human   521 QSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSG 585
            |||||||||||||||||||||||||||||||||:|||||||||:|||||||:|||||||||||||
Mouse   521 QSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLATSISVSNCQVQENVDISSVYQIFADEVLGSG 585

Human   586 QFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFV 650
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   586 QFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFV 650

Human   651 VMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQ 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   651 VMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQ 715

Human   716 VKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDE 780
            ||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||
Mouse   716 VKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIVYVSLSGTFPFNEDE 780

Human   781 DINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFE 845
            ||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||
Mouse   781 DINDQIQNAAFMYPPNPWREISSEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFE 845

Human   846 TRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP 890
            ||||||||||||||||||||||||||.||||||||||||||||||
Mouse   846 TRIGERYITHESDDARWEIHAYTHNLEYPKHFIMAPNPDDMEEDP 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKD3	NP_005804.1	C1_PKD3_rpt1	145..219	CDD:410391	72/73 (99%)
		C1_PKD3_rpt2	267..335	CDD:410394	65/67 (97%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..371		29/38 (76%)
		PH_PKD	410..534	CDD:269945	116/123 (94%)
		STKc_PKD	572..831	CDD:270984	255/258 (99%)
Prkd3	NP_001164475.1	C1_1	155..204	CDD:278556	47/48 (98%)
		C1	272..321	CDD:237996	47/48 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..370		26/33 (79%)
		PH_PKD	410..534	CDD:269945	116/123 (94%)
		PH	417..531	CDD:278594	107/113 (95%)
		STKc_PKD	572..831	CDD:270984	255/258 (99%)
		S_TKc	580..832	CDD:214567	249/251 (99%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83972762
Domainoid	1	1.000	508	1.000	Domainoid score	I7425
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2055
Inparanoid	1	1.050	1752	1.000	Inparanoid score	I2177
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48438
OrthoDB	1	1.010	-	-		D182843at33208
OrthoFinder	1	1.000	-	-		FOG0002280
OrthoInspector	1	1.000	-	-		oto124619
orthoMCL	1	0.900	-	-		OOG6_103473
Panther	1	1.100	-	-	LDO	PTHR22968
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2489
SonicParanoid	1	1.000	-	-		X1509
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.440