DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKD3 and prkd3

DIOPT Version :9

Sequence 1:	NP_005804.1	Gene:	PRKD3 / 23683	HGNCID:	9408	Length:	890	Species:	Homo sapiens
Sequence 2:	XP_685483.4	Gene:	prkd3 / 557337	ZFINID:	ZDB-GENE-130530-880	Length:	891	Species:	Danio rerio

Alignment Length:	903	Identity:	733/903 - (81%)
Similarity:	797/903 - (88%)	Gaps:	25/903 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSANNSPP--------SAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSV 57
            |||:::.|        .:|....|       |..||..||...|..|||||:.|.||.|:   |:
Zfish     1 MSASSTSPLTLPNPFVHSQHQTAP-------PTPSPSPSPPVPLCVRLSNGNHSVPSPTS---SI 55

Human    58 HTVSFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENIL 122
            |.||||||||||||.||::..:||||:|||||||||.||||||||||:||||||||||:||:|||
Zfish    56 HGVSFLLQIGLTREMVTLDPHDLSLSSVKDLVCSIVDQKFPECGFFGLYDKILLFRHDLNSDNIL 120

Human   123 QLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEG 187
            |.:|||:|||||||:||||||.|||||||||||.|||||||||||||||||||||||||||||||
Zfish   121 QRLTSAEEIHEGDLIEVVLSAQATVEDFQIRPHALYVHSYKAPTFCDYCGEMLWGLVRQGLKCEG 185

Human   188 CGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPS 252
            |||||||||||||||||||||||||||||||||.||||||...|:.....||...||||.|||||
Zfish   186 CGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPSLSVPRPAPAEHATSSLEEQRPHQEPGKRIPS 250

Human   253 WSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKV 317
            ||||||||||||:.||||||||.:|:|||||||||||||||||||||||||||||||||||||||
Zfish   251 WSGRPIWMEKMVLGRVKVPHTFVIHTYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKV 315

Human   318 PRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVER 382
            |:||||  .|||||:|.|.|:|..|::|::|:||||.|||||:|||:.||||:||:|...:|.|:
Zfish   316 PKDCLG--VFNGEPASPGPDSDSTMEVDSSDVNSDSGRGLDDSEEPTTPEDKIFFMDSPFMDREK 378

Human   383 DEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTL 447
            |||.|||||||||.||||||||||:|||||:|||:|||||||||||:||||||||||||||||||
Zfish   379 DEEPVKTISPSTSTNIPLMRVVQSVKHTKRRSSTVVKEGWMVHYTSKDNLRKRHYWRLDSKCLTL 443

Human   448 FQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSS---HNPV 509
            |||:||:||||||||||||::...|||.:::.|.|||||||||.||||:||||.|...   |:|.
Zfish   444 FQNDSGAKYYKEIPLSEILQVEVARDFGSLALGGNPHCFEIITATMVYYVGENTGGPHLHIHSPA 508

Human   510 LAATGVGLDVAQSWEKAIRQALM--PVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDIST 572
            ||..||||:||||||:|||||||  |||||.||.|:.||.||||:||.||||||.|||||||||:
Zfish   509 LATGGVGLEVAQSWERAIRQALMPVPVTPQPSVGTAAGQSKDHKELSISISVSNSQIQENVDISS 573

Human   573 VYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVN 637
            :||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   574 IYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVN 638

Human   638 LECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKP 702
            ||||||||||||||||||||||||||||||||:||||||||:|||||||||:|||||||||||||
Zfish   639 LECMFETPERVFVVMEKLHGDMLEMILSSEKSKLPERITKFLVTQILVALRHLHFKNIVHCDLKP 703

Human   703 ENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIY 767
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   704 ENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIY 768

Human   768 VSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWL 832
            ||||||||||||||||||||||||||||.||::||.||.|||||||||||||||||||:||||||
Zfish   769 VSLSGTFPFNEDEDINDQIQNAAFMYPPTPWKDISAEATDLINNLLQVKMRKRYSVDKTLSHPWL 833

Human   833 QDYQTWLDLREFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP 890
            |||||||||||||||.|||||||||||||||.:||.|:|:||||||||||.|||:|||
Zfish   834 QDYQTWLDLREFETRRGERYITHESDDARWEKYAYEHSLMYPKHFIMAPNLDDMDEDP 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKD3	NP_005804.1	C1_PKD3_rpt1	145..219	CDD:410391	72/73 (99%)
		C1_PKD3_rpt2	267..335	CDD:410394	59/67 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..371		23/38 (61%)
		PH_PKD	410..534	CDD:269945	95/128 (74%)
		STKc_PKD	572..831	CDD:270984	247/258 (96%)
prkd3	XP_685483.4	C1_1	153..202	CDD:278556	47/48 (98%)
		C1	270..319	CDD:237996	44/48 (92%)
		PH_PKD	406..533	CDD:269945	95/126 (75%)
		STKc_PKD	573..832	CDD:270984	247/258 (96%)
		S_TKc	581..833	CDD:214567	242/251 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194343301
Domainoid	1	1.000	497	1.000	Domainoid score	I2811
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2055
Inparanoid	1	1.050	1495	1.000	Inparanoid score	I951
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48438
OrthoDB	1	1.010	-	-		D182843at33208
OrthoFinder	1	1.000	-	-		FOG0002280
OrthoInspector	1	1.000	-	-		oto41890
orthoMCL	1	0.900	-	-		OOG6_103473
Panther	1	1.100	-	-	LDO	PTHR22968
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2489
SonicParanoid	1	1.000	-	-		X1509
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	17	17.440