DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKD3 and PKD

DIOPT Version :9

Sequence 1:	NP_005804.1	Gene:	PRKD3 / 23683	HGNCID:	9408	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_001262705.1	Gene:	PKD / 42203	FlyBaseID:	FBgn0038603	Length:	906	Species:	Drosophila melanogaster

Alignment Length:	890	Identity:	453/890 - (50%)
Similarity:	568/890 - (63%)	Gaps:	150/890 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    60 VSFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQL 124
            |:||.|.|..|::|.:.|..|:|..:|||.|..:..|.|:.|...:.::||||.||.::.|:|.:
  Fly     6 VTFLFQFGSVRDAVCVPANSLTLKTLKDLACDFINTKIPDSGLTYLSERILLFVHDYSTPNVLHI 70

Human   125 ITSADEIHEGDLVEVVLSA----LATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKC 185
            |.||.|:.:..|||:||:|    ..|.|...::||:|.|||||.|||||:|||||:|||||||||
  Fly    71 INSAAEVVDETLVEIVLTASPILYPTSEMPTLKPHSLNVHSYKGPTFCDFCGEMLFGLVRQGLKC 135

Human   186 EGCGLNYHKRCAFKIPNNC---SGVRKRRLSNVSLP-GPGLSVPRPL-----------QPEYVAL 235
            :|||.||||||..||||||   :....||...:..| .|..|..:.|           ....:.:
  Fly   136 DGCGQNYHKRCVVKIPNNCNRSNDATSRRSFTLQAPRSPSGSSQQSLVSTEDSTGRNDSSSSLNI 200

Human   236 PSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGM 300
            |......|...|:     :|..:         :::||||.||:|..||:||.||:||||||:||:
  Fly   201 PGRHQRTHSSGSR-----NGLMV---------LRIPHTFMVHTYGIPTVCQLCKKLLKGLFKQGL 251

Human   301 QCKDCKFNCHKRCASKVPRDCLGEVTF-----------------------NGE------------ 330
            ||:||::|.||:|..|||.||.||...                       :|:
  Fly   252 QCRDCQYNTHKKCMDKVPHDCTGEAQLSQLQIQAGAKERDNFFREEFDDSDGDDGSEYGKYKSAM 316

Human   331 --------------PSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVE 381
                          |.:|....:.|.::.|..:..|||....:|.:.|           ||   .
  Fly   317 SSGVNLVAGRPREAPKALTNAHNSPPELVNGGLVDDSSVSGGETSKSS-----------SD---G 367

Human   382 RDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLT 446
            :.|::..:.|.|.|.||||||:|||:||||::....:||||:|||||.|...||:|||||||.:|
  Fly   368 QSEQSQSSTSSSPSANIPLMRIVQSVKHTKKRGGQALKEGWLVHYTSLDKAVKRYYWRLDSKTIT 432

Human   447 LFQNESGSKYYKEIPLSEILRISS----PRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHN 507
            ||.:|.||||:||:||:|:|.|.|    ||...|       :|||:....:.||||:       :
  Fly   433 LFVSEQGSKYHKELPLAELLSIESHLGDPRPECN-------YCFELRLPNLSYFVGQ-------D 483

Human   508 PVLAA------------TGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVS 560
            |.:.|            :|:|.|:|:|||.:||||.|.||                      :..
  Fly   484 PQVGAKEEQAVRLPPPDSGIGSDIAKSWETSIRQAFMHVT----------------------NTQ 526

Human   561 NCQIQENV-DISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEV 624
            .|:.:|.| |:..:||||.||||||||||:||||.|:||.|:||||||||:|||||||:||:|||
  Fly   527 CCESEEQVQDMGQLYQIFPDEVLGSGQFGVVYGGVHKKTQREVAIKVIDKLRFPTKQEAQLKNEV 591

Human   625 AILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRN 689
            |||||:.|.|:||||.|||||||:|||||||.|||||||||..:.||.||:|||::||||:||:.
  Fly   592 AILQNISHCGVVNLERMFETPERIFVVMEKLKGDMLEMILSHARGRLSERVTKFLITQILIALKY 656

Human   690 LHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYN 754
            ||.:||||||||||||||:|...||||||||||:||||||||||||||||||||||||||:||||
  Fly   657 LHSQNIVHCDLKPENVLLSSDAEFPQVKLCDFGYARIIGEKSFRRSVVGTPAYLAPEVLRNKGYN 721

Human   755 RSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRK 819
            ||||||||||||||||||||||||:|||||||||||||||||||:|||..||||||||||||.||
  Fly   722 RSLDMWSVGVIIYVSLSGTFPFNEEEDINDQIQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRK 786

Human   820 RYSVDKSLSHPWLQDYQTWLDLREFETRIGE-RYITHESDDARWE 863
            ||:|||||.|.||||.||:.|||..|.::|. ||:|||:||.||:
  Fly   787 RYTVDKSLLHYWLQDKQTYRDLRNLEAQVGAGRYLTHEADDLRWD 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKD3	NP_005804.1	C1_PKD3_rpt1	145..219	CDD:410391	47/77 (61%)
		C1_PKD3_rpt2	267..335	CDD:410394	38/116 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..371		8/38 (21%)
		PH_PKD	410..534	CDD:269945	61/139 (44%)
		STKc_PKD	572..831	CDD:270984	214/258 (83%)
PKD	NP_001262705.1	C1_1	109..154	CDD:278556	37/44 (84%)
		C1	223..272	CDD:197519	31/48 (65%)
		PH_PKD	396..522	CDD:269945	61/139 (44%)
		STKc_PKD	539..798	CDD:270984	214/258 (83%)
		S_TKc	547..799	CDD:214567	209/251 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159970
Domainoid	1	1.000	436	1.000	Domainoid score	I569
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2055
Inparanoid	1	1.050	842	1.000	Inparanoid score	I447
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48438
OrthoDB	1	1.010	-	-		D182843at33208
OrthoFinder	1	1.000	-	-		FOG0002280
OrthoInspector	1	1.000	-	-		otm41732
orthoMCL	1	0.900	-	-		OOG6_103473
Panther	1	1.100	-	-	O	PTHR22968
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2489
SonicParanoid	1	1.000	-	-		X1509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940