Protein Alignment PRKD3 and ire1

DIOPT Version :9

• Sequence 1: NP_005804.1
• Gene: PRKD3 / 23683
• HGNCID: 9408
• Length: 890
• Species: Homo sapiens
• Sequence 2: NP_593384.1
• Gene: ire1 / 2542776
• PomBaseID: SPAC167.01
• Length: 1072
• Species: Schizosaccharomyces pombe
• Alignment Length: 1040
• Identity: 204/1040 - (19%)
• Similarity: 328/1040 - (31%)
• Gaps: 397/1040 - (38%)

Human   103 FGMYDK---------ILLFRHDMNS----ENILQLITSADEIHEGDLVEVVLSALATVEDFQIRP 154
            |..:||         :.||....:|    :.:|:|.::.:...|..|....:  :|||:.
pombe    35 FNYFDKRTNGKANNELALFSPTADSPSSVDGVLELPSAENVFAESSLYNAFI--VATVDG----- 92

Human   155 HTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPG 219
               .:|||...|     |:.||.|....    ..||:|.|.                 .|..|..
pombe    93 ---SLHSYDRIT-----GQELWSLFTNA----NPGLSYTKD-----------------ENSLLSS 128

Human   220 PGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWS-GRPIWMEKMVMCRVKVPHTFAVHSYTRPT 283
            ..||     |..:.:..|.....:.:.:..|...| ...:|..:.:...:
pombe   129 KFLS-----QSNFKSYNSTHGEFYSDSTLNISYLSDDDTVWFVEPIDGGI--------------- 173

Human   284 ICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNND 348
              .|...|..||.|.....||        .....|...|....|.|..::    |...:|:.|.|
pombe   174 --LYAFNLQTGLVRLPHSIKD--------LVHASPIRLLNNNVFVGSKNT----TLFTIDVSNGD 224

Human   349 I-------------NSDSSRGLDDTEEPSPPEDKMFFLDPS--------DL-------------- 378
            |             :|..:.|......||..:..:.|.|||        ||
pombe   225 IVSQYPSGHRYETHHSVHNLGTKRDSVPSGADSDLSFKDPSGKKLSESLDLLDDFNYQVTVSNKS 289

Human   379 --DVERDEEAVKTISPS-------------TSN-------------------------------- 396
              |:.|.|..:...|.|             |.|
pombe   290 FVDIARTEYFITIYSDSNVILDLVYIDWTPTKNEIMYESFHSSSFDSKLALSSYDSSLHIVDTHS 354

Human   397 -----NIPLMRV------VQSIKHTKR--KSSTMVK----------------------------- 419
                 |||||..      :.::.|.|:  ||.|..|
pombe   355 KFIKQNIPLMSPAATVFDIVTLPHNKKIDKSQTPAKFPTSVLLRQPIDTYLETMFPQIARNKTEH 419

Human   420 -------EGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYK--EIPLSEILRISS----P 471
                   ..|..       :.:|||      .|.....|:...||.  .|||:.|..:.|    |
pombe   420 VYINHIGNAWFA-------MSERHY------PLVSLAPEASFLYYNGFYIPLNSIFGLHSLMATP 471

Human   472 RDFTNI-------------SQGS-----------------NP------------HCFEIITDTMV 494
            :.|..:             |:||                 ||            ..|..::.|:|
pombe   472 KPFFALPGLPGYDIPSYVESEGSTKTLPSIGKKPIPLLDPNPISSTPISITFWVIMFLSVSFTIV 536

Human   495 YFV--------------GENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALM-----------PV 534
            .|.              .:.|..|.:|.:        |.::...|..|:..:           .:
pombe   537 TFFSILRIRSSEVRPLKSQKNTVSINNKI--------DTSKRRRKGKRRKRVSDEHSASSNFNEI 593

Human   535 TPQASV-------------------CTSPGQGKDHKDLSTSIS--VSNCQIQENVDIS------T 572
            ..|||.                   .|.|.|    |.|.:|:.  :....:.:|.|.|      |
pombe   594 ESQASFEQNQTLDILSENIVEIQDKSTDPLQ----KSLDSSLKSHLPEATVIQNTDGSVTVNSLT 654

Human   573 VYQIFADEVLGSGQFG-IVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNL-HHPGI 635
            ||    .||:|.|..| |||.|.:.  .|:||:|.: .|.|    ......|:.:||.. :||.|
pombe   655 VY----PEVIGYGSHGTIVYRGVYE--DREVAVKRV-LMEF----YDLASREITLLQQSDNHPNI 708

Human   636 VNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITK-----FMVTQILVALRNLHFKNI 695
            |...|..::.:.:::|:|....::.::|   ||....:.:.|     .::.||...:.:||..::
pombe   709 VRYYCKQKSDQFLYIVIELCKCNLSDLI---EKPIAYDDLFKSIDLVSLLYQIAFGVSHLHSLDL 770

Human   696 VHCDLKPENVLLASAEPFPQVK-------LCDFGFARII--GEKSFRRS---VVGTPAYLAPEVL 748
            ||.||||:|:||. ....|.:.       :.|||.::.:  .:.|.|.:   ..|:..:.:||:|
pombe   771 VHRDLKPQNILLV-VNNSPNLSKTRVRALISDFGLSKKLDFNQSSLRNTTFEAAGSYGWRSPEIL 834

Human   749 ------------------RSKGYNRSLDMWSVGVIIYVSLS-GTFPFNEDEDINDQIQNAAF-MY 793
                              |.:..:.:.|::::|.|.|.:|: |..||....|....|....: :.
pombe   835 SGSLSQQSKEIQVKTREGRIRQASHATDIFALGCIFYYTLTGGMHPFGSHYDCEGNILKGNYCLV 899

Human   794 PPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHESD 858
            ......|....|.|||.:::..:..||.:::..|:||...||...||   |...:.:|:...|.|
pombe   900 HLQSLGECGVLAADLIEDMIAFEPSKRPTIEVVLNHPLFWDYAKKLD---FLIDVSDRFEVEERD 961

Human   859  858
            pombe   962  961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKD3	NP_005804.1	C1_PKD3_rpt1	145..219	CDD:410391	17/73 (23%)
		C1_PKD3_rpt2	267..335	CDD:410394	11/67 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	332..371		9/51 (18%)
		PH_PKD	410..534	CDD:269945	35/234 (15%)
		STKc_PKD	572..831	CDD:270984	75/297 (25%)
ire1	NP_593384.1	Luminal_IRE1_like	82..440	CDD:276097	72/440 (16%)
		STKc_IRE1	652..939	CDD:270884	76/301 (25%)
		S_TKc	658..938	CDD:214567	73/290 (25%)
		RNase_Ire1	942..1070	CDD:199217	6/23 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910