DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PRKD3 and plo1

DIOPT Version :9

Sequence 1:	NP_005804.1	Gene:	PRKD3 / 23683	HGNCID:	9408	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_593647.1	Gene:	plo1 / 2541957	PomBaseID:	SPAC23C11.16	Length:	683	Species:	Schizosaccharomyces pombe

Alignment Length:	316	Identity:	91/316 - (28%)
Similarity:	161/316 - (50%)	Gaps:	39/316 - (12%)

- Green bases have known domain annotations that are detailed below.

Human   526 AIRQALMPVTPQ-----ASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSG 585
            ||::....:||:     :.:|.:|.....:.             ::|: ..|.|     :.:|.|
pombe     5 AIKEPKTAITPKKKSKASRLCFTPPTNLHNN-------------KKNI-FYTRY-----DCIGEG 50

Human   586 QFGIVYGGKHRKTGRDVAIKVIDKMRFPT-KQESQLRNEVAILQNLHHPGIVNLECMFETPERVF 649
            .|...:..|. ..|...|.|||.|..... |.:.:|..|:.:.|::.||.||.....||....::
pombe    51 GFARCFRVKD-NYGNIYAAKVIAKRSLQNDKTKLKLFGEIKVHQSMSHPNIVGFIDCFEDSTNIY 114

Human   650 VVMEKL-HGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPF 713
            :::|.. |..::|::  .::.:|.|...::::.|||.||:.:|.|.::|.|||..|::|..:.
pombe   115 LILELCEHKSLMELL--RKRKQLTEPEVRYLMMQILGALKYMHKKRVIHRDLKLGNIMLDESN-- 175

Human   714 PQVKLCDFGFARIIGEKSFRR-SVVGTPAYLAPEVL--RSKGYNRSLDMWSVGVIIYVSLSGTFP 775
             .||:.|||.|.::.:...|: ::.|||.|:|||:|  ..:|::..:|:||.||::|..|.|..|
pombe   176 -NVKIGDFGLAALLMDDEERKMTICGTPNYIAPEILFNSKEGHSFEVDLWSAGVVMYALLIGKPP 239

Human   776 FNEDE--DINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSH 829
            |.:.|  .|..:|:..::.:|.|.  :||.||.|||::||......|.|:|..:.|
pombe   240 FQDKEVKTIYRKIKANSYSFPSNV--DISAEAKDLISSLLTHDPSIRPSIDDIVDH 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKD3	NP_005804.1	C1_PKD3_rpt1	145..219	CDD:410391
		C1_PKD3_rpt2	267..335	CDD:410394
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..371
		PH_PKD	410..534	CDD:269945	2/7 (29%)
		STKc_PKD	572..831	CDD:270984	84/265 (32%)
plo1	NP_593647.1	STKc_PLK	41..296	CDD:271001	84/266 (32%)
		S_TKc	41..296	CDD:214567	84/266 (32%)
		POLO_box_1	490..580	CDD:240561
		POLO_box_2	599..676	CDD:240560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910