DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKD3 and dkf-2

DIOPT Version :9

Sequence 1:	NP_005804.1	Gene:	PRKD3 / 23683	HGNCID:	9408	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_001256725.1	Gene:	dkf-2 / 180121	WormBaseID:	WBGene00012019	Length:	1095	Species:	Caenorhabditis elegans

Alignment Length:	958	Identity:	467/958 - (48%)
Similarity:	594/958 - (62%)	Gaps:	132/958 - (13%)

- Green bases have known domain annotations that are detailed below.

Human     8 PSAQKSVLPTAIPAVLPAA----------SPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSF 62
            |.|.:..|||.:....|..          :|...|        .|..:|    ::|...:..::|
Worm   177 PGAHQFQLPTLLVTSTPTTVFDHSDDEVWTPYRPP--------PNREYS----SSSEPMMGDLTF 229

Human    63 LLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITS 127
            .||.|:.::|:.:|..|::|..:::.....:.:.:||.|...:.|.|||::||:.|.|||||||:
Worm   230 RLQSGIHKKSIAVEGTEIALRDLRNEALQFIKEIYPEKGCSSLEDYILLYKHDLRSINILQLITT 294

Human   128 ADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNY 192
            :.::.:|.|||||:.:....|...:.||||:|||||.|||||:|||:|:|||:|||||.||||||
Worm   295 SSDVTDGTLVEVVIGSCPQNERIVVHPHTLFVHSYKVPTFCDFCGELLFGLVKQGLKCFGCGLNY 359

Human   193 HKRCAFKIPNNCSGVRKRRLSNVSL-PG-------------------PGLSVPRP-------LQP 230
            |||||.||||||:|.::||.|.:.| |.                   ..|...||       ..|
Worm   360 HKRCASKIPNNCNGSKQRRPSAIPLSPSNSNILNLNERRHSRRESCLEALDAARPSSTLGGAATP 424

Human   231 EYVALPSEE------SHVHQEPSK-RIPSWSGRPIWMEKMVMCRVK--VPHTFAVHSYTRPTICQ 286
            . :.:.|::      .:..|.|.| |..||||||:|||.....|||  |||||.||||..||:||
Worm   425 N-IFITSDDCGDAVGGNYLQMPRKDRSCSWSGRPLWMEIAEATRVKLQVPHTFQVHSYKLPTVCQ 488

Human   287 YCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVT----FNGEPSSLGTDTDIPMD---- 343
            :||:|||||.||||||:|||:||||:|:..|.:||.|...    |.|..:..||.....||
Worm   489 HCKKLLKGLIRQGMQCRDCKYNCHKKCSEHVAKDCSGNTKASQFFLGSQADDGTSLTGSMDNLRM 553

Human   344 ----IDNNDINSDSSRGLDD--------------TEEPSPPEDKMFFLDPSD------------- 377
                ..::...|.:|...||              ...||.|      |..|:
Worm   554 CSVPFGSDQSTSGASEDRDDDLSLRSGSGAHKKAQNTPSAP------LQGSEGSGSPGPVVSFAA 612

Human   378 --LDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRL 440
              |....|::.:.    |.|.||||||||.|.|.||||::.::||||:||||.:.|:||:|||||
Worm   613 NALSNMPDDDVIS----SESANIPLMRVVMSKKQTKRKNNKLLKEGWIVHYTDQQNMRKKHYWRL 673

Human   441 DSKCLTLFQNESGSKYYKEIPLSEILRIS-SPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDS 504
            |:|.:|::|:|:.::|||||||:|||.:| ||.|.|      ..:.|||.|...|||:..:..|.
Worm   674 DTKGITMYQDENTTRYYKEIPLNEILNVSMSPPDKT------ADYLFEIRTGVCVYFISGSPSDE 732

Human   505 SHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSN--CQIQEN 567
            .        |..|| ||||..||:.||||||||:||.  .|:..|...:.|.....:  .:||..
Worm   733 K--------GSSLD-AQSWTTAIQSALMPVTPQSSVV--GGKRIDKLKVPTEGETGHLGAKIQTE 786

Human   568 VDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHH 632
            .:.|.:|||||:|||||||||.||||.||:.|:.||:|:|||::||..:|..||.||.||:.:.|
Worm   787 HEFSQLYQIFAEEVLGSGQFGTVYGGIHRRNGQHVAVKLIDKLKFPPNKEDLLRAEVQILEKVDH 851

Human   633 PGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVH 697
            ||:|:...|.||.:|:|||||||.||||||||||||.||.||.|:|:|.|||.|||.||..||||
Worm   852 PGVVHFMQMLETTDRIFVVMEKLKGDMLEMILSSEKGRLSERTTQFLVAQILEALRYLHHLNIVH 916

Human   698 CDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSV 762
            |||||||:||.|...|||||||||||||||||||||||||||||||||||||:||:|||||||||
Worm   917 CDLKPENILLNSNSDFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGFNRSLDMWSV 981

Human   763 GVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSL 827
            |||:|||||||||||||||||||||||.|||||.||:|||..||:.||.||||||.|||:|.|:.
Worm   982 GVIVYVSLSGTFPFNEDEDINDQIQNAEFMYPPTPWKEISENAIEFINGLLQVKMSKRYTVTKAQ 1046

Human   828 SHPWLQDYQTWLDLREFETRIGERYITHESDDARWEIHAYTHNL--VY 873
            |..|:|:|..|.|||..|..:|:|::||||||.||:.:...||:  ||
Worm  1047 SQIWMQNYTLWSDLRVLEKAVGQRFVTHESDDVRWQAYEKEHNVTPVY 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKD3	NP_005804.1	C1_PKD3_rpt1	145..219	CDD:410391	49/74 (66%)
		C1_PKD3_rpt2	267..335	CDD:410394	43/73 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..371		11/60 (18%)
		PH_PKD	410..534	CDD:269945	60/124 (48%)
		STKc_PKD	572..831	CDD:270984	192/258 (74%)
dkf-2	NP_001256725.1	C1_1	326..371	CDD:278556	37/44 (84%)
		C1	474..523	CDD:237996	33/48 (69%)
		PH_PKD	643..753	CDD:269945	60/124 (48%)
		STKc_PKD	791..1050	CDD:270984	192/258 (74%)
		Pkinase	798..1051	CDD:278497	187/252 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161471973
Domainoid	1	1.000	388	1.000	Domainoid score	I450
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2055
Inparanoid	1	1.050	833	1.000	Inparanoid score	I242
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48438
OrthoDB	1	1.010	-	-		D182843at33208
OrthoFinder	1	1.000	-	-		FOG0002280
OrthoInspector	1	1.000	-	-		otm15030
orthoMCL	1	0.900	-	-		OOG6_103473
Panther	1	1.100	-	-	O	PTHR22968
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2489
SonicParanoid	1	1.000	-	-		X1509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940