DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKD3 and prkd1

DIOPT Version :9

Sequence 1:	NP_005804.1	Gene:	PRKD3 / 23683	HGNCID:	9408	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_001120884.1	Gene:	prkd1 / 100151704	XenbaseID:	XB-GENE-487626	Length:	860	Species:	Xenopus tropicalis

Alignment Length:	892	Identity:	607/892 - (68%)
Similarity:	701/892 - (78%)	Gaps:	75/892 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    24 PAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTI-EAQELSLSAVKD 87
            |...|.|...||||.:                        :||||:||.|.: |..||||.||::
Frog     5 PVIRPPSPAGTGLSLQ------------------------IQIGLSREPVLLPEPGELSLGAVRE 45

Human    88 LVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQI 152
            :.||||.||||||||:||||||||||||.||||||||:.|..:|.||||:||||||.||.|||||
Frog    46 MACSIVDQKFPECGFYGMYDKILLFRHDPNSENILQLVKSEADIQEGDLIEVVLSASATFEDFQI 110

Human   153 RPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSL 217
            |||.|:||||:||.|||:|||||||||||||||||||||||||||||||||||||||||||||||
Frog   111 RPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSL 175

Human   218 PGPGLSVPRPLQPEYVALPSEESHVHQEPS-----KRIPSWS----GRPIWMEKMVMCRVKVPHT 273
              .|||..|.|..|.::...:|..:.:.||     :...|.|    ||||.::|..:.:||||||
Frog   176 --TGLSSIRTLSVEPLSSAPDEPLLQKSPSESFLGRHSRSGSQLHIGRPIKLDKFFLTKVKVPHT 238

Human   274 FAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSL---- 334
            |.:|||||||:||:||:|||||||||:|||||||||||||||:||.:||||...||:.|.:
Frog   239 FVIHSYTRPTVCQHCKKLLKGLFRQGLQCKDCKFNCHKRCASRVPHNCLGEDAINGDLSDVMMEE 303

Human   335 GTDTD--IPMDIDNNDINSDSSRGL-----DDTEEPSPPEDKMFFLDPSDLDVERDEEAVKTISP 392
            |:|.:  .|.|:|.:. .:||...:     ::.|...|.:|:    |.||          :||||
Frog   304 GSDDNESRPEDMDESP-TTDSEGSISGCRSENGEMQEPDQDQ----DASD----------RTISP 353

Human   393 STSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYY 457
            |.||||||||||||:||||||||:::||||||||||:|.:||||||||||||:|||||::|||||
Frog   354 SASNNIPLMRVVQSVKHTKRKSSSVMKEGWMVHYTSKDPMRKRHYWRLDSKCITLFQNDTGSKYY 418

Human   458 KEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGEN-----NGDSSHNPVLAATGVGL 517
            |||||||||.:...:|.:.:..|:|||||||.|..:||:||||     ..|..:  |:..:|.||
Frog   419 KEIPLSEILSLEPAKDLSLLCPGANPHCFEITTANVVYYVGENLPQPVPPDMGN--VMLTSGAGL 481

Human   518 DVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVL 582
            |:|:.||.||:.|||||.|:.:   :.| ...|:|:|.||||||||:.||||||:|||||.||||
Frog   482 DIARMWEIAIQHALMPVNPKGA---NDG-STQHRDVSISISVSNCQVHENVDISSVYQIFPDEVL 542

Human   583 GSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPER 647
            |||||||||||||||||||||||:|||:||||||||||||||||||||||.|:||||||||||||
Frog   543 GSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHQGVVNLECMFETPER 607

Human   648 VFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEP 712
            |||||||||||||||||||||.|||||||||:|||||||||:|||||||||||||||||||||:|
Frog   608 VFVVMEKLHGDMLEMILSSEKGRLPERITKFLVTQILVALRHLHFKNIVHCDLKPENVLLASADP 672

Human   713 FPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFN 777
            |||||||||||||||||||||||||||||||||||||::||||||||||||||||||||||||||
Frog   673 FPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNRGYNRSLDMWSVGVIIYVSLSGTFPFN 737

Human   778 EDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLR 842
            |||||:|||||||||||||||:|||.:|||||||||||||||||||||:|:||||||||||||||
Frog   738 EDEDIHDQIQNAAFMYPPNPWKEISPDAIDLINNLLQVKMRKRYSVDKTLNHPWLQDYQTWLDLR 802

Human   843 EFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPN--PDDME 887
            |.|.:||||||||||||.||:.::....|:||.|.:..|:  |:|.|
Frog   803 ELECKIGERYITHESDDPRWQQYSEDCRLLYPPHLLPPPSYEPEDAE 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKD3	NP_005804.1	C1_PKD3_rpt1	145..219	CDD:410391	67/73 (92%)
		C1_PKD3_rpt2	267..335	CDD:410394	51/71 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..371		11/49 (22%)
		PH_PKD	410..534	CDD:269945	78/128 (61%)
		STKc_PKD	572..831	CDD:270984	240/258 (93%)
prkd1	NP_001120884.1	C1_1	113..162	CDD:365894	43/48 (90%)
		C1	237..286	CDD:237996	40/48 (83%)
		PH_PKD	371..498	CDD:269945	78/128 (61%)
		STKc_PKD	532..791	CDD:270984	240/258 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I34341
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D182843at33208
OrthoFinder	1	1.000	-	-		FOG0002280
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1509
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010