Protein Alignment STX12 and PEP12

DIOPT Version :10

• Sequence 1: NP_803173.1
• Gene: STX12 / 23673
• HGNCID: 11430
• Length: 276
• Species: Homo sapiens
• Sequence 2: NP_014679.1
• Gene: PEP12 / 854201
• SGDID: S000005562
• Length: 288
• Species: Saccharomyces cerevisiae
• Alignment Length: 263
• Identity: 72/263 - (27%)
• Similarity: 138/263 - (52%)
• Gaps: 36/263 - (13%)

Human    30 SGNIQRISQATAQIKNLMSQLGTKQDSSKLQENLQQLQHSTNQLAKETNELLKELGSLPLPLSTS 94
            :|.|..:.|.||.:|:.:.:   ...|:|:.|.:.:     ..:||     ::|:|.|...::||
Yeast    41 NGQISTLQQFTATLKSFIDR---GDVSAKVVERINK-----RSVAK-----IEEIGGLIKKVNTS 92

Human    95 EQRQ-----------QRLQKERLMNDFSAALNNFQAVQR-------RVSEKEKESI-ARARAGSR 140
            .::.           |.:.:|:|:.|.|.:...||.:||       :|:|:.|||: |...|...
Yeast    93 VKKMDAIEEASLDKTQIIAREKLVRDVSYSFQEFQGIQRQFTQVMKQVNERAKESLEASEMANDA 157

Human   141 LSAEERQREEQLVSFDSHEEWNQMQSQEDEVAITE--QDLELIKERETAIRQLEADILDVNQIFK 203
            ...:|.||:..  |..:....:|:..:.|.:...|  ....||::|:..|..:|..|.::|::||
Yeast   158 ALLDEEQRQNS--SKSTRIPGSQIVIERDPINNEEFAYQQNLIEQRDQEISNIERGITELNEVFK 220

Human   204 DLAMMIHDQGDLIDSIEANVESSEVHVERATEQLQRAAYYQKKSRKKMCILVLVLSVIILILGLI 268
            ||..::..||.|:|:||||:.::..:.:.|:::|::|..|||::.:....|::||.|::|.:.||
Yeast   221 DLGSVVQQQGVLVDNIEANIYTTSDNTQLASDELRKAMRYQKRTSRWRVYLLIVLLVMLLFIFLI 285

Human   269 IWL 271
            :.|
Yeast   286 MKL 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STX12	NP_803173.1	Syntaxin_2	30..132	CDD:464199	29/119 (24%)
		SNARE_syntaxin12	181..247	CDD:277229	24/65 (37%)
PEP12	NP_014679.1	COG5325	4..288	CDD:227635	71/261 (27%)