DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BACE1 and cathD

DIOPT Version :9

Sequence 1:	NP_036236.1	Gene:	BACE1 / 23621	HGNCID:	933	Length:	501	Species:	Homo sapiens
Sequence 2:	NP_001334713.1	Gene:	cathD / 45268	FlyBaseID:	FBgn0029093	Length:	392	Species:	Drosophila melanogaster

Alignment Length:	408	Identity:	107/408 - (26%)
Similarity:	167/408 - (40%)	Gaps:	84/408 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    52 EEPG-----------RRGSFVEM---VDNLRGKSGQG-------------YYVEMTVGSPPQTLN 89
            |:||           .|..|.::   :..||.:.|.|             ||..:.:|||||...
  Fly    23 EKPGLLRVPLHKFQSARRHFADVGTELQQLRIRYGGGDVPEPLSNYMDAQYYGPIAIGSPPQNFR 87

Human    90 ILVDTGSSNFAVGAAP-H-----PFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSI 148
            ::.||||||..|.:.. |     ..:|..|....|.||........:.|..|...|.|.||.|||
  Fly    88 VVFDTGSSNLWVPSKKCHLTNIACLMHNKYDASKSKTYTKNGTEFAIQYGSGSLSGYLSTDTVSI 152

Human   149 PHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSL 213
            . |.::..:....|::|....|: .:.::|||||.|..|:  .|.::|.|.::.:|    .|.|.
  Fly   153 A-GLDIKDQTFAEALSEPGLVFV-AAKFDGILGLGYNSIS--VDKVKPPFYAMYEQ----GLISA 209

Human   214 QLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDC 278
            .:  ..|.||: :..:..||.:|.||.|.:.|||...|.|:.|:.|:::.:....|.  ||:: |
  Fly   210 PV--FSFYLNR-DPASPEGGEIIFGGSDPNHYTGEFTYLPVTRKAYWQIKMDAASIG--DLQL-C 268

Human   279 KEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPV 343
            |  ...:.|.|:||:.:..|.:         :|.|..:|......:|.|.|. .....|.  .||
  Fly   269 K--GGCQVIADTGTSLIAAPLE---------EATSINQKIGGTPIIGGQYVV-SCDLIPQ--LPV 319

Human   344 ISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGT----------VMGAVI 398
            |...|.|    ::|.:.  .:.|:..|..:.       |........|.          ::|.|.
  Fly   320 IKFVLGG----KTFELE--GKDYILRVAQMG-------KTICLSGFMGLDIPPPNGPLWILGDVF 371

Human   399 MEGFYVVFDRARKRIGFA 416
            :..:|..||....|:|||
  Fly   372 IGKYYTEFDMGNDRVGFA 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BACE1	NP_036236.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..58		3/16 (19%)
		beta_secretase_like	72..437	CDD:133140	100/374 (27%)
		Interaction with RTN3	479..501
		DXXLL. /evidence=ECO:0000269\|PubMed:15886016	496..500
cathD	NP_001334713.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810