DRSC/TRiP Functional Genomics Resources

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Protein Alignment BACE1 and CG5863

DIOPT Version :10

Sequence 1:NP_036236.1 Gene:BACE1 / 23621 HGNCID:933 Length:501 Species:Homo sapiens
Sequence 2:NP_650623.1 Gene:CG5863 / 42096 FlyBaseID:FBgn0038507 Length:395 Species:Drosophila melanogaster


Alignment Length:459 Identity:113/459 - (24%)
Similarity:184/459 - (40%) Gaps:117/459 - (25%)


- Green bases have known domain annotations that are detailed below.


Human     7 WLLLWM-------GAGVLPAHGTQHGIRLPL-------------RSG----------LGGAPLGL 41
            ||.||:       ..|.|        ||:|:             |:|          :||     
  Fly     8 WLSLWILCLFWAKCQGQL--------IRIPMQFQASFMASRRQHRAGRSSLLAKYNVVGG----- 59

Human    42 RLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAP- 105
                     .|...|.|...|.:||   :....|...:::|||.|..|:|.||||:|..|.:|. 
  Fly    60 ---------QEVTSRNGGATETLDN---RLNLEYAGPISIGSPGQPFNMLFDTGSANLWVPSAEC 112

Human   106 --------HPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAA 162
                    |   |..|....|||:....:...:.|..|...|.|..|.|:|  |..|........
  Fly   113 SPKSVACHH---HHRYNASASSTFVPDGRRFSIAYGTGSLSGRLAQDTVAI--GQLVVQNQTFGM 172

Human   163 IT-ESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPN-LFSLQLCGAGFPLNQS 225
            .| |....|:: :|:.||:||.:..||  :..::|.|:|:..|..|.. :||..|     ..|.|
  Fly   173 ATHEPGPTFVD-TNFAGIVGLGFRPIA--ELGIKPLFESMCDQQLVDECVFSFYL-----KRNGS 229

Human   226 EVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDS 290
            |   ..||.::.||:|.:.::|||.|.|:....|::..:..:|:.|..:..:      .::|.|:
  Fly   230 E---RKGGELLFGGVDKTKFSGSLTYVPLTHAGYWQFPLDVIEVAGTRINQN------RQAIADT 285

Human   291 GTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTN 354
            ||:.|..|.:.: ..:.|:.....|..       .|.|: |.:..:.|..:|      ::|    
  Fly   286 GTSLLAAPPREY-LIINSLLGGLPTSN-------NEYLLNCSEIDSLPEIVF------IIG---- 332

Human   355 QSFRITILPQQYLRPVEDVATSQDD----CYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGF 415
             ..|..:.|:.|:     ::.:.||    |........:...::|.|.:..:|..||..::||||
  Fly   333 -GQRFGLQPRDYV-----MSATNDDGSSICLSAFTLMDAEFWILGDVFIGRYYTAFDAGQRRIGF 391

Human   416 AVSA 419
            |.:|
  Fly   392 APAA 395

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BACE1NP_036236.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 39..58 2/18 (11%)
beta_secretase_like 72..437 CDD:133140 94/364 (26%)
Interaction with RTN3 479..501
DXXLL. /evidence=ECO:0000269|PubMed:15886016 496..500
CG5863NP_650623.1 Asp 80..394 CDD:394983 93/359 (26%)
Blue background indicates that the domain is not in the aligned region.

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