DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BACE1 and CG5863

DIOPT Version :9

Sequence 1:	NP_036236.1	Gene:	BACE1 / 23621	HGNCID:	933	Length:	501	Species:	Homo sapiens
Sequence 2:	NP_650623.1	Gene:	CG5863 / 42096	FlyBaseID:	FBgn0038507	Length:	395	Species:	Drosophila melanogaster

Alignment Length:	459	Identity:	113/459 - (24%)
Similarity:	184/459 - (40%)	Gaps:	117/459 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     7 WLLLWM-------GAGVLPAHGTQHGIRLPL-------------RSG----------LGGAPLGL 41
            ||.||:       ..|.|        ||:|:             |:|          :||
  Fly     8 WLSLWILCLFWAKCQGQL--------IRIPMQFQASFMASRRQHRAGRSSLLAKYNVVGG----- 59

Human    42 RLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAP- 105
                     .|...|.|...|.:||   :....|...:::|||.|..|:|.||||:|..|.:|.
  Fly    60 ---------QEVTSRNGGATETLDN---RLNLEYAGPISIGSPGQPFNMLFDTGSANLWVPSAEC 112

Human   106 --------HPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAA 162
                    |   |..|....|||:....:...:.|..|...|.|..|.|:|  |..|........
  Fly   113 SPKSVACHH---HHRYNASASSTFVPDGRRFSIAYGTGSLSGRLAQDTVAI--GQLVVQNQTFGM 172

Human   163 IT-ESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPN-LFSLQLCGAGFPLNQS 225
            .| |....|:: :|:.||:||.:..||  :..::|.|:|:..|..|.. :||..|     ..|.|
  Fly   173 ATHEPGPTFVD-TNFAGIVGLGFRPIA--ELGIKPLFESMCDQQLVDECVFSFYL-----KRNGS 229

Human   226 EVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDS 290
            |   ..||.::.||:|.:.::|||.|.|:....|::..:..:|:.|..:..:      .::|.|:
  Fly   230 E---RKGGELLFGGVDKTKFSGSLTYVPLTHAGYWQFPLDVIEVAGTRINQN------RQAIADT 285

Human   291 GTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTN 354
            ||:.|..|.:.: ..:.|:.....|..       .|.|: |.:..:.|..:|      ::|
  Fly   286 GTSLLAAPPREY-LIINSLLGGLPTSN-------NEYLLNCSEIDSLPEIVF------IIG---- 332

Human   355 QSFRITILPQQYLRPVEDVATSQDD----CYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGF 415
             ..|..:.|:.|:     ::.:.||    |........:...::|.|.:..:|..||..::||||
  Fly   333 -GQRFGLQPRDYV-----MSATNDDGSSICLSAFTLMDAEFWILGDVFIGRYYTAFDAGQRRIGF 391

Human   416 AVSA 419
            |.:|
  Fly   392 APAA 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BACE1	NP_036236.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..58		2/18 (11%)
		beta_secretase_like	72..437	CDD:133140	94/364 (26%)
		Interaction with RTN3	479..501
		DXXLL. /evidence=ECO:0000269\|PubMed:15886016	496..500
CG5863	NP_650623.1	pepsin_retropepsin_like	71..392	CDD:299705	94/369 (25%)
CG5863	NP_650623.1	Asp	80..394	CDD:278455	93/359 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810