DRSC/TRiP Functional Genomics Resources

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Protein Alignment BACE1 and CG5860

DIOPT Version :10

Sequence 1:NP_036236.1 Gene:BACE1 / 23621 HGNCID:933 Length:501 Species:Homo sapiens
Sequence 2:NP_650622.1 Gene:CG5860 / 42095 FlyBaseID:FBgn0038506 Length:370 Species:Drosophila melanogaster


Alignment Length:457 Identity:99/457 - (21%)
Similarity:172/457 - (37%) Gaps:131/457 - (28%)


- Green bases have known domain annotations that are detailed below.


Human     1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPL--------------RSGL-GGAPLGLRLPRETDEE 50
            |.:.|.:||.::..    ...||..:::||              ||.. ||..|.|:|..:|...
  Fly     1 MLRVLCFLLAFLSL----VFATQKILKVPLYVRRSFNESEVFLARSATEGGETLQLQLLLQTHNN 61

Human    51 PEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL------ 109
            .|                      ||..:.:|:|.|...::.||||||..:.:...|..      
  Fly    62 ME----------------------YYGTIAMGNPRQNFTVIFDTGSSNTWLPSVNCPMSNSACQN 104

Human   110 HRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFI--- 171
            ||.|....||:|....:...:.|..|...|.|..|.:.|       ..|.:...|..:..|:   
  Fly   105 HRKYNSSRSSSYIPDGRNFTLRYGSGMVVGYLSKDTMHI-------AGAELPHFTFGESLFLQHF 162

Human   172 --NGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGS 234
              :...::|::||....::..:.:  ||.:.|..|.      .|:.|.....|.:..      ..
  Fly   163 AFSSVKFDGLVGLGLGVLSWSNTT--PFLELLCAQR------LLEKCVFSVYLRRDP------RE 213

Human   235 MIIGGIDHSLYTGSLWYTPIRR--EWYYEVIIVRV---EINGQDLKMDCKEYNYDKSIVDSGTTN 294
            ::.||.|.|.:.|.|.|.|:.:  .|..::....|   :|.|:           ..:|:|:||:.
  Fly   214 IVFGGFDESKFEGKLHYVPVSQWHTWSLQISKSSVGTKQIGGK-----------SNAILDTGTSL 267

Human   295 LRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNI--------FPVISL-YLMG 350
            :.:|::.:...:.::.|     |..:|::    :|..::|:.| ||        ||:.|. |:| 
  Fly   268 VLVPQQTYHNLLNTLSA-----KLQNGYF----VVACKSGSLP-NINILIGDKVFPLTSSDYIM- 321

Human   351 EVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTG-TVMGAVIMEGFYVVFDRARKRIG 414
                                 :|...:......||:..:.| .|:|.:.:..:|.|||...||||
  Fly   322 ---------------------EVLLDRKPACVLAIAPINRGFWVLGDIFLRRYYTVFDATEKRIG 365

Human   415 FA 416
            .|
  Fly   366 LA 367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BACE1NP_036236.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 39..58 5/18 (28%)
beta_secretase_like 72..437 CDD:133140 82/371 (22%)
Interaction with RTN3 479..501
DXXLL. /evidence=ECO:0000269|PubMed:15886016 496..500
CG5860NP_650622.1 Asp 63..369 CDD:394983 83/391 (21%)
Blue background indicates that the domain is not in the aligned region.

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