DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BACE1 and CG17283

DIOPT Version :9

Sequence 1:	NP_036236.1	Gene:	BACE1 / 23621	HGNCID:	933	Length:	501	Species:	Homo sapiens
Sequence 2:	NP_650621.1	Gene:	CG17283 / 42094	FlyBaseID:	FBgn0038505	Length:	465	Species:	Drosophila melanogaster

Alignment Length:	399	Identity:	100/399 - (25%)
Similarity:	155/399 - (38%)	Gaps:	86/399 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    59 SFVEMVDNLRGK---------------SGQG---------YYVEMTVGSPPQTLNILVDTGSSNF 99
            :||...||||.:               ||..         |..:|.:|:|.|...:|.||||||.
  Fly   110 NFVRTTDNLRSEKAFLANRYGFSFAKSSGTATLKNTANMEYTCKMNIGTPKQKFTVLPDTGSSNI 174

Human   100 AVGAAPHPFL-------HRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVR 157
            .|   |.|..       |:.|....||||....|...:.|..|...|.|..|.|.|. |..||.:
  Fly   175 WV---PGPHCKSKACKKHKQYHPAKSSTYVKNGKSFAITYGSGSVAGVLAKDTVRIA-GLVVTNQ 235

Human   158 ANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNL-FSLQLCGAGFP 221
            .......|....|:. ||::|||||.|..||  .|:::....::..:..:.:. |::.:.|.|
  Fly   236 TFAMTTKEPGTTFVT-SNFDGILGLGYRSIA--VDNVKTLVQNMCSEDVITSCKFAICMKGGG-- 295

Human   222 LNQSEVLASVGGSMIIGGIDHSLYTG--SLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYD 284
                  .:|.||::|.|..:.|.|:|  |..|||:.::.|::..:..:.:.|      .|.....
  Fly   296 ------SSSRGGAIIFGSSNTSAYSGSNSYTYTPVTKKGYWQFTLQDIYVGG------TKVSGSV 348

Human   285 KSIVDSGTTNLRLPKKVFEAAVKSI--KAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLY 347
            ::||||||:.:..|..::....|.|  :|.||.|             ||......   .|..:..
  Fly   349 QAIVDSGTSLITAPTAIYNKINKVIGCRATSSGE-------------CWMKCAKK---IPDFTFV 397

Human   348 LMGE---VTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRA 409
            :.|:   |.....::.:...:          .:..|............::|...:..|...||.|
  Fly   398 IAGKKFVVKGNKMKLKVRTNR----------GRTVCISAVTEVPDEPVILGDAFIRHFCTEFDLA 452

Human   410 RKRIGFAVS 418
            ..|||||.:
  Fly   453 NNRIGFAAT 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BACE1	NP_036236.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..58
		beta_secretase_like	72..437	CDD:133140	93/371 (25%)
		Interaction with RTN3	479..501
		DXXLL. /evidence=ECO:0000269\|PubMed:15886016	496..500
CG17283	NP_650621.1	pepsin_retropepsin_like	142..459	CDD:299705	90/363 (25%)
CG17283	NP_650621.1	Asp	149..460	CDD:278455	91/357 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810