| Sequence 1: | NP_036236.1 | Gene: | BACE1 / 23621 | HGNCID: | 933 | Length: | 501 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_610961.1 | Gene: | CG10104 / 36602 | FlyBaseID: | FBgn0033933 | Length: | 404 | Species: | Drosophila melanogaster |
| Alignment Length: | 401 | Identity: | 87/401 - (21%) |
|---|---|---|---|
| Similarity: | 133/401 - (33%) | Gaps: | 128/401 - (31%) |
- Green bases have known domain annotations that are detailed below.
|
Human 153 LDHIAENILSYLD-------AKSLCAAELVCKEWYRVTSDGM-LWKKLIERMVRTDSLWRGLAER 209
Human 210 RGWGQYLFKNKPPDE--NAPP--------NSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRS 264
Human 265 ETSKGVYCLQYDDQKIVSGLRDNTIKIWDKSTLECKRILTG--------HT-GSVLCLQYDERVI 320
Human 321 ITGSSD----STVRVWDVNA--GEMLNTLIHHCEAVLH---------LRFNNGMMVTCSKDRSIA 370
Human 371 VWDMASPTDITLRRVLVGHRA------------AVNVVDFDDKYIVSASGDRTIKVWNTSTCEFV 423
Human 424 RTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIEC---GACLRVLEGHEELVRCIRFDNKRIVS 485
Human 486 GAYDGKIKVWD 496 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| BACE1 | NP_036236.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 39..58 | ||
| beta_secretase_like | 72..437 | CDD:133140 | 73/337 (22%) | ||
| Interaction with RTN3 | 479..501 | 4/18 (22%) | |||
| DXXLL. /evidence=ECO:0000269|PubMed:15886016 | 496..500 | 0/1 (0%) | |||
| CG10104 | NP_610961.1 | pepsin_retropepsin_like | 76..400 | CDD:472175 | 69/312 (22%) |
| Blue background indicates that the domain is not in the aligned region. | |||||