DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BACE1 and CG17134

DIOPT Version :9

Sequence 1:	NP_036236.1	Gene:	BACE1 / 23621	HGNCID:	933	Length:	501	Species:	Homo sapiens
Sequence 2:	NP_609458.1	Gene:	CG17134 / 34494	FlyBaseID:	FBgn0032304	Length:	391	Species:	Drosophila melanogaster

Alignment Length:	361	Identity:	105/361 - (29%)
Similarity:	166/361 - (45%)	Gaps:	49/361 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    65 DNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRD 123
            :||.......||..:.:|:|.|..|||.||||:|..|.:|..|.      .|..|....||||..
  Fly    66 ENLHNSMNNEYYGVIAIGTPEQRFNILFDTGSANLWVPSASCPASNTACQRHNKYDSSASSTYVA 130

Human   124 LRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
            ..:...:.|..|...|.|..|:|:|. |.::..:....|::|....|:: :.:.||||||::.||
  Fly   131 NGEEFAIEYGTGSLSGFLSNDIVTIA-GISIQNQTFGEALSEPGTTFVD-APFAGILGLAFSAIA 193

Human   189 RPDDSLEPFFDSLVKQTHVPN-LFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYT 252
              .|.:.|.||:::.|..:.. :.|..|...|        .|..||.:|:||||.|||.|||.|.
  Fly   194 --VDGVTPPFDNMISQGLLDEPVISFYLKRQG--------TAVRGGELILGGIDSSLYRGSLTYV 248

Human   253 PIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEK 317
            |:....|::..:..::.||..|...|      ::|.|:||:.:.:|...:....:.:.|..:.
  Fly   249 PVSVPAYWQFKVNTIKTNGTLLCNGC------QAIADTGTSLIAVPLAAYRKINRQLGATDND-- 305

Human   318 FPDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCY 381
                   ||..| |.:..:     .|.::|.:.|.|      .|:.|:.|:  |:.....|..|.
  Fly   306 -------GEAFVRCGRVSS-----LPKVNLNIGGTV------FTLAPRDYI--VKVTQNGQTYCM 350

Human   382 K-FAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 416
            . |...:..:..::|.|.:..||.|||:..:|||||
  Fly   351 SAFTYMEGLSFWILGDVFIGKFYTVFDKGNERIGFA 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BACE1	NP_036236.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..58
		beta_secretase_like	72..437	CDD:133140	103/354 (29%)
		Interaction with RTN3	479..501
		DXXLL. /evidence=ECO:0000269\|PubMed:15886016	496..500
CG17134	NP_609458.1	pepsin_retropepsin_like	70..386	CDD:299705	101/355 (28%)
CG17134	NP_609458.1	Asp	75..388	CDD:278455	103/352 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151464
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740