DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BACE1 and CG6508

DIOPT Version :9

Sequence 1:	NP_036236.1	Gene:	BACE1 / 23621	HGNCID:	933	Length:	501	Species:	Homo sapiens
Sequence 2:	NP_609457.1	Gene:	CG6508 / 34493	FlyBaseID:	FBgn0032303	Length:	423	Species:	Drosophila melanogaster

Alignment Length:	371	Identity:	104/371 - (28%)
Similarity:	167/371 - (45%)	Gaps:	62/371 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL-----------HRYYQRQLSSTYRDLRKGV 128
            |.:.:.:|:|||..|:..|||||:..|     |.:           |..|....||::.:..||.
  Fly    74 YTIRLCIGTPPQCFNLQFDTGSSDLWV-----PSVKCSSTNEACQKHNKYNSSASSSHVEDGKGF 133

Human   129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDS 193
            .:.|..|...|.|.||.|.| .|..:..:....||.|....|:| :.::||:|:|:|.|:   ..
  Fly   134 SIQYGSGSLSGFLSTDTVDI-DGMVIRNQTFAEAIDEPGSAFVN-TIFDGIIGMAFASIS---GG 193

Human   194 LEPFFDSLVKQTHVPN-LFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRRE 257
            :...||::::|..|.: :||:.|...|  .:||      ||.:|.||||.|:|.|.:.|.|:...
  Fly   194 VTTPFDNIIRQGLVKHPVFSVYLRRDG--TSQS------GGEVIWGGIDRSIYRGCINYVPVSMP 250

Human   258 WYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKA--ASSTEKFPD 320
            .|::.....|:|.|..|...|      ::|.|:||:.:.:|.:.::|..|.:.|  |...|.|.|
  Fly   251 AYWQFTANSVKIEGILLCNGC------QAIADTGTSLIAVPLRAYKAINKVLNATDAGDGEAFVD 309

Human   321 GFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYK-FA 384
            ...|..              .|.::|.:.|..      .|:.|:.|:..|: ...:|..|.. |.
  Fly   310 CSSLCR--------------LPNVNLNIGGTT------YTLTPKDYIYKVQ-ADNNQTLCLSGFT 353

Human   385 ISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAA 430
            ..|.:...::|.:.:...|.|||..::|||||  ....|..:|..|
  Fly   354 YLQGNLLWILGDIFLGKVYTVFDVGKERIGFA--KLKKHSSYRVYA 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BACE1	NP_036236.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..58
		beta_secretase_like	72..437	CDD:133140	104/371 (28%)
		Interaction with RTN3	479..501
		DXXLL. /evidence=ECO:0000269\|PubMed:15886016	496..500
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:299705	101/358 (28%)
CG6508	NP_609457.1	Asp	73..387	CDD:278455	101/359 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151466
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4239
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.690