DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BACE1 and CG33128

DIOPT Version :9

Sequence 1:	NP_036236.1	Gene:	BACE1 / 23621	HGNCID:	933	Length:	501	Species:	Homo sapiens
Sequence 2:	NP_787961.1	Gene:	CG33128 / 326263	FlyBaseID:	FBgn0053128	Length:	405	Species:	Drosophila melanogaster

Alignment Length:	404	Identity:	96/404 - (23%)
Similarity:	165/404 - (40%)	Gaps:	77/404 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    36 GAPL------GLRLPRET--DEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILV 92
            |.|:      |...|.:|  |...||.|             ......||..:.:|:|.|...::.
  Fly    59 GVPIYMQPDYGYDYPSQTSVDYTSEELG-------------NSMNMYYYGLIGIGTPEQYFKVVF 110

Human    93 DTGSSNFAVGAAPHPFL------HRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHG 151
            ||||:|..|.:|.....      |..|....|||:....:...:.|..|...|.|..|.|:| :|
  Fly   111 DTGSANLWVPSAQCLATDVACQQHNQYNSSASSTFVSSGQNFSIQYGTGSVSGYLAIDTVTI-NG 174

Human   152 PNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPN-LFSLQL 215
            ..:..:....|:::....|.:.: ::||||:.|.:||  :|::.|.|.:|.::..:.. :|...|
  Fly   175 LAIANQTFGEAVSQPGASFTDVA-FDGILGMGYQQIA--EDNVVPPFYNLYEEGLIDEPVFGFYL 236

Human   216 CGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKE 280
            ...|..::        ||.:.:||.|.:|..|.:.|||:.::.|::..:..:..||..:...|
  Fly   237 ARNGSAVD--------GGQLTLGGTDQNLIAGEMTYTPVTQQGYWQFAVNNITWNGTVISSGC-- 291

Human   281 YNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLV-CWQAGTTPWNIFPVI 344
                ::|.|:||:.:..|...:......|......         |:..| |....:     .||:
  Fly   292 ----QAIADTGTSLIAAPSAAYIQLNNLIGGVPIQ---------GDYYVPCSTVSS-----LPVL 338

Human   345 SLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQ-SSTGT---VMGAVIMEGFYVV 405
            ::.:.|  ||          .||.|...:.|..:..|...:|. :..||   ::|.|.:..:|..
  Fly   339 TINIGG--TN----------FYLPPSVYIQTYTEGNYTTCMSTFTDIGTGFWILGDVFLGQYYSE 391

Human   406 FDRARKRIGFAVSA 419
            ||..:.|:|||..|
  Fly   392 FDFGQNRVGFATLA 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BACE1	NP_036236.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..58		7/26 (27%)
		beta_secretase_like	72..437	CDD:133140	87/360 (24%)
		Interaction with RTN3	479..501
		DXXLL. /evidence=ECO:0000269\|PubMed:15886016	496..500
CG33128	NP_787961.1	pepsin_retropepsin_like	83..403	CDD:299705	88/376 (23%)
CG33128	NP_787961.1	Asp	92..404	CDD:278455	86/355 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151465
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740