DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BACE1 and CG31928

DIOPT Version :9

Sequence 1:	NP_036236.1	Gene:	BACE1 / 23621	HGNCID:	933	Length:	501	Species:	Homo sapiens
Sequence 2:	NP_001259869.1	Gene:	CG31928 / 326175	FlyBaseID:	FBgn0051928	Length:	418	Species:	Drosophila melanogaster

Alignment Length:	371	Identity:	92/371 - (24%)
Similarity:	159/371 - (42%)	Gaps:	56/371 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    65 DNLRGKSGQGYYVEMTVGSP-PQTLNILVDTGSSNFAVGAAP-------HPFLHRYYQRQLSSTY 121
            :||.......|||....|:| .|.:.:||||.|:|..|.::.       |   |..|....|.||
  Fly    82 ENLINSHNTEYYVTAGFGTPKSQPVTLLVDTASANLLVYSSEFVKQSCLH---HDGYNSSESQTY 143

Human   122 RDLRKGVYVPY-TQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYA 185
            :.......:.: :|....|.|.||..::  |..|......|.|..:.......||::||:||.::
  Fly   144 QANGSPFQIQFASQEILTGILSTDTFTL--GDLVIKNQTFAEINSAPTDMCKRSNFDGIIGLGFS 206

Human   186 EIARPDDSLEPFFDSLVKQTHVPN-LFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSL 249
            |||.  :.:|...|::::|..:.. :|||.       :|::...||.||.:::||.|.:||:|.|
  Fly   207 EIAL--NGVETPLDNILEQGLIDEPIFSLY-------VNRNASDASNGGVLLLGGSDPTLYSGCL 262

Human   250 WYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASS 314
            .|.|:.:..::::.:.:|||..:.|..:|      ::|.|.||:.:.:|....:...|.:....:
  Fly   263 TYVPVSKVGFWQITVGQVEIGSKKLCSNC------QAIFDMGTSLIIVPCPALKIINKKLGIKET 321

Human   315 TEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFR-ITILPQQYLRPVEDVA---- 374
            ..|  ||.::   :.|.:....|..:|            |..:: .|:.|..|:.......
  Fly   322 DRK--DGVYI---IDCKKVSHLPKIVF------------NIGWKDFTLNPSDYILNYSGTCVSGF 369

Human   375 TSQDDCYKFAISQSSTGT----VMGAVIMEGFYVVFDRARKRIGFA 416
            :|..||.....:..|...    |.|.|.....:.:||...|.:|.|
  Fly   370 SSLSDCNGTQTNDDSEDLNNIWVFGDVFFGAIFTLFDFGLKLVGMA 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BACE1	NP_036236.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..58
		beta_secretase_like	72..437	CDD:133140	90/364 (25%)
		Interaction with RTN3	479..501
		DXXLL. /evidence=ECO:0000269\|PubMed:15886016	496..500
CG31928	NP_001259869.1	pepsin_retropepsin_like	84..416	CDD:299705	91/369 (25%)
CG31928	NP_001259869.1	Asp	91..416	CDD:278455	90/362 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4239
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760