DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BACE1 and Pgcl

DIOPT Version :9

Sequence 1:	NP_036236.1	Gene:	BACE1 / 23621	HGNCID:	933	Length:	501	Species:	Homo sapiens
Sequence 2:	NP_525030.1	Gene:	Pgcl / 30984	FlyBaseID:	FBgn0011822	Length:	407	Species:	Drosophila melanogaster

Alignment Length:	368	Identity:	87/368 - (23%)
Similarity:	153/368 - (41%)	Gaps:	79/368 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    65 DNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF------AVGAAPHPFLHRYYQRQLSSTYRD 123
            ||.:      ||..:::|:|.|...:..||||||.      .:..|...  |:.:.:..||||..
  Fly    73 DNFQ------YYGNISIGTPGQDFLVQFDTGSSNLWVPGSSCISTACQD--HQVFYKNKSSTYVA 129

Human   124 LRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANI--AAITESDKFFINGSNWEGILGLAYAE 186
            ......:.|..|...|.|..|.|..   ..:|:::..  ...||....|:: :.::||||:.:..
  Fly   130 NGTAFSITYGTGSVSGYLSVDCVGF---AGLTIQSQTFGEVTTEQGTNFVD-AYFDGILGMGFPS 190

Human   187 IARPDDSLEPFFDSLVKQTHVPN-LFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLW 250
            :|  .|.:.|.|.::::|..|.: :||       |.|..:..:...||.:|:||.|.|||:|||.
  Fly   191 LA--VDGVTPTFQNMMQQGLVQSPVFS-------FFLRDNGSVTFYGGELILGGSDPSLYSGSLT 246

Human   251 YTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPK-------KVFEAAVKS 308
            |..:.:..|::.....:::....:.      .:.::|.|:||:.:..|:       ::|.|..:.
  Fly   247 YVNVVQAAYWKFQTDYIKVGSTSIS------TFAQAIADTGTSLIIAPQAQYDQISQLFNANSEG 305

Human   309 IKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDV 373
            :...||| .:||                           |:..:....|:|   |.:|.     :
  Fly   306 LFECSST-SYPD---------------------------LIININGVDFKI---PAKYY-----I 334

Human   374 ATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 416
            ...:|.|.....|.:....:||.|.:...|..||...:|:|||
  Fly   335 IEEEDFCSLAIQSINQDFWIMGDVFLGRIYTEFDVGNQRLGFA 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BACE1	NP_036236.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..58
		beta_secretase_like	72..437	CDD:133140	85/361 (24%)
		Interaction with RTN3	479..501
		DXXLL. /evidence=ECO:0000269\|PubMed:15886016	496..500
Pgcl	NP_525030.1	pepsin_retropepsin_like	67..378	CDD:299705	87/368 (24%)
Pgcl	NP_525030.1	Asp	76..379	CDD:278455	85/365 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810