DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NTSR2 and ntsr1

DIOPT Version :9

Sequence 1:	NP_036476.2	Gene:	NTSR2 / 23620	HGNCID:	8040	Length:	410	Species:	Homo sapiens
Sequence 2:	XP_021329279.1	Gene:	ntsr1 / 569344	ZFINID:	ZDB-GENE-090313-372	Length:	400	Species:	Danio rerio

Alignment Length:	370	Identity:	145/370 - (39%)
Similarity:	230/370 - (62%)	Gaps:	43/370 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    23 LGVDTRLWAKVLFTALYALIWALGAAGNALSAHVVL--KARAGRAGRLRHHVLSLALAGLLLLLV 85
            |.|:|.:::|||.|.:|.:::.:|..||:::.:.:|  |:.......:.:|:.|||::.||:|::
Zfish    44 LDVNTDIYSKVLVTVIYVVLFLIGCLGNSITLYTLLTKKSLQNLQSTVHYHLASLAISDLLILVL 108

Human    86 GVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPR 150
            .:|:|||:|:|.|:||.||:..|:||||:.:.|:|||..::|.||.||.:|:|.|.:|:|:::..
Zfish   109 CMPIELYNFIWVHHPWAFGEAVCKGYYFLRDGCSYATAFNIASLSVERFMAICHPFKAKSIMSRS 173

Human   151 RTRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSF 215
            ||:.|::..|.||..||.||...|||    :..:.|     .:||.:||....:..:|:|..:||
Zfish   174 RTKKLISAMWIASFFLATPMLFTMGQ----QLMNDE-----YICTTIVSSITAKTVLQLNAFLSF 229

Human   216 VLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSL 280
            |:|:||.:.||||..|.||.:..:        |:..:|:.::                 ||..::
Zfish   230 VVPMALISALNGVIASQLLRMFRE--------SAQDNRVCII-----------------GGNATM 269

Human   281 VR-HKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTN 344
            :. ..:..|.:|::..|.||||:|:.:|:|||||||||||||||.:  ||..||:||||||||||
Zfish   270 LSVAVEPNRAQSMRHGVMVLRAVVIAFVVCWLPYHARRLMYCYVTE--WTTALYDFYHYFYMVTN 332

Human   345 TLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSL---CGEHHPMKRL 386
            .|||||||:.|:|||.||:::|::|...:..|   | .|...||:
Zfish   333 VLFYVSSAINPILYNLVSANYRQIFFSTLRYLILPC-RHKKQKRV 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NTSR2	NP_036476.2	7tmA_NTSR2	33..369	CDD:320478	135/338 (40%)
		TM helix 1	33..60	CDD:320478	8/28 (29%)
		TM helix 2	68..94	CDD:320478	11/25 (44%)
		TM helix 3	108..138	CDD:320478	15/29 (52%)
		TM helix 4	152..170	CDD:320478	7/17 (41%)
		TM helix 5	203..232	CDD:320478	12/28 (43%)
		TM helix 6	290..320	CDD:320478	18/29 (62%)
		TM helix 7	337..362	CDD:320478	19/24 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..410		2/6 (33%)
ntsr1	XP_021329279.1	7tmA_NTSR1	54..357	CDD:320477	135/338 (40%)
		TM helix 1	54..81	CDD:320477	8/26 (31%)
		TM helix 2	91..117	CDD:320477	11/25 (44%)
		TM helix 3	131..161	CDD:320477	15/29 (52%)
		TM helix 4	173..195	CDD:320477	10/21 (48%)
		TM helix 5	217..246	CDD:320477	12/28 (43%)
		TM helix 6	280..310	CDD:320477	18/29 (62%)
		TM helix 7	325..350	CDD:320477	19/24 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BJWF
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D225435at7742
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.880