DRSC/TRiP Functional Genomics Resources

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Protein Alignment NTSR2 and PK2-R2

DIOPT Version :9

Sequence 1:NP_036476.2 Gene:NTSR2 / 23620 HGNCID:8040 Length:410 Species:Homo sapiens
Sequence 2:NP_731788.1 Gene:PK2-R2 / 41638 FlyBaseID:FBgn0038139 Length:599 Species:Drosophila melanogaster


Alignment Length:403 Identity:95/403 - (23%)
Similarity:157/403 - (38%) Gaps:135/403 - (33%)


- Green bases have known domain annotations that are detailed below.


Human     1 METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSAHVVLKARAGRA 65
            :.|.:|..|       |||.|.|.|.            ||||:..|..||.::..|:.:      
  Fly    54 LPTVTPMTP-------LSLLATLSVG------------YALIFIAGVLGNLITCIVISR------ 93

Human    66 GRLRH-----HVLSLALAGLLLLLVGVPVELYSFVWF--HYPWVFGDLGCRGYYFVHELCAYATV 123
            ....|     ::.:||::.::||..|:|.:||: :|.  :||  |.|..|.....:.|..|.|||
  Fly    94 NNFMHTATNFYLFNLAISDMILLCSGMPQDLYN-LWHPDNYP--FSDSICILESVLSETAANATV 155

Human   124 LSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEPE 188
            |::...:.||.:|:|.|.|..::....|....:...|.|:|.||||.|                 
  Fly   156 LTITAFTVERYIAICHPFRQHTMSKLSRAVKFIFAIWIAALLLALPQA----------------- 203

Human   189 PASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSR 253
                              ||.:|::.   .:..:..:.....:|:.|:                 
  Fly   204 ------------------IQFSVVMQ---GMGTSCTMKNDFFAHVFAV----------------- 230

Human   254 LELLSEEGLLSFIVWKKTFIQGGQVSLV----------------------RHKDVRR-IRSLQRS 295
                  .|.|.|         ||.::.:                      |..||.| |.:..|.
  Fly   231 ------SGFLFF---------GGPMTAICVLYVLIGVKLKRSRLLQALPRRCYDVNRGISAQTRV 280

Human   296 VQVLRAIVVMYVICWLPYHARRLMYCYVP----DDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPL 356
            :::|.|:.|.:.|||.|:||:|||..|..    :..|.:.:::...|   .:..|:::|:.:.||
  Fly   281 IRMLVAVAVAFFICWAPFHAQRLMAVYGSTSGIESQWFNDVFSILDY---TSGVLYFLSTCINPL 342

Human   357 LYNAVSSSFRKLF 369
            |||.:|..||:.|
  Fly   343 LYNIMSHKFREAF 355

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NTSR2NP_036476.2 7tmA_NTSR2 33..369 CDD:320478 85/369 (23%)
TM helix 1 33..60 CDD:320478 8/26 (31%)
TM helix 2 68..94 CDD:320478 9/30 (30%)
TM helix 3 108..138 CDD:320478 10/29 (34%)
TM helix 4 152..170 CDD:320478 6/17 (35%)
TM helix 5 203..232 CDD:320478 3/28 (11%)
TM helix 6 290..320 CDD:320478 12/29 (41%)
TM helix 7 337..362 CDD:320478 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 381..410
PK2-R2NP_731788.1 7tm_1 83..344 CDD:278431 74/342 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D380940at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24243
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
33.020

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