Protein Alignment TSSK2 and Sik3

DIOPT Version :10

• Sequence 1: NP_443732.3
• Gene: TSSK2 / 23617
• HGNCID: 11401
• Length: 358
• Species: Homo sapiens
• Sequence 2: NP_611361.4
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Alignment Length: 370
• Identity: 126/370 - (34%)
• Similarity: 185/370 - (50%)
• Gaps: 39/370 - (10%)

Human     6 VLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHG 70
            :||...|.:...:|||::|.||.|.:...|..||:||||:.....:::.:.. ||:.||.::.|.
  Fly    35 LLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTF-REIAILKSLRHP 98

Human    71 SIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHR 135
            .|.:.||:.| |...||::.|....|::.:.:...|.:.|..|.::|.||.|||.|||...:|||
  Fly    99 HITRLYEVME-SQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHR 162

Human   136 DLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIW 200
            |||.||:|||||.||||:|||||...   ..|..:  ||:|||..||||||.|.:.|.....|||
  Fly   163 DLKAENVLLDKDMNIKLADFGFSNHY---EEGATL--KTWCGSPPYAAPEVFQGLEYDGPKSDIW 222

Human   201 SLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQPDVSQRLHI 263
            ||||:||.:|||::|:|...|.::..  :..:.|:.|..|:    ||:.||..||..:..:|..|
  Fly   223 SLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQ----ECEQLIRNMLVVEPDRRYTI 283

Human   264 DEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLDTKT-GLRPDHRPDHKLGAKTQHRLLVVP 327
            .:|:.|.||...:.:......|.....|.........|.: |...|..|  :|.:.....:|.:|
  Fly   284 KQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDSPP--QLDSVVMTHMLQLP 346

Human   328 ----------------EN----ENRMEDRLAETSRAK---DHHIS 349
                            :|    .|.:.|:|.:..|..   .||.|
  Fly   347 GLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHAS 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TSSK2	NP_443732.3	STKc_TSSK1_2-like	10..272	CDD:271067	105/263 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	302..358		14/72 (19%)
Sik3	NP_611361.4	Protein Kinases, catalytic domain	40..292	CDD:473864	105/262 (40%)
		UBA_SIK	335..380	CDD:270523	6/44 (14%)