DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TSSK2 and par-1

DIOPT Version :9

Sequence 1:	NP_443732.3	Gene:	TSSK2 / 23617	HGNCID:	11401	Length:	358	Species:	Homo sapiens
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	343	Identity:	115/343 - (33%)
Similarity:	186/343 - (54%)	Gaps:	37/343 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    18 LGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYEIFETS 82
            :|||::||||.|........||:||||:.:.....::: |.||:.|:..::|.:|:|.:::.||
  Fly   259 IGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQK-LFREVRIMKMLDHPNIVKLFQVIET- 321

Human    83 DGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKD 147
            :..:|:|||....|::.:::...|.:.|..||..|||:.|||:|||...|:|||||.||||||.:
  Fly   322 EKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSE 386

Human   148 FNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCG 212
            .|||::|||||......|.     ..|||||..|||||:.|...|.....|:||||||||.:|.|
  Fly   387 LNIKIADFGFSNEFTPGSK-----LDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSG 446

Human   213 SMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPP 275
            |:|:|.|.:|::..  ::.::|:.|    .::.:|::|:.:.|..:.::|..::.|:...|:
  Fly   447 SLPFDGSTLRELRERVLRGKYRIPF----YMSTDCENLLRKFLVLNPAKRASLETIMGDKWM--- 504

Human   276 KPKATSSASFKREGEGKYRAECKLDTKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAET 340
                  :..|: |.|.|...|.|.|.             ...|....|:.:..|.:.:|..|::.
  Fly   505 ------NMGFE-EDELKPYIEPKADL-------------ADPKRIEALVAMGYNRSEIEASLSQV 549

Human   341 SRAKDHHISGAEVGKAST 358
             |..|...:...:|:.||
  Fly   550 -RYDDVFATYLLLGRKST 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TSSK2	NP_443732.3	STKc_TSSK1_2-like	10..272	CDD:271067	97/255 (38%)
		S_TKc	12..272	CDD:214567	97/255 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..358		8/55 (15%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	97/255 (38%)
		S_TKc	253..504	CDD:214567	97/255 (38%)
		UBA_MARK_Par1	525..563	CDD:270522	7/38 (18%)
		MARK1-3_C	839..936	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910