Protein Alignment ZMYND8 and zmynd8

DIOPT Version :10

• Sequence 1: NP_001350643.1
• Gene: ZMYND8 / 23613
• HGNCID: 9397
• Length: 1241
• Species: Homo sapiens
• Sequence 2: XP_068080416.1
• Gene: zmynd8 / 564460
• ZFINID: ZDB-GENE-041119-1
• Length: 1205
• Species: Danio rerio
• Alignment Length: 1222
• Identity: 808/1222 - (66%)
• Similarity: 948/1222 - (77%)
• Gaps: 104/1222 - (8%)

Human     4 LEEFEARSCLAEEEIKTEQEVVEGMDISTRSK--DPGSAERTAQKRKFPSPPHSSNGHSPQDTST 66
            :.|.:....||..|.| |.|..|||:|:||||  |.||.|||..|||..|||||||||||.::|.
Zfish     1 MTELQIWLSLAGGEGK-ESEATEGMEIATRSKVSDQGSTERTVPKRKVSSPPHSSNGHSPSESSP 64

Human    67 SPIKKKKKPGLLNSNNKEQSELRHGPFYYMKQP-LTTDPVDVVPQDGRNDFYCWVCHREGQVLCC 130
            ||:|||||||.:|| :|:|||||||||||:||| |||||||||||||||||||||||||||||||
Zfish    65 SPVKKKKKPGAVNS-SKDQSELRHGPFYYVKQPALTTDPVDVVPQDGRNDFYCWVCHREGQVLCC 128

Human   131 ELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQP 195
            ||||||||||||:|.:|||||||||||||||||||||||||||||||::|||:|||||:||||||
Zfish   129 ELCPRVYHAKCLKLAAEPEGDWFCPECEKITVAECIETQSKAMTMLTLDQLSFLLKFALQKMKQP 193

Human   196 GTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHK 260
            ||:.|||||.|||||||||||||.||:||||||.||||||.|||||||.||||||||||||||||
Zfish   194 GTEPFQKPVSLEQHPDYAEYIFHAMDICTLEKNIKKKMYGSTEAFLADVKWILHNCIIYNGGNHK 258

Human   261 LTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRD 325
            ||..|||::||||||||||||||||||:|||||||||||||||||||||||||||||||||||||
Zfish   259 LTATAKVIVKICEHEMNEIEVCPECYLSACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRD 323

Human   326 KDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYS 390
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||:
Zfish   324 KDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRKKFGVFNYA 388

Human   391 PFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLS--GGTGRRISL 453
            ||||||||::|:||||||.|||||:.|.:||||:|.|||:|||||:|:.|.::|  .|||||||:
Zfish   389 PFRTPYTPDNQFQMLLDPANPSAGSVKPEKQEKIKFNFDVTASPKLLVGKSMVSSGSGTGRRISM 453

Human   454 SDMPRSPMSTNSSVHTGSDVEQD-AEK---KATSSHFSASEESMDFLDKSTASPASTKTGQAGSL 514
            :||||||||||||.|||||.||: |||   ||...|:|..|||.|    .||||||::   |||.
Zfish   454 TDMPRSPMSTNSSAHTGSDGEQETAEKGHAKAALPHYSTGEESQD----CTASPASSR---AGST 511

Human   515 SGSPKPF-SPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVP-LISPKR 577
            ..||||| ||..:.|:  |.:||.|||||||||||||||||||||||||||||....| |.||||
Zfish   512 LESPKPFHSPAPNTPV--KQEKTPTTGSILNLNLDRSKAEMDLKELSESVQQQQGAQPSLTSPKR 574

Human   578 QIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPE 642
            |||||||||||||||||||||||:|||||||..|||||||:|:|||||||||.|:|||||||...
Zfish   575 QIRSRFQLNLDKTIESCKAQLGIDEISEDVYKGVEHSDSEESDKSDSSDSEYGSEDEQKSKNGQN 639

Human   643 D---TEDKEGCQMDKEPSAVKKKPKPT----NPVEIKEELKSTSPASEKADPG--------AVKD 692
            :   .|||:    :|||.  |||.||:    ...:..:|..:|:....||:.|        ..||
Zfish   640 NKTTAEDKK----EKEPP--KKKSKPSAAAGEDKDTSKESSATASTKAKAETGQKTSTPDLIAKD 698

Human   693 KASPEPEKDFSEKAK--PSPHPIKDKLKGKDETDSP-TVHLGLDSDSESELVIDLGEDHSGREGR 754
            |:..:.||:..||.|  |:....::|.|..:|...| :|.:.:|||||.||||||||:.:|:|.:
Zfish   699 KSGMDSEKEPPEKLKAAPASPDAREKGKSSEEASQPASVDVDMDSDSERELVIDLGEEQAGKERK 763

Human   755 KNKKEP------KEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRS-----SAQTSAA-------- 800
            :::|:.      |||:..:. .|||.|.|:  |.:.|:..||:.|     .:|:..|
Zfish   764 RSRKDSAAVTALKEPTASKS-EGKTTPITS--SLTQPQNTVLSSSPTMKDPSQSPMAVPLNIIPL 825

Human   801 -GATATTS-TSSTVTVTAPAPAATGSP-----VKKQRPLLPKETAPAVQR-VVWNSSSKFQTSSQ 857
             ||.::|| ||||:.::..:.|::.||     |||||||||:||.|.||: ||||.|:|||||||
Zfish   826 TGAASSTSLTSSTLPISTASTASSSSPINTSTVKKQRPLLPRETVPVVQQAVVWNPSTKFQTSSQ 890

Human   858 KWHMQKMQRQQQQQQQ------------QNQQQQ-----------PQSSQGTRYQTRQAVKAVQQ 899
            ||||||:|||||.|.|            :|||.|           .|:|..|||||||::|.  |
Zfish   891 KWHMQKVQRQQQGQTQPATQAQVLTQVERNQQPQQQAQVSSSSSGQQASSSTRYQTRQSMKV--Q 953

Human   900 KEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNA-DLPIATASADVAADIAKYTSKMMDA 963
            |:.:.:.|||.:||||||..|..:.:..::|:..:|..| |..|.|.||||||||||||:|:|||
Zfish   954 KDSSHTTSTSAVTLVTSTPVSATIMAGSTVSSSSTSATAGDFQIPTTSADVAADIAKYTNKIMDA 1018

Human   964 IKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERD 1028
            |||||.||||||:|:|:|:|||||||||||||||||||||||||||||||||||||||||||||:
Zfish  1019 IKGTMNEIYNDLTKSTSGNTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERE 1083

Human  1029 RLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSA 1093
            |::||||||:|:||||||||||||||||||:||||||||||||||||||||||||||||||||||
Zfish  1084 RIVAEVKKQMEMEKQQAVDETKKKQWCANCRKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSA 1148

Human  1094 TAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASAS-KEKETSAEKSKES 1144
            |:.|||.::|.:|:...| :.|..::..::|.||.|:: .:|::..:|:|::
Zfish  1149 TSSQQEQESEGSTDVTPK-APGQPNNGPNSPRETVSSTPADKDSEVDKAKDN 1199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZMYND8	NP_001350643.1	TNG2	<31..160	CDD:227367	107/131 (82%)
		PHD_PRKCBP1	117..157	CDD:277013	36/39 (92%)
		Bromo_RACK7	178..276	CDD:99940	81/97 (84%)
		PWWP_PRKCBP1	299..389	CDD:438988	88/89 (99%)
		DUF3544	449..647	CDD:463452	145/206 (70%)
		TFIIF_alpha	<629..>787	CDD:310411	65/181 (36%)
		AtpF	<984..>1051	CDD:440475	61/66 (92%)
		zf-MYND	1055..1089	CDD:460312	32/33 (97%)
zmynd8	XP_068080416.1	TNG2	<15..158	CDD:227367	114/144 (79%)
		PHD_PRKCBP1	115..155	CDD:277013	36/39 (92%)
		Bromo_RACK7	176..274	CDD:99940	81/97 (84%)
		PWWP_PRKCBP1	297..387	CDD:438988	88/89 (99%)
		DUF3544	449..644	CDD:463452	144/203 (71%)
		AtpF	<1037..>1106	CDD:440475	62/68 (91%)
		zf-MYND	1110..1144	CDD:460312	32/33 (97%)