DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CD2AP and Abl

DIOPT Version :10

Sequence 1:NP_036252.1 Gene:CD2AP / 23607 HGNCID:14258 Length:639 Species:Homo sapiens
Sequence 2:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster


Alignment Length:542 Identity:109/542 - (20%)
Similarity:176/542 - (32%) Gaps:196/542 - (36%)


- Green bases have known domain annotations that are detailed below.


Human   133 DIIDINEEVEEGWWSGTLNNKLGL----------------FPSNFVKELEVT-------DDGETH 174
            |:.:|...|||.      :::.|:                .|...:||..:|       |.....
  Fly  1219 DVSNIAPSVEEA------SSRFGVSLRKREPSTDSCSSLGSPPEDLKEKLITEIKAAGKDTAPAS 1277

Human   175 EAQDDSETVLAGPTS--------------PIP----SLGNVSETASGSVTQPKKIRGIGFGDIFK 221
            ...:.|...:..|.|              |.|    .|.|.:.|.||...|.||:..       |
  Fly  1278 HLANGSGIAVVDPVSLLVTELAESMNLPKPPPQQQQKLTNGNSTGSGFKAQLKKVEP-------K 1335

Human   222 EGSVKLRTRTSSSET------------EEKKPEKPLILQSLGPKTQSVEITKT---DTEGKIKAK 271
            :.|..: .:...:.|            :||:|..|      .|...:|.:...   :|.|.:..|
  Fly  1336 KMSAPM-PKAEPANTIIDFKAHLRRVDKEKEPATP------APAPATVAVANNANCNTTGTLNRK 1393

Human   272 EYCRTLFAYEGTNEDELTFKEGEI-IHL----ISKETGEAGWWRGELNGKEGVFPDNFAVQINEL 331
            |        :|:.:.....::.|| |.:    :..:.|.||  .|:|..:..      ...||.|
  Fly  1394 E--------DGSKKFSQAMQKTEIKIDVTNSNVEADAGAAG--EGDLGKRRS------TGSINSL 1442

Human   332 DKDFPKPKKPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPS------KPAAPQVPPK 390
            .|.:  .::||.|..|.:                       :.|:|:||      .|.| |:.||
  Fly  1443 KKLW--EQQPPAPDYATS-----------------------TILQQQPSVVNGGGTPNA-QLSPK 1481

Human   391 KPTPPTKASNLLRSSGTVYPK-----RPEKPVPPPPPIAKINGEVSSISSKFETEPVSKLKLDSE 450
            .    ...|..:.:.||:..|     .|..|.||||.....|...:|||:            .|.
  Fly  1482 Y----GMKSGAINTVGTLPAKLGNKQPPAAPPPPPPNCTTSNSSTTSIST------------SSR 1530

Human   451 QLPLRPKSVDFDSLTVRTSKETDVVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTHSP 515
            ....|.::    |.|::||..|.:...|:..|                 ...|..:||       
  Fly  1531 DCTSRQQA----SSTIKTSHSTQLFTDDEEQS-----------------HTEGLGSGG------- 1567

Human   516 EKILKLPKEEDSANLKPSELKKDTCYSPKPSVYLSTPSSASKANTTAFLTPLEIKAKVETDDVKK 580
                     :.||::..|..::......||:|    |...:|  .|.:.||:   ||:.......
  Fly  1568 ---------QGSADMTQSLYEQKPQIQQKPAV----PHKPTK--LTIYATPI---AKLTEPASSA 1614

Human   581 NSLDELRAQIIELLCIVEALKK 602
            :|....|..|:||:.::|...|
  Fly  1615 SSTQISRESILELVGLLEGSLK 1636

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CD2APNP_036252.1 Interaction with ANLN and localization to the midbody. /evidence=ECO:0000269|PubMed:15800069 1..175 11/64 (17%)
SH3_CD2AP_1 3..58 CDD:212986
SH3_CD2AP_2 111..165 CDD:212987 8/47 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 168..209 13/65 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 227..256 6/40 (15%)
SH3_CD2AP_3 271..327 CDD:212989 11/60 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 333..428 24/105 (23%)
SH3-binding. /evidence=ECO:0000255 336..352 4/15 (27%)
SH3-binding. /evidence=ECO:0000255 378..397 7/24 (29%)
SH3-binding. /evidence=ECO:0000255 410..422 6/16 (38%)
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784
SH2_ABL 268..363 CDD:198189
PTKc_Abl 382..644 CDD:270645
FABD 1584..1723 CDD:197885 17/62 (27%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.