DRSC/TRiP Functional Genomics Resources

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Protein Alignment CD2AP and Src42A

DIOPT Version :10

Sequence 1:NP_036252.1 Gene:CD2AP / 23607 HGNCID:14258 Length:639 Species:Homo sapiens
Sequence 2:NP_001400996.1 Gene:Src42A / 35524 FlyBaseID:FBgn0264959 Length:1606 Species:Drosophila melanogaster


Alignment Length:562 Identity:124/562 - (22%)
Similarity:189/562 - (33%) Gaps:180/562 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    68 LPIKRERHGNVASLVQR--ISTYG-LPAGGIQPHPQTKN-IKKKTKKRQC-----KVLFEYIPQN 123
            ||:.|....:::|...|  ...|. |..|.|....|.|| |.:|..|...     ::|.....|:
  Fly   779 LPLHRSNTSDISSSYYRRNFKIYDKLVYGTIYDIIQRKNDIYQKYDKYMTYGTIYEILHRKTSQS 843

Human   124 EDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPT 188
            .|..:.|     .::..:|.|..||.:                :.|.|:..|.  |..|      
  Fly   844 SDPWQRK-----SLSSILEGGRSSGDI----------------IYDIGQRRER--DKRT------ 879

Human   189 SPIPSLGNVSETASGSVTQPKKIRGIGFGDIF--------KEGSVKLRTRTSSSETEE--KKPEK 243
                 ||: |.:|:.|...|.|     :|.|:        ..|.||.:....|..|:.  .||.:
  Fly   880 -----LGS-SSSATVSTINPHK-----YGTIYDILQGVKIDAGHVKNKPDQKSKPTKPPLAKPTR 933

Human   244 PLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLI--SKETGEA 306
            .::.|.:.|    |:|..||..|| ..:|        :|..:.....|...:.:::  |:.:||.
  Fly   934 FVVSQVVEP----VQIPPTDQSGK-SVQE--------QGAPKSNKPNKMRRLSNILSYSRNSGED 985

Human   307 GWWRGELNGKEGVFPDNFAVQINELDKDFPKPKKPPPPAK-------APAPKPEL----IAAEK- 359
               :.|..|||..                 |||:.....:       .|....||    ||.:: 
  Fly   986 ---QQETTGKEET-----------------KPKRTQAKRRIGVTNLLLPLDSEELYTRIIAQQRG 1030

Human   360 --KYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKASNLLRSSGTVYPKRPEKPVPPPP- 421
              |..|.:||||  .::.||..::.|.           ||:|:|...|.:|.......|.||.| 
  Fly  1031 LDKEHSQEPEEK--CASEEQMCTRNAL-----------TKSSSLDAISLSVAISPASSPSPPRPR 1082

Human   422 ---------------PIAK---INGEVSSISSKFETEPVSKLKLDSEQLPLR----PKSVDFDSL 464
                           |:||   ::..:..:||....:|   |:..|.|.||:    |.:.:....
  Fly  1083 RSLKQHRCLQQHQQTPLAKKHSLDNCLQVVSSTTSRQP---LRRWSNQTPLKCTCHPATEELPLT 1144

Human   465 TVRTSKETDVVNFDDIASSENLLHL-------------------TANRPKMPGRRLP----GRFN 506
            .:..|:.....  ...:.|....||                   ||.:.|  .|||.    |.|.
  Fly  1145 AIEKSRSLPAA--CSASCSHTCAHLSVIDQSPATTKCFGKTSLTTAKKGK--SRRLSEFTRGEFL 1205

Human   507 GGHS------PTHSPEKILKLPKEEDSANLKPSELKKDTCYS 542
            ...|      .....||.|.||:.|..|.|......:...||
  Fly  1206 NEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYS 1247

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CD2APNP_036252.1 Interaction with ANLN and localization to the midbody. /evidence=ECO:0000269|PubMed:15800069 1..175 25/115 (22%)
SH3_CD2AP_1 3..58 CDD:212986
SH3_CD2AP_2 111..165 CDD:212987 8/58 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 168..209 10/40 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 227..256 6/30 (20%)
SH3_CD2AP_3 271..327 CDD:212989 10/57 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 333..428 30/127 (24%)
SH3-binding. /evidence=ECO:0000255 336..352 4/22 (18%)
SH3-binding. /evidence=ECO:0000255 378..397 1/18 (6%)
SH3-binding. /evidence=ECO:0000255 410..422 4/27 (15%)
Src42ANP_001400996.1 SH2_Src_Src42 1210..1301 CDD:198233 10/38 (26%)
PTKc_Frk_like 1328..1596 CDD:270653
Blue background indicates that the domain is not in the aligned region.

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