DRSC/TRiP Functional Genomics Resources

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Protein Alignment CD2AP and Btk

DIOPT Version :10

Sequence 1:NP_036252.1 Gene:CD2AP / 23607 HGNCID:14258 Length:639 Species:Homo sapiens
Sequence 2:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster


Alignment Length:292 Identity:63/292 - (21%)
Similarity:93/292 - (31%) Gaps:92/292 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    93 GGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDE---LELKVGDIIDINEEVEEGWW--SGTLNN 152
            ||| |.|.|.|.|.|......|::....|....|   |.|:.....::.::.:|.||  ...|.|
  Fly   325 GGI-PTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGN 388

Human   153 KLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFG 217
             :|..|||:||                 ...|.|.......:|::|...:.|:.:.        |
  Fly   389 -VGYIPSNYVK-----------------PKALLGLERYEWYVGDMSRQRAESLLKQ--------G 427

Human   218 DIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEI------TKTDTEGKIKAKEYCRT 276
            |  |||...:|          |...|.|...||..|.....:      .....|..:..|..|.|
  Fly   428 D--KEGCFVVR----------KSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCET 480

Human   277 ---LFAYE------------------------GTNEDELTFKEGEIIHLISKETGEA-------G 307
               |..|.                        |.:.|:......|:  ::.:|.|..       |
  Fly   481 IPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMEL--MLMEELGSGQFGVVRRG 543

Human   308 WWRGELNG-----KEGVF-PDNFAVQINELDK 333
            .|||.::.     |||.. .|:|..:...:.|
  Fly   544 KWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTK 575

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CD2APNP_036252.1 Interaction with ANLN and localization to the midbody. /evidence=ECO:0000269|PubMed:15800069 1..175 25/86 (29%)
SH3_CD2AP_1 3..58 CDD:212986
SH3_CD2AP_2 111..165 CDD:212987 16/58 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 168..209 5/40 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 227..256 7/28 (25%)
SH3_CD2AP_3 271..327 CDD:212989 19/95 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 333..428 1/1 (100%)
SH3-binding. /evidence=ECO:0000255 336..352
SH3-binding. /evidence=ECO:0000255 378..397
SH3-binding. /evidence=ECO:0000255 410..422
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 15/70 (21%)
SH2_Tec_family 403..505 CDD:198188 22/121 (18%)
PTKc_Tec_like 521..778 CDD:173637 13/57 (23%)
Blue background indicates that the domain is not in the aligned region.

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