DRSC/TRiP Functional Genomics Resources

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Protein Alignment CD2AP and cdap-2

DIOPT Version :10

Sequence 1:NP_036252.1 Gene:CD2AP / 23607 HGNCID:14258 Length:639 Species:Homo sapiens
Sequence 2:NP_491143.3 Gene:cdap-2 / 171906 WormBaseID:WBGene00021549 Length:551 Species:Caenorhabditis elegans


Alignment Length:631 Identity:164/631 - (25%)
Similarity:239/631 - (37%) Gaps:186/631 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    76 GNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKV---LFEYIPQNEDELELKVGDIIDI 137
            |||..:|.|:|...........|.|.:. :....:.|.::   .:.|..:.:|||...|||:|::
 Worm    12 GNVRDIVNRLSRDMTNRNPFTVHQQVER-RAPPPQPQAQIYVATYAYSSKQDDELSFVVGDLIEL 75

Human   138 NEEVEEGWWSGTLNN--KLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSET 200
            ..:||:||..|.|.:  .:|:||:||| .|:.|        ...|...:|...|...|.|:.:.|
 Worm    76 ISDVEDGWSKGKLKSTGAVGMFPTNFV-TLKPT--------PSTSAAAVAPAASASTSAGSAART 131

Human   201 ASGSV-------TQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPK----- 253
            .:.|:       ::||.|                 .||.|:...:..|    :|::|..|     
 Worm   132 PAKSIGSEVVMRSEPKAI-----------------DRTPSTIISDPAP----VLKALETKFSSTF 175

Human   254 TQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGE-IIHLISKETGEAGWWRGELNGKE 317
            ..|.....||.| ..|.||..|..|.|...::|||..||.: :|::.:|..|:|||:.|||:||:
 Worm   176 ASSAASASTDAE-TTKTKEMARVKFVYNPQHDDELALKEIDMLINITNKNCGDAGWFEGELHGKK 239

Human   318 GVFPDNFA--VQI--------------NELDKDFPKPKKPP--PPAKAPAPKPELIAAEKKYFSL 364
            |:|||||.  ||:              .:....|...|.||  ||..|..|||..|         
 Worm   240 GLFPDNFVELVQVPLGTESGARHGSISRQATLTFVSHKPPPVNPPQPAVPPKPAKI--------- 295

Human   365 KPEEKDEKSTLEQKPS--KPAAPQVPPKKPTP--PTKASNLLRSSGTVYPKRPEKPVPPPPPIAK 425
                    |..:..||  .||||..|...|:.  ||..|                  |..|.||.
 Worm   296 --------SVADPPPSTIAPAAPSAPAPAPSQLNPTSTS------------------PTMPAIAP 334

Human   426 INGEVSSISSKF---------ETEPVSKLKLDSEQLPLRPKSVDFDSLTVRTSKETDVVN--FDD 479
            .:   |::.|.|         ..:.|:..|:.|.|   :|...|..|....|:.|..:.|  .|.
 Worm   335 SS---SALKSNFAALQEKMSRNLKVVAPEKVASIQ---KPDQRDRSSTGESTTGEPSIDNSATDQ 393

Human   480 IASSENLLHLTANRPKMP-GRRLPGRFNGGHSPTHSPEKILKLPKEEDSAN------LKPSELKK 537
            :|   .|.|:|.||.:.| .|.:....|...|...||...|..|....:.|      ..|:..|:
 Worm   394 VA---ELQHITKNRARPPKNRPMSMVMNRNRSSDESPNGRLSSPTSISTVNPMSASMFVPATAKE 455

Human   538 -------DTCYSPKPSVYLSTPSSASK----------------ANTTAF-------------LTP 566
                   ....||..|..::.||||||                ::|:|.             |.|
 Worm   456 ISIPSNSSATSSPFKSSSIAPPSSASKPALRPIPSNSLADDSTSSTSAIRKLASPDSQKSPNLPP 520

Human   567 LEIKAKVETDDVKKNSLDELRAQIIELLCIVEALKKDHGKELEKLR 612
            .:..::.|.|.:    ||..||....:|.|            ||:|
 Worm   521 SDYVSRAEYDAL----LDRFRALESRVLAI------------EKIR 550

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CD2APNP_036252.1 Interaction with ANLN and localization to the midbody. /evidence=ECO:0000269|PubMed:15800069 1..175 31/103 (30%)
SH3_CD2AP_1 3..58 CDD:212986
SH3_CD2AP_2 111..165 CDD:212987 21/58 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 168..209 8/47 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 227..256 7/33 (21%)
SH3_CD2AP_3 271..327 CDD:212989 27/58 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 333..428 27/100 (27%)
SH3-binding. /evidence=ECO:0000255 336..352 7/17 (41%)
SH3-binding. /evidence=ECO:0000255 378..397 9/22 (41%)
SH3-binding. /evidence=ECO:0000255 410..422 1/11 (9%)
cdap-2NP_491143.3 SH3 53..104 CDD:473055 20/51 (39%)
SH3 194..249 CDD:473055 25/54 (46%)
Blue background indicates that the domain is not in the aligned region.

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